Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Regulation and control method of mechanical strength of natural biologic material products

A biomaterial and mechanical strength technology, applied in medical science, prosthesis, etc., can solve the problems of limiting the use of biomaterials, achieve the effect of increasing density, enhancing cross-linking density, and maintaining biological activity

Inactive Publication Date: 2010-02-17
SOUTH CHINA UNIV OF TECH
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can only be used for some unstressed biomaterials in clinical practice, which limits the use of these biomaterials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] After the collagen solution with a selected concentration of 6 g / L was freeze-dried, it was compressed to 50% of its original volume, and was cross-linked with a carbodiimide solution with a mass concentration of 1% at 10 degrees for 20 hours, and then freeze-dried for 24 hours to obtain a collagen solution with a certain concentration. Restorative material products with appearance characteristics. The article has a compressive strength of about 3000Pa.

Embodiment 2

[0025] After the collagen solution with a selected concentration of 12 g / L was lyophilized, it was compressed to 20% of its original volume, and was cross-linked with a carbodiimide solution with a mass concentration of 1% at 5 degrees for 24 hours, and then lyophilized for 24 hours to obtain a collagen solution with a certain concentration. Restorative material products with appearance characteristics. The article has a compressive strength of about 8000Pa.

Embodiment 3

[0027] After the collagen solution with a selected concentration of 12 g / L was freeze-dried, it was compressed to 5% of its original volume, and was cross-linked with a carbodiimide solution with a mass concentration of 1% at 20 degrees for 10 hours, and then freeze-dried for 24 hours to obtain a collagen solution with a certain concentration. Restorative material products with appearance characteristics. The article has a compressive strength of about 1.5 MPa.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Compressive strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a regulation and control method of mechanical strength of natural biologic material products. A final product is obtained by the treating steps of freezing and drying, compression, crosslinking and secondary drying on natural biologic material solution. The treating method adopts the controllable compression step for a primary product after freezing and drying, thereby controlling the density of a porous material product, reducing the porosity of the porous material product and controlling the mechanical performance of the final product by the step. Meanwhile, the adopted method does not influence the biologic performance of the initial natural biologic material, thereby still keeping better biologic activity of the final product.

Description

technical field [0001] The invention relates to a tissue repair substitute material, in particular to a method for regulating the mechanical properties of high natural polymer porous material products. Background technique [0002] With the development of modern society, there are more and more tissue damage problems caused by various reasons. Such as skin injuries caused by burns, scalds, knife wounds, firearm injuries, etc., limb blood vessel and nerve injuries caused by traffic accidents, loss of surrounding tissues caused by tumor resection, and articular cartilage and meniscus damage caused by sports injuries and pathological injuries. damage etc. There are various reasons for the injury, and the final result is the damage of connective tissues such as articular cartilage, meniscus, skin, blood vessels and nerves. Small-area, small-scale, low-injury tissue damage can be repaired automatically by the human body through the mobilization of autologous tissues and cells. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/14A61L27/56A61L27/26A61L27/24A61L27/22A61L27/20
Inventor 王迎军吴刚
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com