Method for preparing high-strength collagen tissue repair material product

Abstract

The invention relates to a method for preparing a high-strength collagen tissue repair material product. The method obtains the final collagen product through the treatment steps of salting out, centrifugation, dehydration, crosslinking and drying of a collagen solution. Because the treatment method adopts the mode of improving the solid content of collagen in collagen gel and the crosslinking density in the collagen gel, the mechanical property of the final product is greatly improved. Simultaneously, because the adopted method does not influence the biological property of the collagen, the final collagen product still maintains good biological activity. The collagen product can be used for the repair treatment of articular cartilage, meniscus and skin, the construction of artificial blood vessels and nerve conduits, and the like.

Description

technical field

[0001] The invention relates to a tissue repair substitute material, in particular to a preparation method of a high-strength collagen tissue repair material product. Background technique

[0002] With the development of modern society, there are more and more tissue damage problems caused by various reasons. Such as skin injuries caused by burns, scalds, knife wounds, firearm injuries, etc., limb blood vessel and nerve injuries caused by traffic accidents, loss of surrounding tissues caused by tumor resection, and articular cartilage and meniscus damage caused by sports injuries and pathological injuries. damage etc. There are various reasons for the injury, and the final result is the damage of connective tissues such as articular cartilage, meniscus, skin, blood vessels and nerves. Small-area, small-scale, low-injury tissue damage can be repaired automatically by the human body through the mobilization of autologous tissues and cells. Regenerative docki...