Regulation and control method of mechanical strength of natural biologic material products

A biomaterial and mechanical strength technology, applied in medical science, prosthesis, etc., can solve the problems of limiting the use of biomaterials, achieve the effect of increasing density, enhancing cross-linking density, and maintaining biological activity

Inactive Publication Date: 2010-02-17
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can only be used for some unstressed biomaterials in cl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1

[0023] The selected collagen solution with a concentration of 6 g / L is freeze-dried, compressed to 50% of the original volume, cross-linked with a carbodiimide solution with a mass concentration of 1% at 10 degrees for 20 hours, and then freeze-dried for 24 hours to obtain a certain Repair material products with appearance characteristics. The compressive strength of the product is about 3000Pa.

Example Embodiment

[0024] Example 2

[0025] The selected collagen solution with a concentration of 12 g / L was freeze-dried, compressed to 20% of the original volume, cross-linked with a carbodiimide solution with a mass concentration of 1% at 5 degrees for 24 hours, and then freeze-dried for 24 hours to obtain a certain Repair material products with appearance characteristics. The compressive strength of the product is about 8000Pa.

Example Embodiment

[0026] Example 3

[0027] The selected collagen solution with a concentration of 12 g / L is freeze-dried, compressed to 5% of the original volume, cross-linked with a carbodiimide solution with a mass concentration of 1% at 20 degrees for 10 hours, and then freeze-dried for 24 hours to obtain a certain Repair material products with appearance characteristics. The compressive strength of the product is about 1.5MPa.

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Abstract

The invention discloses a regulation and control method of mechanical strength of natural biologic material products. A final product is obtained by the treating steps of freezing and drying, compression, crosslinking and secondary drying on natural biologic material solution. The treating method adopts the controllable compression step for a primary product after freezing and drying, thereby controlling the density of a porous material product, reducing the porosity of the porous material product and controlling the mechanical performance of the final product by the step. Meanwhile, the adopted method does not influence the biologic performance of the initial natural biologic material, thereby still keeping better biologic activity of the final product.

Description

technical field [0001] The invention relates to a tissue repair substitute material, in particular to a method for regulating the mechanical properties of high natural polymer porous material products. Background technique [0002] With the development of modern society, there are more and more tissue damage problems caused by various reasons. Such as skin injuries caused by burns, scalds, knife wounds, firearm injuries, etc., limb blood vessel and nerve injuries caused by traffic accidents, loss of surrounding tissues caused by tumor resection, and articular cartilage and meniscus damage caused by sports injuries and pathological injuries. damage etc. There are various reasons for the injury, and the final result is the damage of connective tissues such as articular cartilage, meniscus, skin, blood vessels and nerves. Small-area, small-scale, low-injury tissue damage can be repaired automatically by the human body through the mobilization of autologous tissues and cells. ...

Claims

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Application Information

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IPC IPC(8): A61L27/14A61L27/56A61L27/26A61L27/24A61L27/22A61L27/20
Inventor 王迎军吴刚
Owner SOUTH CHINA UNIV OF TECH
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