Traditional Chinese medicine granules for treating chronic hepatitis and forepart hepetocirrhosis and preparation method thereof

A technology of chronic hepatitis and granules, applied in the field of traditional Chinese medicine for the treatment of chronic hepatitis and early cirrhosis, can solve the problems of removing hepatitis B virus, increasing the mutation rate of hepatitis B virus, increasing the severity of the disease, and reducing inflammation and necrosis of liver cells. , regulate the immune function of the body, reduce the effect of liver cell degeneration

Active Publication Date: 2013-05-29
THE FIFTH HOSPITAL OF SHIJIAZHUANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many clinical treatment methods for chronic hepatitis and early liver cirrhosis. Although some western medicines and chemical medicines can play a certain therapeutic effect to a certain extent, they have obvious toxic and side effects, and long-term use of large amounts can lead to leukopenia
For example, the commonly used western medicine lamivudine can only relieve hepatitis B virus, but cannot really remove hepatitis B virus, and ca...

Method used

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  • Traditional Chinese medicine granules for treating chronic hepatitis and forepart hepetocirrhosis and preparation method thereof
  • Traditional Chinese medicine granules for treating chronic hepatitis and forepart hepetocirrhosis and preparation method thereof
  • Traditional Chinese medicine granules for treating chronic hepatitis and forepart hepetocirrhosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Granules for treating chronic hepatitis and early liver cirrhosis, the raw materials are composed of the following substances in parts by mass:

[0051] Astragalus 160g, Codonopsis 160g, Atractylodes macrocephala 170g, Tianhuafen 150g, Anemarrhena 240g, Sanleng 160g, Curcuma 150g, Gallinarum 170g, Paeoniae Alba 240g, Poria 250g, Angelica 240g, Salvia miltiorrhiza 480g, leeches 96g.

[0052] The preparation method comprises the following steps:

[0053] (1) Take the medicinal material according to the formula, put it in a multi-functional reflux extraction tank, and reflux extraction twice, add 10 times the amount of water for the first time, decoct for 1.5 hours, add 8 times the amount of water for the second time, decoct for 1 hours, combined two decoctions;

[0054] (2) Concentrate in a vacuum concentrator until the relative density is 1.08-1.25, the temperature during vacuum concentration is below 60°C, and the vacuum degree is 0.08MPa;

[0055] (3) In the concentr...

Embodiment 2

[0057] Granules for treating chronic hepatitis and early liver cirrhosis, the raw materials are composed of the following substances in parts by mass:

[0058] Astragalus 140g, Codonopsis 180g, Atractylodes macrocephala 14g, Tianhuafen 180g, Anemarrhena 260g, Sanleng 150g, Curcuma 170g, Gallinarum 140g, Paeoniae Alba 200g, Poria 260g, Angelica 250g, Salvia miltiorrhiza 470g, leeches 90g.

[0059] The preparation method comprises the following steps:

[0060] (1) Weigh the medicinal materials according to the formula, put them in a multifunctional reflux extraction tank, and reflux extraction twice, add 8 times the amount of water for the first time, decoct for 1 hour, add 7 times the amount of water for the second time, decoct for 1.5 hours, combined two decoctions;

[0061] (2) Concentrate in a vacuum concentrator until the relative density is 1.08-1.25, the temperature during vacuum concentration is below 60°C, and the vacuum degree is 0.08MPa;

[0062] (3) In the concentr...

Embodiment 3

[0064] Granules for treating chronic hepatitis and early liver cirrhosis, the raw materials are composed of the following substances in parts by mass:

[0065] Astragalus 180g, Codonopsis 150g, Atractylodes macrocephala 180g, Tianhuafen 160g, Anemarrhena 220g, Sanleng 170g, Curcuma 190g, Gallinarum 150g, Paeoniae Alba 250g, Poria cocos 220g, Angelica 220g, Salvia miltiorrhiza 490g, leeches 110g.

[0066] The preparation method comprises the following steps:

[0067] (1) Take the medicinal material according to the formula, put it in a multi-functional reflux extraction tank, and reflux extraction 2 times, add 9 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 2 hours hours, combined two decoctions;

[0068] (2) Concentrate in a vacuum concentrator until the relative density is 1.08-1.25, the temperature during vacuum concentration is below 60°C, and the vacuum degree is 0.08MPa;

[0069] (3) In ...

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PUM

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Abstract

The invention discloses granules for treating chronic hepatitis and forepart hepetocirrhosis. The granules are prepared from the following substances in parts by weight of 14-18 parts astragalus mongholicus, 15-18 parts of codonopsis pilosula, 14-18 parts of white atractylodes rhizome, 15-18 parts of radices trichosanthis, 22-26 parts of rhizoma anemarrhenae, 15-17 parts of rhizoma sparganii, 15-18 parts of curcuma zedoary, 14-17 parts of endothelium corneum gigeriae galli, 20-25 parts of radix paeoniae alba, 22-26 parts of tuckahoe, 22-25 parts of angelica sinensis, 47-49 parts of root of red-rooted salvia, and 9-11 parts of leech. The granules disclosed by the invention can protect hepatocyte, reduces degeneration, necrosis and immune injury of the hepatocyte, promotes degradation of a collagenous fiber, adjusts cellular immune function, and reduces inflammation and necrosis of the hepatocyte. The traditional Chinese medicine granules are wide in the crowd in clinical use, long in application time, good in clinical curative effect and free of bad reaction.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine for treating chronic hepatitis and early liver cirrhosis. Background technique [0002] Chronic hepatitis refers to a chronic inflammatory disease of the liver caused by various reasons with a course of more than half a year. Most of them are transformed from acute viral hepatitis. Due to the disorder of the body's own immune function, long-term use of drugs that damage the liver and the body's allergy to drugs, alcoholism, lack of certain enzymes, and metabolic disorders can all lead to the occurrence of this disease. The clinical manifestations of traditional Chinese medicine are qi deficiency and blood stasis, distending pain in the flank, discomfort, lack of food, and fatigue. The incidence of chronic hepatitis has risen sharply. Statistics show that about 20% of patients with chronic hepatitis turn into liver cirrhosis,...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/16A61P1/16A61K35/62A61K35/37A61K35/57
Inventor 戴二黑邵石祥吴宗耀叶立红杨莉郑欢伟胡玮佳牛李义
Owner THE FIFTH HOSPITAL OF SHIJIAZHUANG
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