Japanese schistosomiasis vaccine combined immunizing method and application of Japanese schistosomiasis vaccine

Abstract

The invention provides a Japanese schistosomiasis vaccine combined immunizing method and an application of the Japanese schistosomiasis vaccine, and belongs to the field of schistosomiasis prevention and treatment. According to the immunizing scheme, recombinant adenovirus vaccine (rAdV-SjTPI.opt) of optimized schistosoma japonicum triosephosphate isomerase (SjTPI.opt) is subjected to primary immunizations in an intramuscular way, and is subjected to reinforced immunization by recombinant protein vaccine (rSjTPI) in a hypodermatic way, and the immunization interval is 2 weeks. The immunization scheme has the effect of preventing Japanese schistosomiasis infection, is capable of inducing a host to generate body fluid with high level and cell immunity response after an animal is immunized, and the protecting force can be 70 percent. Furthermore, in the scheme, the two vaccines are simple to prepare, the immunization operation is convenient, and the vaccines have an excellent application prospect.

Description

technical field [0001] The invention relates to the field of prevention and treatment of schistosomiasis, in particular to a combined immunization method and application of schistosomiasis japonicum vaccine. Background technique [0002] Schistosomiasis is a serious neglected tropical disease. As of 2011, schistosomiasis is still prevalent in 78 countries and regions around the world, with a population of 243 million infected, and about 779 million people are threatened by the disease. The schistosomes that infect the human body mainly include Schistosoma haematobium, Schistosoma mansoni, Schistosoma intercalatum, Schistosoma japonicum and Schistosoma mekong, and my country is the most serious country for Schistosoma japonicum. After years of active and effective scientific prevention and control, the endemic areas of schistosomiasis have been compressed into Hunan, Hubei, Jiangxi, Anhui, Jiangsu in the lake area, and Yunnan and Sichuan in the mountainous areas. — Oncomelan...

AI Technical Summary

Problems solved by technology

In the research of schistosomiasis vaccine, there are only reports on combined immunization of DNA vaccine and protein vaccine, combined immunization of o

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