Method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization

A technology for levamisole hydrochloride and crystallization, which is applied in the field of continuous rectification and drum crystallization integrated extraction of levamisole hydrochloride, can solve the problems of poor quality stability, high energy consumption, difficult control of crystallization process, etc., and achieves simple operation, high yield, high purity effect

Inactive Publication Date: 2011-05-18
江苏沿江化工资源开发研究院有限公司
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AI Technical Summary

Problems solved by technology

Due to the three-step crystallization method of room temperature crystallization, water crystallization and frozen brine crystallization, the crystallization speed is slow, and with the change of air temperature and water temperature, the crystallization process is difficult

Method used

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  • Method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization
  • Method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization
  • Method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization

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Embodiment 1

[0024] Embodiment 1, according to the continuous rectification of the present invention and the continuous drum crystallization integration method for extracting high-purity levamisole hydrochloride from levamisole hydrochloride aqueous solution, its process flow refers to figure 1 , figure 2 .

[0025] Described method comprises the following steps:

[0026] (1). Adopting the continuous feeding mode in the middle section of the tower, the raw material levamisole hydrochloride aqueous solution is squeezed into the tower still of the rectifying tower 4, and heating is started when the liquid level of the tower reaches 1 / 3; The plate number of distillation column is 5, and raw material levamisole hydrochloride aqueous solution feeds in the 3rd plate of continuous rectification column;

[0027] (2). When the temperature of the tower top and the kettle starts to stabilize and the rectification tower device reaches total reflux, the temperature of the tower top is 99-102°C, and ...

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Abstract

The invention relates to a method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization. The method comprises the following steps of: enabling levamisole hydrochloride aqueous solution as a raw material to enter a rectifying tower by adopting a continuous medium feeding mode, wherein the tower top has the temperature of 99-102 DEG C and the tower reactor has the temperature of 124-127 DEG C; separating the raw material, wherein component on the tower top is water and the component in the tower reactor is levamisole hydrochlorid enrichment solution with the content of more than 85 percent and the yield of more than 89.9 percent; condensing the levamisole hydrochloride enrichment solution and crystallizing in a continuous drum crystallization device at a crystallization temperature controlled between 4 DEG C below zero and 3 DEG C below zero for 0.3-0.5h, extracting the crystal, filtering and drying to obtain a finished levamisole hydrochloride product with the concentration of more than 99 percent and the yield of 98.7 percent.

Description

technical field [0001] The invention relates to a method for separating and crystallizing levamisole hydrochloride in pharmaceutical chemical industry, in particular to a method for extracting levamisole hydrochloride from levamisole hydrochloride aqueous solution by integrating continuous rectification and drum crystallization. Background technique [0002] Levamisole hydrochloride is the L-body of tetramisole, which can selectively inhibit the succinate dehydrogenase in the muscle of the worm, so that the fumaric acid cannot be reduced to succinic acid, thereby affecting the anaerobic metabolism of the muscle of the worm and reducing energy production. When the worms come into contact with it, it can depolarize the neuromuscular, and the muscles continue to contract and cause paralysis; the cholinergic effect of the drug is conducive to the discharge of the worms. Its activity is about 1-2 times that of tetramisole (racemate), but its toxic and side effects are relatively ...

Claims

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Application Information

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IPC IPC(8): C07D513/04
Inventor 顾正桂
Owner 江苏沿江化工资源开发研究院有限公司
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