Multi-epitope fusion diagnosis antigen for African swine fever virus as well as preparation method and application thereof
An African swine fever virus and fusion antigen technology, applied in the biological field, can solve the problems of low specificity and low sensitivity, and achieve the effect of high sensitivity and strong specificity
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[0066] The present invention will be further described in detail below through specific examples.
[0067] 1. Prediction and analysis of dominant antigenic epitopes of important antigenic genes of ASFV.
[0068] According to the whole genome sequence of ASFV (GenBank accession number: U18466.2), using biological online software ABCPred (http: / / www.imtech.res.in / raghava / abcpred / ), BepiPred 1.0 Server (http: / / www.cbs .dtu.dk / services / BepiPred / ), Immunomedicine Group (http: / / imed.med.ucm.es / Tools / antigenic.pl) and DNAStar-Protean software on ASFV important antigen genes (P72, P54, P30 and P12 ) to predict and analyze the epitope of the amino acid sequence encoded by ), and find the sequence with common dominant linear epitope by combining four different prediction methods (Table 1).
[0069] 2. Construction of ASFV multi-epitope fusion antigen gene.
[0070] Through the nucleotide sequence (GGCCCGGGC) encoding flexible amino acid (GPG), the genes encoding dominant antigenic epi...
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