The invention discloses N4-hydroxycytidine monohydrochloride, a
crystal form C and a preparation method thereof. The N4-hydroxycytidine monohydrochloride has the effect of preventing and treating infection of various viruses including new coronal pneumonia and is shown in a formula I. N-hydroxycytidine and
hydrochloric acid are subjected to a salt forming reaction, a
crystallization solvent is added after a
solvent is removed, and the N4-hydroxycytidine monohydrochloride is prepared through dissolving, crystallizing, filtering and
drying. The N4-hydroxycytidine monohydrochloride and the
crystal form C thereof have relatively good stability and
druggability, can form a pharmaceutical composition and a preparation thereof, and exert economic and
social benefits in prevention and treatment of novel
coronavirus infection; and the invention also discloses a pharmaceutical composition and application of the N4-hydroxycytidine monohydrochloride and the
crystal form C of the N4-hydroxycytidine monohydrochloride. The compound is used for preparing medicines for preventing or treating symptoms or diseases caused by respiratory syncytial
virus, influenza
virus,
chikungunya fever
virus,
Ebola virus, Venezuela
equine encephalitis virus, Eastern or western
equine encephalitis virus,
coronavirus or
Zika virus.