1 results about "DIAGNOSTIC ANTIGENS" patented technology

This invention discloses a fusion protein, PEDV RBD nanoparticle antigen, its preparation method, and its applications. The fusion protein is obtained by fusing the receptor-binding domain of the porcine epidemic diarrhea virus (PEDV) Spike protein to the N-terminus of a ferritin monomer via a linker peptide. It can self-assemble into PEDV RBD nanoparticle antigens with an average diameter of approximately 15 nm. The nanoparticle antigens exhibit structural integrity, enabling high-density multivalent display of the RBD, and possess excellent antigenic activity, specificity, thermal stability, and biocompatibility, making them suitable for large-scale production. This invention provides a safe, infection-free, and easily industrialized vaccine strategy for addressing PEDV infection. It can be further expanded for applications in veterinary vaccine formulation optimization and the research and development of diagnostic antigens and reagents, demonstrating good practicality and industrialization prospects.