11results about How to "Achieve kill" patented technology

The invention discloses a leachate treatment station for a household garbage incineration power plant, and relates to the field of garbage treatment.The leachate treatment station comprises a collection module, and the collection module comprises a collection pool; the ultraviolet treatment module comprises a pump body, a conveying pipe and an ultraviolet lamp tube, an outlet of the collecting tank is communicated with an inlet of the pump body, an outlet of the pump body is communicated with an inlet of the conveying pipe, the conveying pipe is transparent, the ultraviolet lamp tube is arranged on the conveying pipe, and the ultraviolet lamp tube is arranged on the pump body. The ultraviolet lamp tube extends along the length direction of the conveying pipe; the outlet of the conveying pipe is communicated with the inlet of the membrane treatment module, and the beneficial effects are that when the percolate flows in the transparent conveying pipe, the ultraviolet lamp tubes extending along the length direction of the conveying pipe are turned on and emit ultraviolet rays at the same time, so that microorganisms in the percolate are killed and inhibited; the purpose of preliminarily purifying the leachate is achieved, ultraviolet treatment on the leachate is achieved in the leachate flowing and conveying process, the occupied area is reduced, and the treatment efficiency is improved.

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The telescopic movable cleaning bin comprises a front moving table, a rear moving table and a telescopic cover arranged between the front moving table and the rear moving table, and a closed space is formed between the interior of the telescopic cover and the front moving table and between the interior of the telescopic cover and the rear moving table. An air outlet pipe facing the closed space and an air outlet fan connected with the air outlet pipe are arranged in the front moving table, and an air return pipe facing the closed space and an air return fan connected with the air return pipe are arranged in the rear moving table. A disinfection cabinet facing the closed space is installed on the front moving table or the rear moving table, and a sealing door capable of opening the closed space is installed on the front moving table or the rear moving table. According to the invention, the problem of germ diffusion in the process of tidying and replacing bedclothes, bed sheets and hospital clothes in a sterile space can be solved.

Provided are a universal T cell (CNK-UT) and an application thereof. The CNK-UT has the broad-spectrum ability to recognize and kill tumor cells and virus-infected cells.

The present invention discloses a microneedle patch loaded with dacarbazine and manganese salt, a preparation method thereof, and an application in the treatment of melanoma, wherein the microneedle patch comprises a back-symmetric layer and a needle array arranged on the back-symmetric layer, wherein the back-symmetric layer and the needle array are both formed by an aqueous solution of a degradable polymer, and dacarbazine and manganese salt are loaded in the aqueous solution of the degradable polymer used to form the needle array. The drug-loaded microneedles obtained by the present invention can effectively inhibit the growth and metastasis of tumors, effectively prevent the recurrence of tumors, and achieve efficient killing of melanoma.

The application provides application of sorafenib in preparation of a product for inhibiting Neisseria gonorrhoeae, and relates to the technical field of biology and bacteriostasis. The application comprises application of sorafenib or a derivative thereof in (I) preparation of a Neisseria gonorrhoeae inhibitor; or (II) preparation of a medicine for preventing, relieving and / or treating Neisseria gonorrhoeae; a medicine for treating or preventing infection and / or complications caused by Neisseria gonorrhoeae; a method for inhibiting or preventing growth of Neisseria gonorrhoeae; and the application provides a new potential medicine selection for treating drug-resistant gonorrhea, and has important clinical application value.

The present invention relates to the field of biomedicine, and in particular to an isolated TCR and its use. The TCR of the present invention comprises a TCR α chain and a TCR β chain, wherein the TCR α chain comprises CDRα1, CDRα2 and CDRα3 in the variable region of the TCR α chain; the TCR β chain comprises CDRβ1, CDRβ2 and CDRβ3 in the variable region of the TCR β chain; the amino acid sequence of the CDRα3 is shown in SEQ ID NO.2, and the amino acid sequence of the CDRβ3 is shown in SEQ ID NO.1. The TP53-R248Q-TCR of the present invention is stably expressed in CD8 + The TP53-R248Q-TCR-T cells prepared after T cells can specifically recognize and kill tumor cells expressing HLA-A*11:01 and TP53-R248Q mutant antigens. This invention will provide a solid theoretical and experimental basis for the development of TCR-T therapy targeting TP53-R248Q tumor neoantigens.

The invention belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, and particularly relates to a core-shell structure sequential drug release system for cascade deep penetration and induced differentiation treatment, construction of the core-shell structure sequential drug release system and application of the core-shell structure sequential drug release system in a drug delivery system. The system is of a shell-core structure, an inner core is nanoparticles which encapsulate an induced differentiation agent and have hypoxia response capability, and a shell is an acid response reversible polymer loaded with chemotherapeutic drugs. According to the invention, a pulse drug release strategy is utilized to overcome penetration obstacles of solid tumors, programmed drug release is carried out aiming at heterogeneity distribution of different cells in the tumors, a tumor microenvironment characterized by chemotherapy drug resistance and immune escape is effectively remodeled, and comprehensive inhibition of the tumors is realized.

This invention discloses a manure transportation system for healthy beef cattle farming, comprising a first deodorization device, a second deodorization device, and a separation device. The first deodorization device has a first pipe and a manure transportation pipe on its side, and is connected to the second deodorization device via the first pipe. A booster pump is installed above the second deodorization device. The separation device is located below the second deodorization device and contains a dehydration tank. A pneumatic device is installed at the lower end of the separation device, and its air inlet is connected to the second deodorization device via the second pipe. The separation device has a drainage pipe connected to a biogas digester. A first valve is installed on the first pipe, and a second valve is installed on the second pipe. Using this invention, solid-liquid separation and deodorization of the manure are achieved throughout the transportation process, reducing the environmental impact during transportation.

The invention provides a fluorescent carbon nanodot with an I-type PDT effect as well as a preparation method and application of the fluorescent carbon nanodot, and belongs to the technical field of material chemistry. The fluorescent carbon nanodots with the I-type PDT effect are obtained by taking chlorhematin of a biological source as a raw material, carrying out simple and convenient solvothermal reaction, dialyzing to remove impurities and drying. The nanodot is uniform in size, stable in fluorescence emission, good in biocompatibility, low in toxicity and good in I-type PDT effect, and can be widely applied to I-type PDT or combined treatment under the guidance of accurate imaging of hypoxia tumors.

The invention discloses a pyroelectric nano-particle based on a black phosphoryl-Fe < 3 + > complex as well as a preparation method and application of the pyroelectric nano-particle. The pyroelectric nanoparticle comprises a cell membrane and a black phosphorus-Fe < 3 + > complex wrapped in the cell membrane. The preparation method comprises the following steps: uniformly shaking the cell membrane and the black phosphoryl-Fe < 3 + > complex in an air bath, and extruding by using a liposome extruder. Under laser on / off irradiation, the prepared nano-particles are triggered by temperature change to generate pyroelectric catalysis for water decomposition in tumor intercellular fluid, aggregation of the nano-drug at a tumor site is improved, tumor cells are further efficiently killed, and in the catalysis process, along with generation of oxygen and ROS, polarization of tumor-related macrophages is further induced, so that the tumor-related macrophages are effectively killed, and the tumor-related macrophages are effectively killed. Anti-tumor immune response is activated, and tumor recurrence and metastasis are inhibited.