6results about How to "Break through the bottleneck" patented technology

This invention discloses a portable low-temperature plasma device based on a Laval nozzle structure and its application, belonging to the field of plasma technology application technology. Specifically, it includes (1) the construction of the device; and (2) the use of the device for fungal eradication treatment and transdermal drug delivery enhancement treatment. The beneficial effects achieved by this invention are as follows: This invention is the first to apply the Laval nozzle structure to a portable low-temperature plasma device. The results show that the device can effectively improve the plasma jet performance and active particle content, significantly improve the treatment effect of fungal infections of the skin and nails and the transdermal drug penetration efficiency, while solving the problems of large size, reliance on external power supply, and complex operation of traditional plasma devices. Therefore, using this invention for the treatment of fungal infections of the skin and nails and for enhanced transdermal drug delivery has advantages such as ease of operation, high safety, non-invasiveness, and high efficiency, and thus has potential application prospects in the field of skin disease treatment and transdermal drug delivery.

An event camera image reconstruction method based on an optical flow-guided multi-frame fusion network belongs to the field of computer vision and image processing technology. Step 1: Acquire event data and convert it into continuous, smooth spatiotemporal voxels using a Gaussian distribution-based full-time-interval voxel encoding scheme. Step 2: Construct an optical flow-guided FMF-Net network. Step 3: Design a comprehensive loss function for training the FMF-Net network. Step 4: Supervised training of the FMF-Net network using a publicly available event dataset. Step 5: Utilize the trained FMF-Net network, input spatiotemporal voxels, and output a high-fidelity reconstructed image. This invention fully utilizes long-term motion cues and temporal dynamic features to achieve high-fidelity image reconstruction under high-speed motion and sparse event input, solving the problems of detail loss and poor consistency in reconstruction under dynamic scenes in existing methods, and significantly improving the structural similarity and visual quality of the reconstructed image.

The present application relates to a kind of fusion protein comprising selenomethionine and its application in the treatment of acute pancreatitis, belong to the field of biological medicine.The fusion protein is prepared by in vivo biological chelation method from TAT-14-PTD-p65 fusion protein and organic selenium (selected from selenomethionine), the fusion protein is designed by "Nrf2 activation-NF-κB inhibition-selenium donor" trinity, comprising Nrf2 activation element (TAT-14 peptide), NF-κB inhibition element (PTD-p65-P1) and selenium donor element (selenomethionine), is connected by (Gly4Ser) 2 connecting peptide to avoid spatial interference.Experiments show that the fusion protein and its selenium chelate can inhibit the activation of pancreatic tissue NF-κB inflammatory pathway, up-regulate pancreatic Nrf2 / HO-1 antioxidant pathway, significantly reduce the serum lipase and amylase levels of C57 mice with acute pancreatitis, inhibit inflammatory response and oxidative stress, relieve pancreatic tissue damage, and selenium chelate is better.

The present application relates to the field of text processing, in particular to a text generation method based on a large model, an electronic device and a storage medium. The method first acquires an event topic input by a user or composite information containing reference text, retrieves associated text from a text library based on the event topic; when the input only contains the event topic, the associated text is directly used as the model guidance text; if the reference text is contained, the associated text and the reference text are integrated as the guidance text, and three types of feature values representing the text scale, the number of entities and the number of entity relationships are extracted; the extracted feature values are compared with the preset scale threshold, entity quantity threshold and entity relationship threshold, and the text generation mode is dynamically selected accordingly. The present application can realize intelligent regulation and control of the processing load of the large model, ensure the integrity of the generated text semantics, and avoid the efficiency decline caused by the input scale exceeding the processing capacity of the model.

The invention discloses an engineering information representation method, and relates to the technical field of engineering drawing, and the method comprises the steps: representing each engineering object in a target plane engineering drawing by employing a keyword in an engineering information keyword library, and obtaining the digital information of the target plane engineering drawing; the engineering information keyword library comprises keywords of various engineering objects, and the keywords of each engineering object comprise serial numbers, external dimension parameters, internal dimension parameters and position parameters; each engineering object has a unique number, the internal size parameter is internal structure size information of the engineering object, and the position parameter comprises at least one piece of position information of the engineering object; and storing the digitized information of the target plane engineering drawing. The method can improve the expression efficiency of the engineering information.

The invention relates to the technical field of biological medicines, and discloses a bacterial membrane vesicle entrapped with calcium phosphate nanoparticles and a preparation method of the bacterial membrane vesicle. The preparation method comprises the following steps: step 1, preparing calcium phosphate nanoparticles CaP; step 2, preparing bacterial membrane vesicles (BMVs); and step 3, encapsulating CaP by using the BMVs, respectively dissolving the BMVs and the CaP nano-particles in a buffer solution, mixing the BMVs and the CaP nano-particles into a solution according to a mass ratio, and carrying out ultrasonic treatment and centrifugation to obtain a CaP-encapsulated BMVs suspension. According to the bacterial membrane vesicle entrapped with the calcium phosphate nanoparticles and the preparation method of the bacterial membrane vesicle, efficient entrapment of CaP particles in BMVs is achieved; the biocompatibility and the biological safety of the BMVs are improved through CaP modification, and a core foundation is laid for clinical transformation of the BMVs; the prevention performance of the BMVs entrapped with the CaP is improved, the bottleneck of a BMVs natural membrane carrier in infection prevention is broken through, and a wide prospect is opened up for the field of bacterial infection prevention.