45results about How to "Achieve quality control" patented technology

The invention discloses an insulating sleeve packaging production line and a control and use method thereof.The insulating sleeve packaging production line comprises a feeding system, a detection system, a pipe cutting and pulling system, a conveying system, a waste collecting system and a bundling and packaging system, and insulating sleeves are conveyed to the detection system through the feeding system; qualified products are pulled and conveyed to the conveying system through the cutting and pipe pulling system, and packaging is completed through the bundling and packaging system; when the detection system detects defective products, single-single cutting is carried out in the pipe cutting and drawing system, and waste collection is completed through the waste collection system. According to the invention, the defects of the sleeve can be detected, the detection device detects the defective sleeve by using the sensor under the condition that a packaging line is not stopped, manual intervention is not needed, the sleeve is not damaged, the quality control of the sleeve is realized in an automatic manner, the detection precision is improved, and a large amount of manpower and material resources are saved.

The invention relates to the technical field of biomedical engineering, and discloses a hyperspectral microscope combined HE staining section identification method, which comprises a data acquisition module, a data analysis module, an abnormal data processing module, a data management module and a control module, the data analysis module calculates an automatic dyeing control index Q1, a microscope imaging stability coefficient S1 and an image quality evaluation score G1, and the abnormal data processing module identifies dyeing abnormal data in an automatic dyeing process and abnormal data in a microscope imaging process according to calculated numerical values and judges whether the final imaging quality reaches the standard or not; the data management module carries out data correction and fault diagnosis on dyeing abnormal data in the automatic dyeing process and abnormal data in the microscope imaging process according to the abnormal data automatically recognized by the abnormal data processing module and sends corrected parameters and fault diagnosis information to the control module at the same time, and the control module issues a repair instruction.

The invention relates to the technical field of cable production, and particularly discloses a cable insulation layer eccentricity calibration method, which comprises the following steps: S1, on a cable production line, multiple groups of optical sensors are uniformly arranged around a cable at certain angle intervals, and the optical sensors are used for measuring distance information of different positions on the surface of the cable; s2, acquiring data of the sensor in real time by using a high-speed data acquisition card, and transmitting the data to a computer for processing; and S3, constructing a three-dimensional shape model of the cable insulation layer by using the collected distance data through a triangulation method. According to the cable insulation layer eccentricity correction method, eccentricity calculation under different scales, including local eccentricity and overall eccentricity, is considered, the non-uniformity of the insulation layer can be better reflected, more comprehensive information is provided for quality control, and compared with the prior art, the cable insulation layer eccentricity correction method has the advantage that the calculation efficiency is improved. The system can accurately position a local problem area so as to adjust production parameters in a targeted manner, and can be used as an early warning system to timely discover potential problems.

The invention provides a construction detection device and a construction method of an anti-seepage wall, and belongs to the technical field of engineering construction equipment.The construction detection device comprises an annular guide rail which is fixed to a milling rack in the circumferential direction of the milling rack; the sliding block is connected to the annular guide rail in a sliding mode, the sliding block is configured to be driven by external force to move on the annular guide rail, and the sliding block is fixedly connected with a detection piece used for detecting a groove body; when the milling rack enters the groove body, the detection piece synchronously moves along with the sliding block in the circumferential direction of the milling rack so as to detect at least part of the groove body. According to the construction detection device provided by the invention, the annular guide rail is arranged on the milling rack, and the detection piece can synchronously move on the annular guide rail along with the sliding block to detect at least part of the groove body, so that the quality detection and control work of the groove body can be carried out in the construction process, and the groove body can be repaired and protected in time; and the grooving quality is ensured.

The invention discloses a steel skeleton reinforced nylon pipeline prefabricating and forming mechanism and a quality control method, and relates to the field of nylon pipelines, and the steel skeleton reinforced nylon pipeline prefabricating and forming mechanism comprises a pipeline pouring cavity used for pouring after nylon hot melting; the exterior of the steel skeleton fixing cylinder is covered with the formed net-shaped steel skeleton; the driving assembly is fixed to the inner wall of the steel framework fixing cylinder in an inserted mode and used for driving the steel framework fixing cylinder to move left and right, the driving assembly comprises a fixing plate fixed to the end of the pipeline pouring cavity, and a base is fixed to the fixing plate and the bottom of the pipeline pouring cavity; the replacing and adjusting assembly is located on one side of the driving assembly and used for replacing the steel framework fixing cylinders with different inner diameters, the replacing and adjusting assembly comprises a rotating seat, the rotating seat is fixed to the side face of the base, a plurality of placing plates are rotationally connected to the interior of the rotating seat, and the steel framework fixing cylinders with the different inner diameters are placed on the placing plates; the embedded depth of the steel skeleton net in the nylon pipeline can be conveniently controlled, and meanwhile the enhanced film thickness of the inner wall film of the pipeline can be controlled.

The invention discloses an auxiliary ground automatic station visibility quality control system based on multi-source data, and particularly relates to the technical field of ground automatic station visibility quality control, which comprises a multi-source data collection module, a ground automatic station meteorological anomaly judgment module, a multi-source data assimilation module and a quality control module, the meteorological data acquisition module is used for collecting various meteorological data from a plurality of different information sources in real time, the ground automatic station meteorological abnormity judgment module is mainly used for comprehensively checking and analyzing meteorological observation data of a ground automatic station so as to judge whether the weather is in a normal state or not, and early warning is given out in time when abnormity is found, and the multi-source data assimilation module is used for analyzing the meteorological data of the ground automatic station. By integrating meteorological data from different sources, the quality and accuracy of the meteorological data are improved, a quality control module effectively screens and corrects abnormal or suspicious meteorological data by executing space consistency check and background consistency check, and therefore high-quality meteorological information is provided.

The invention discloses an HPLC (High Performance Liquid Chromatography) detection method for impurities in a diphenhydramine hydrochloride bulk drug, which adopts a high performance liquid chromatography method for detection, and the chromatographic conditions are as follows: a chromatographic column takes octadecylsilane chemically bonded silica with the particle size of 4-5 [mu] m as a filler; the column length is 250 mm, and the column inner diameter is 3-4.6 mm; mobile phases: a mobile phase A is a mixture of a phosphate buffer solution and acetonitrile, and a mobile phase B is acetonitrile; performing gradient elution; the sample size is 10-20 [mu] l; the flow velocity is 1.0 to 1.4 ml / min; the detection wavelength is 210 to 230 nm; the column temperature is 28-32 DEG C; the detection method is easy to operate, high in sensitivity, good in specificity and high in accuracy, and the content of specific impurities (the impurity A, the impurity B, the impurity C, the impurity D, the impurity E, the impurity F and the impurity G) and non-specific impurities in diphenhydramine hydrochloride can be accurately controlled, so that the quality of diphenhydramine hydrochloride is effectively controlled, and quality control over the diphenhydramine hydrochloride raw material is achieved.

The invention discloses a method for determining the purity of tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate, which adopts a gas chromatographic method, adopts a capillary column which takes (5%-phenyl)-95% methylpolysiloxane copolymer as a stationary liquid as a gas chromatographic column, and adopts a temperature rising procedure to detect the purity of tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate. And after the sample introduction, calculating the purity of the tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate according to a peak area normalization method, so as to obtain the tert-butyl-(S)-[2-(2-cyano-4, 4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate. According to the method, the purity of Boc-Fapi-a is detected by adopting a gas chromatography temperature programming method, so that the influence of weak UV response signals and different response intensities of various impurity components can be avoided, the technical blank of lack of an effective chromatographic detection method for the substance at present is filled up, the convenient quality control is realized, and the detection requirement is met.

The application discloses a C-band tuning-free duplexer and belongs to the technical field of microwave filters. The tuning-free duplexer comprises an upper conductor and a lower conductor, and the upper conductor and the lower conductor are buckled one above the other to form a waveguide cavity. The upper conductor is provided with a combining port in the middle of the top, and the lower conductor is provided with a low-frequency input / output port and a high-frequency input / output port at the bottom. The waveguide cavity from the low-frequency input / output port to the combining port constitutes a low-end filter, and the waveguide cavity from the high-frequency input / output port to the combining port constitutes a high-end filter. The main bodies of the high-end filter and the low-end filter are both a plurality of waveguide resonant cavities arranged along a straight line, the middle positions of each waveguide resonant cavity are provided with cavity loading, and adjacent waveguide resonant cavities are connected through inter-cavity coupling. The tuning-free duplexer adopts a symmetrical structure and a center loading mode, realizes tuning-free assembly, has the characteristics of high power bearing capacity, low transmission loss and excellent signal isolation, and is suitable for a C-band communication system.

The invention discloses a high-strength bolt assembly for connecting box-type beams and columns, comprising: a box-type component, a top plate is provided on the top of the box-type component, and an outer cylinder is installed on the lower surface of the box-type component; an inner cylinder is installed on the bottom of the outer cylinder; two fixing members symmetrically installed on the inner wall of the outer cylinder, a limit plate is radially extended inward from the top of the fixing member, and the bottoms of the two fixing members are connected by a steel wire; a support rod, the bottom end of the support rod passes through the top surface of the inner cylinder and is connected to the center point of the steel wire, a spring is also wound on the support rod, and the bottom end of the spring is connected to the top surface of the inner cylinder; and a torsion shear type high-strength bolt, the screw head of the torsion shear type high-strength bolt is connected to the top of the support rod, the top of the spring is connected to the screw head of the torsion shear type high-strength bolt, and the screw head of the torsion shear type high-strength bolt is closely attached to the lower surfaces of the limit plates of the two fixing members. The invention utilizes the principle of lever to improve work efficiency and avoid the defective rate of finished products caused by traditional welding operations.

The invention discloses a microwave module intelligent detection platform and detection method.The microwave module intelligent detection platform comprises an overturning platform and a detection platform, the detection platform comprises visual detection equipment, a sliding guide rod, a visual base, a supporting rod and a rotating device, and the visual detection equipment is arranged on the sliding guide rod; the rotating device is used for shooting an image of the microwave module for visual inspection, is arranged on the supporting rod and below the visual inspection equipment, and can drive the overturning platform to rotate; the overturning platform is horizontally arranged on the supporting rod and below the visual inspection equipment and comprises an air cylinder, an elastic clamping head, a product stopping block, a product positioning block, a pushing air cylinder connector, a motor coupler and a servo motor, and the servo motor is used for enabling the rotating device to rotate through the motor coupler so as to drive the overturning platform to rotate; and overturning and double-sided detection of the microwave module are realized. The detection precision and efficiency of the microwave module can be remarkably improved, and quality control in the mass production process is achieved.

This invention provides a fingerprint spectrum of Yishen Wufa Oral Liquid, its construction method, and its application, as well as a multi-index component detection method for Yishen Wufa Oral Liquid, relating to the field of pharmaceutical analysis and structural technology. The fingerprint spectrum of Yishen Wufa Oral Liquid constructed by this invention includes 20 characteristic peaks, including ferulic acid, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside, astragaloside A, psoralen, isopsoralen, and emodin. The chromatographic peaks are abundant and attributed to the effective components of psoralen (roasted with black sesame seeds), angelica, poria cocos, wolfberry, fleeceflower root (processed with black bean wine), achyranthes bidentata, and astragalus complanatus. This provides a more comprehensive reflection of the overall chemical composition and quality of Yishen Wufa Oral Liquid, facilitating more effective guidance for feed addition and strict standardization of production operations. It also helps improve the safety and efficacy of Yishen Wufa Oral Liquid in clinical use, possessing high application value.

The embodiment of the invention discloses a positioning method for M estimation GNSS (Global Navigation Satellite System) quality control based on w inspection, which comprises the following steps of: 1, judging whether the requirement of w inspection is met or not, if so, entering a step 2, otherwise, entering a step 4; 2, w inspection is carried out, if w inspection is passed, the step 4 is carried out, and if w inspection is not passed, the step 3 is carried out; 3, judging whether the satellite numbers corresponding to the maximum inspection amount in the corresponding w inspection and the maximum inspection amount in the M estimation are the same or not, and finally, regarding the satellite corresponding to the optimal solution position as a new universal set calculation positioning solution based on the same and different satellite numbers; and 4, performing M estimation, and outputting a corresponding positioning solution. According to the method, the optimal resolving position of the user is obtained by removing the gross error through w inspection and reducing the weight of the gross error through M estimation, and then quality control over the satellite pseudo-range observation value in the urban environment is achieved, so that it is guaranteed that the user obtains reliable positioning quality.

The invention discloses a method for determining the purity of tert-butyl-(S)-[2-(2-cyano-4,4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate, which comprises a capillary column with (5%-phenyl)-95% methyl polysiloxane copolymer as a stationary liquid as a gas chromatography column, and a temperature program is used to calculate the purity of tert-butyl-(S)-[2-(2-cyano-4,4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate by a peak area normalization method after injection. The invention adopts a gas chromatography program temperature method to detect the purity of Boc-Fapi-a, which can avoid the influence of weak UV response signals and different response intensities of each impurity component, makes up for the technical gap of the current lack of an effective chromatographic detection method for the substance, realizes convenient quality control, and meets the detection requirements.

The invention discloses an olfactory function fMRI real-time nerve feedback brain region activation monitoring system and method, which can monitor the activation intensity of an olfactory brain region in real time, realize quality control of the olfactory task state fMRI olfactory brain region activation intensity, ensure that olfactory function imaging examination is accurate and reliable, realize individualized olfactory activated brain region positioning and improve the olfactory function imaging examination accuracy. According to the method, accurate target brain region information can be provided for a testee, the testee and an experimenter are guided to collect effective olfactory task state fMRI data, and the method is of great significance to research of olfactory related cognitive neurodegenerative diseases. The system comprises a scale and olfactory behavior data acquisition module, an individualized primary olfactory cortex target module, a dynamic multi-stage olfactory fMRI module, a real-time olfactory activation target region activation intensity monitoring module and an olfactory task state fMRI effect evaluation module.

This invention discloses a method for evaluating the quality of honeysuckle dew based on gas chromatographic characteristic spectroscopy, belonging to the field of pharmaceutical quality analysis. Through comparative analysis of a large number of samples, five volatile characteristic components in the GC chromatogram of honeysuckle dew were identified: n-hexanol, phytol, linalool, furfural, and α-terpineol. Based on this, a GC characteristic chromatogram of honeysuckle dew was established. This invention also identified two characteristic components with a strong positive correlation in content. By utilizing the GC characteristic chromatogram and the peak area ratio of the two positively correlated characteristic components, accurate detection of the quality of honeysuckle dew was finally achieved.

The invention discloses a method for detecting optical isomers of tert-butyl-(S)-[2-(2-cyano-4,4-difluoropyrrolidine-1-yl)-2-oxyethyl] carbamate, and adopts a high-performance liquid chromatography determination method. The determination method comprises the following steps: using a chromatographic column with amylose-tris(3,5-diphenylcarbamate) as a filler, using n-hexane-ethanol-trifluoroacetic acid with a volume ratio of 700-750:250-300:1 as a mobile phase, preparing a solution for injection, and calculating the optical isomer content by a peak area normalization method. The invention makes up for the current technical gap of lacking high-performance liquid chromatography detection of the substance.

The present invention discloses a visibility quality control system for a ground automatic station assisted by multi-source data, and specifically relates to the technical field of visibility quality control for ground automatic stations, including: a multi-source data collection module, a ground automatic station meteorological anomaly judgment module, a multi-source data assimilation module and a quality control module, wherein the multi-source data collection module is used to collect various meteorological data from multiple different information sources in real time, the ground automatic station meteorological anomaly judgment module is mainly used to comprehensively check and analyze the meteorological observation data of the ground automatic station to judge whether the meteorology is in a normal state, and to issue an early warning in time when anomalies are found, the multi-source data assimilation module improves the quality and accuracy of meteorological data by integrating meteorological data from different sources, and the quality control module effectively screens and corrects abnormal or suspicious meteorological data by performing spatial consistency checks and background consistency checks, thereby providing high-quality meteorological information.

The invention discloses an analysis method of veratraldehyde related substances. The method comprises the following steps: 1, solution preparation: respectively preparing a diluent, a test solution, a contrast solution, a mobile phase A and a mobile phase B; and 2, high performance liquid chromatography determination: respectively and precisely measuring the test solution and the contrast solution, injecting the test solution and the contrast solution into a high performance liquid chromatograph for detection, recording a chromatogram, and calculating the content of the veratraldehyde related substances. The analysis method for the veratraldehyde related substances is free of blank solvent interference, good in specificity, high in sensitivity and accuracy and capable of detecting one or more of 10 impurities in veratraldehyde at a time, so that the impurities of a sample can be measured more comprehensively, quality control over veratraldehyde is achieved, and the analysis method has good application prospects.

The invention relates to the technical field of chemical analysis, and particularly discloses a method for detecting isopropyl acetoacetate related substances. According to the method, Astec CHIRRADEX B-DM (0.25 mm * 30m * 0.12 [mu] m) is adopted as a detection chromatographic column, the column temperature is set to be 38-42 DEG C and maintained for 4-6 min, then the temperature is increased to 175-185 DEG C at the rate of 4-6 DEG C / min and maintained for 1-3 min, the temperature of a sample inlet is 115-125 DEG C, the temperature of a detector is 245-255 DEG C, and the split ratio is (5-10): 1, so that simultaneous quantitative detection of multiple impurities in isopropyl acetoacetate is realized. The method provided by the invention is more beneficial to truly reflecting the quality of isopropyl acetoacetate, is beneficial to monitoring the synthesis process of isopropyl acetoacetate, is further beneficial to improving the quality of dipine drugs and reducing the drug use risk, and has a relatively high practical value.

The invention relates to the technical field of cell exosome preparation, in particular to an optimization method and system for preparation of ovarian granular cell exosomes based on iPSC (induced pluripotent stem cells). Basic culture parameters are determined based on the human pluripotent stem cells, the optimal induction factors and the optimal concentration, directional culture is conducted on the human pluripotent stem cells through the basic culture parameters, a differentiated cell population is obtained, marker detection is conducted on the differentiated cell population, and the anti-mullerian hormone positive rate and the second gene positive rate are obtained. Performing multiplication culture on the target ovarian granular cells to obtain a cell culture supernatant, and separating the cell culture supernatant by utilizing the optimal separation parameters to obtain an exosome extract, thereby completing the optimization of exosome preparation. The intelligent degree of the exosome preparation process can be improved.

The application relates to the field of biochemical technology, and particularly discloses a method for efficiently extracting green mung bean starch. The method comprises the following steps: obtaining green bean sprouts by ultrasonic-assisted soaking and germination culture of green mung beans; obtaining green bean sprout powder by drying, crushing and sieving the green bean sprouts; mixing the green bean sprout powder with a NaOH solution, oscillating, washing, centrifuging, filtering and obtaining pure starch, and finally drying, grinding and sieving to obtain germinated green mung bean starch. The extraction method combines ultrasonic pretreatment with a germination process, effectively improves the gelatinization characteristics of the starch, significantly improves the starch viscosity, thereby enhancing the applicability of the starch in food processing, and meanwhile, the nutritional and functional characteristics of the green mung bean starch are retained.

The present invention provides a separation method and a detection method for components in a bilastine sample, and relates to the technical field of drug quality analysis. The present invention adopts HPLC chromatography, uses phosphate buffer solution and methanol-acetonitrile as a mobile phase system, adopts a specific mobile phase system and a gradient elution program, and adds ion pair reagents-triethylamine and / or n-octylamine in the phosphate buffer, which can highly separate bilastine, process impurities (impurity A, impurity B, impurity C and impurity D), degradation impurities (impurity E, impurity F), and antibacterial agents (methyl parahydroxybenzoate and propyl parahydroxybenzoate) at one time, with short time consumption, high separation efficiency, simple operation, and low separation cost. The present invention uses a detector or a mass spectrometer to detect the separation results, and the detection results of the components in the bilastine sample can be obtained. The detection method provided by the present invention is efficient and convenient, has good reproducibility, strong specificity, high accuracy, and high sensitivity.

The invention relates to the technical field of traditional Chinese medicine, in particular to a preparation method of a roxburgh rose leaf extract, a construction method of a specific chromatogram and a detection method of brachyphyllinic acid and ellagic acid in the roxburgh rose leaf extract.The preparation method comprises the steps that roxburgh rose leaf decoction pieces are decocted twice to obtain decoction liquid, and the decoction liquid is filtered; the roxburgh rose leaf extract is prepared from roxburgh rose leaf decoction pieces, through an accelerated stability test, the content and the moisture content are relatively stable, and specific chromatograms and a content detection method are good in specificity, repeatability and stability.

This invention provides a honeysuckle and codonopsis composition. The composition, which includes the determination of the main components of codonopsis, scientifically combines honeysuckle (containing iridoids and phenolic acids) with codonopsis (containing alkynes, polysaccharides, and newly discovered compounds) to form a synergistic compound system. An integrated quality control method of "multi-index content determination - dual-wavelength characteristic spectroscopy" ensures stable quality. The invention elucidates that this composition exerts its anti-inflammatory and antioxidant effects through a multi-pathway synergistic mechanism: the honeysuckle component targets and inhibits inflammatory signaling pathways such as NF-κB and MAPK, while the codonopsis component achieves systemic protection by regulating intestinal flora, enhancing the mucosal barrier, and modulating immunity. This composition is suitable for the prevention and treatment of inflammatory diseases such as enteritis and chemotherapy-induced intestinal injury, reflecting a deep integration of the traditional Chinese medicine principle of "clearing heat and strengthening the body, treating both the root cause and symptoms" with modern pharmacological mechanisms.

The invention provides a synthetic method of Pulsatilloside A. The Pulsatilloside A is prepared by taking pulsatilla saponin B4 as a starting raw material. The invention further provides a detection method of the pulsatabiloside A. The invention further provides a detection method of the pulsatabiloside A. According to the invention, pulsatiloside A is synthesized by taking pulsatilla saponin B4 as a raw material, and the pulsatilla saponin B4 is one of the main components of the traditional Chinese medicine pulsatilla, and is rich and reliable in source. The pulsatilla saponin B4 is subjected to structural modification, separation and purification, the steps are simple and reliable, and the compound Pulsatiloside A which is rare in nature can be obtained. The invention provides the detection method of the Pulsatiloside A, the detection method is stable, and the quality control of the Pulsatiloside A can be realized; meanwhile, the pulsatilla saponin A3 and 23-hydroxybetulinic acid can be detected, and the quality control on the three components can be realized at the same time.

The application relates to the technical field of heat-insulating metal plates, and particularly discloses a rare earth reflective heat-insulating metal plate and a roll coating quality detection method thereof. The rare earth reflective heat-insulating metal plate is a metal plate with high reflective capacity for sunlight and infrared rays and heat-insulating function. The surface coating of the metal plate is composed of a multilayer overlapping structure of a rare earth composite reflective material coating and a rare earth composite hollow microsphere heat-insulating material coating. In the preparation process of the rare earth reflective heat-insulating metal plate, machine vision is used to construct a roll coating quality detection scheme. The scheme can automatically identify defects on the surface of the coating, such as bubbles, cracks and unevenness, and realize mass roll coating quality control, so as to guarantee the heat-insulating performance and durability of the final product.

The invention relates to the technical field of heat insulation metal plates, and particularly discloses a rare earth reflection heat insulation metal plate and a roller coating quality detection method of the rare earth reflection heat insulation metal plate. The surface coating is composed of a multi-layer overlapping structure of a rare earth composite reflecting material coating and a rare earth composite hollow microbead thermal insulation material coating. In the preparation process of the rare earth reflective heat insulation metal plate, machine vision is used for constructing a roller coating quality detection scheme, defects such as bubbles, cracks and non-uniformity on the surface of a coating can be automatically recognized, large-scale roller coating quality control is achieved, and therefore the heat insulation performance and durability of a final product are guaranteed.

The present invention belongs to the technical field of drug analysis, and in particular to a HPLC detection method for a norepinephrine bitartrate intermediate NEL‑SIP‑02 and its related impurities. The detection method is: using octadecylsilane chemically bonded porous silica gel embedded in a carbamate group in a ligand as a reverse phase chromatographic column of a filler, with a weak elution mobile phase: strong elution mobile phase = (95-35): (5-65), v / v, gradient elution, the weak elution mobile phase is 10mM potassium dihydrogen phosphate and 100mM sodium perchlorate, pH 2.1; the strong elution mobile phase is methanol: acetonitrile volume ratio is 20: 80; its chromatographic conditions: mobile phase flow rate is 0.8-1.2ml / min; the chromatographic column temperature is 25-35°C; the detection wavelength is 200-230nm. The detection method is simple to operate and low in cost. It can effectively separate the intermediate NEL-SIP-02 and its related impurities. The peak shape of the main peak is symmetrical, which can better achieve the quality control of the intermediate NEL-SIP-02 and the raw material norepinephrine bitartrate, improve the quality of the final product, and ensure its safety and effectiveness in clinical use.

The invention relates to the technical field of chemical medicine quality detection methods, in particular to a reversed-phase high-performance liquid chromatography method for quantitative analysis of impurities C, D and E of atomoxetine hydrochloride oral solution by single-marker multi-components. According to the determination method, a solid core particle chromatographic column bonded with a diphenyl stationary phase is adopted, a sodium octanesulfonate solution-methanol (88-92: 8-12) is taken as a mobile phase A, methanol is taken as a mobile phase B, and a gradient elution procedure is adopted for detection. The detection wavelength is 205-225 nm, the column temperature is 25-30 DEG C, and the flow velocity is 0.9-1.1 ml / min. The method is good in specificity, precision, repeatability and solution stability and strong in durability, and can solve the technical problem that various impurities with similar structures in atomoxetine hydrochloride are difficult to effectively separate and detect in the prior art. The method can be used for controlling the quality of the atomoxetine hydrochloride oral solution, improving the quality control level and ensuring the product quality, and has an ideal application prospect.