Method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization

Abstract

The invention relates to a method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization. The method comprises the following steps of: enabling levamisole hydrochloride aqueous solution as a raw material to enter a rectifying tower by adopting a continuous medium feeding mode, wherein the tower top has the temperature of 99-102 DEG C and the tower reactor has the temperature of 124-127 DEG C; separating the raw material, wherein component on the tower top is water and the component in the tower reactor is levamisole hydrochlorid enrichment solution with the content of more than 85 percent and the yield of more than 89.9 percent; condensing the levamisole hydrochloride enrichment solution and crystallizing in a continuous drum crystallization device at a crystallization temperature controlled between 4 DEG C below zero and 3 DEG C below zero for 0.3-0.5h, extracting the crystal, filtering and drying to obtain a finished levamisole hydrochloride product with the concentration of more than 99 percent and the yield of 98.7 percent.

Description

technical field [0001] The invention relates to a method for separating and crystallizing levamisole hydrochloride in pharmaceutical chemical industry, in particular to a method for extracting levamisole hydrochloride from levamisole hydrochloride aqueous solution by integrating continuous rectification and drum crystallization. Background technique [0002] Levamisole hydrochloride is the L-body of tetramisole, which can selectively inhibit the succinate dehydrogenase in the muscle of the worm, so that the fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscle of the worm and reducing energy production. When the worms come into contact with it, it can depolarize the neuromuscular, and the muscles continue to contract and cause paralysis; the cholinergic effect of the drug is conducive to the discharge of the worms. Its activity is about 1-2 times that of tetramisole (racemate), but its toxic and side effects are relatively ...

AI Technical Summary

Problems solved by technology

Due to the three-step crystallization method of room temperature crystallization, water crystallization and frozen brine crystallization, the crystallization speed is slow, and with the change of air temperature and water temperature, the crystallization process is difficult to control, resulting in fluctuations in the water content of the finished crystal

Apparently, in order to obtain levamisole hydrochloride in the traditional process, the production operation is inconvenient, the quality stability is poor, and the energy consumption is large.

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