3results about How to "Achieve kill" patented technology

The application belongs to the technical field of biological medicine, and discloses an in-situ vaccine type mRNA-tLNP preparation for solid tumor treatment and preparation and application thereof. The preparation is designed by double targets, so that CAR-T kills more tumor cells to overcome tumor heterogeneity, changes the tumor immune microenvironment through autocrine fusion proteins (anti-PD-1 scFv and TGFbetaRII, IL-15 and Flt3L, CD40L), promotes T cell proliferation, and recruits and activates dendritic cells, cross-presents new antigens in the tumor local part, and produces in-situ vaccination effects; circular RNA encoding the above proteins is prepared, and the circular RNA is wrapped by lipid nanoparticles modified by CD3 antibodies, so as to be directly delivered to the body, and a significant solid tumor treatment effect is produced.

The application provides application of sorafenib in preparation of a product for inhibiting Neisseria gonorrhoeae, and relates to the technical field of biology and bacteriostasis. The application comprises application of sorafenib or a derivative thereof in (I) preparation of a Neisseria gonorrhoeae inhibitor; or (II) preparation of a medicine for preventing, relieving and / or treating Neisseria gonorrhoeae; a medicine for treating or preventing infection and / or complications caused by Neisseria gonorrhoeae; a method for inhibiting or preventing growth of Neisseria gonorrhoeae; and the application provides a new potential medicine selection for treating drug-resistant gonorrhea, and has important clinical application value.

This invention discloses a manure transportation system for healthy beef cattle farming, comprising a first deodorization device, a second deodorization device, and a separation device. The first deodorization device has a first pipe and a manure transportation pipe on its side, and is connected to the second deodorization device via the first pipe. A booster pump is installed above the second deodorization device. The separation device is located below the second deodorization device and contains a dehydration tank. A pneumatic device is installed at the lower end of the separation device, and its air inlet is connected to the second deodorization device via the second pipe. The separation device has a drainage pipe connected to a biogas digester. A first valve is installed on the first pipe, and a second valve is installed on the second pipe. Using this invention, solid-liquid separation and deodorization of the manure are achieved throughout the transportation process, reducing the environmental impact during transportation.