Application of gallic acid and derivatives and structural analogs thereof in preparation of anti-coronavirus medicines
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGZHOU SHENGPU INVESTMENT MANAGEMENT
- Publication Date
- 2021-02-09
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to the application of gallic acid and its derivatives and structural analogs in the preparation of anti-coronavirus drugs. Background technique
[0002] In terms of systematic classification, coronaviruses belong to the order Nidovirales, the family Coronaviridae, and the genus Coronavirus. Among them, the viruses of the coronavirus genus are RNA viruses with an envelope and a linear single-stranded positive strand genome, and are a large class of viruses that exist widely in nature. The diameter of coronavirus is about 80-120nm, the 5′ end of the genome has a methylated cap structure, and the 3′ end has a poly(A) tail. The total length of the genome is about 27-32kb. . Coronaviruses only infect vertebrates, including humans. Currently, coronaviruses known to infect humans and cause severe outbreaks include SARS-CoV, SARS-CoV-2, MERS-CoV, HCoV-229E, HCoV-NL63,...