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Anti-parasitic disease compound Triclabendazole granule for flocks and herds and preparation method for anti-parasitic disease compound Triclabendazole granule

A technology for compound triclbendazole and triclbendazole, which is applied to non-active ingredients in medical preparations, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as repeated attacks in groups and individual residues, and reduce recurrence efficiency, low cost, and the effect of improving taste

Inactive Publication Date: 2013-01-16
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when triclabendazole is used alone to treat cattle and sheep infected with fasciola, there are disadvantages of individual residues and repeated outbreaks in groups

Method used

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  • Anti-parasitic disease compound Triclabendazole granule for flocks and herds and preparation method for anti-parasitic disease compound Triclabendazole granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: (every bag packs 100g granules, the following examples are the same):

[0034] Triclobendazole 2.5kg

[0035] Levamisole hydrochloride 3 kg

[0036] Tiandixiang 1.5 kg

[0037] Aspartame 1 kg

[0038] Dextrin 30kg

[0039] Sucrose 20kg

[0040] Mannitol 2 kg

[0041] Starch 40kg

[0042] The raw materials of the compound triclabendazole granules involved in the present invention are triclabendazole and levamisole hydrochloride, wherein the alias of triclabendazole is: 5-chloro-6-(2,3-dichlorophenoxy base)-2-methylthio-1H-benzimidazole; another name for levamisole hydrochloride: (S)-(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1 -b] Thiazole hydrochloride.

[0043] The preparation method comprises the steps of:

[0044] ⑴ Make starch paste with 1 / 10 of the total amount of starch in the prescription, and set aside;

[0045] (2) Mix the prescribed amount of triclabendazole, levamisole hydrochloride, dextrin, sucrose, mannitol and remaining starch for 2...

Embodiment 2

[0051] formula:

[0052] Triclobendazole 5 kg

[0053] Levamisole hydrochloride 1 kg

[0054] Tiandixiang 3 kg

[0055] Aspartame 2 kg

[0056] Dextrin 20 kg

[0057] Sucrose 10 kg

[0058] Mannitol 0.5 kg

[0059] Starch 58.5kg.

[0060]

[0061] The steps of the preparation method are the same as in Example 1.

Embodiment 3

[0063] formula:

[0064] Triclobendazole 3.75 kg

[0065] Levamisole hydrochloride 1.5 kg

[0066] Tiandixiang 1.75 kg

[0067] Aspartame 1.5 kg

[0068] Dextrin 20 kg

[0069] Sucrose 10kg

[0070] Mannitol 1.5 kg

[0071] Starch 60kg

[0072] The preparation method is the same as in Example 1.

[0073]

[0074]Select 300 cattle, 300 sheep and 300 goats who were diagnosed as fascioliasis by feces examination and divide them into 3 groups, and 100 heads in each group were given compound triclabendazole granules (100g per bag mixed with 200kg of water, mixed drink ); triclabendazole granules (100g per bag mixed with 200kg of water, mixed with drink); levamisole hydrochloride tablets (take 100 tablets, crushed, mixed with 200kg of water, mixed with drink), medication for 15 days, before and after medication Detect once every 5 days, take the average value and enter it into the following table, calculate its effective rate for anti-fasciola, and retest the fecal eggs of ...

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Abstract

The invention belongs to the technical field of drug preparation and particularly relates to an anti-parasitic disease compound Triclabendazole granule for flocks and herds and a preparation method for the anti-parasitic disease compound Triclabendazole granule. The anti-parasitic disease compound Triclabendazole granule for the flocks and herds comprises the following components in parts by mass: 2.5-5 parts of Triclabendazole, 1-3 parts of levamisole hydrochloride and the balance auxiliary material. Compared with the prior art, the anti-parasitic disease compound Triclabendazole granule for the flocks and herds has the beneficial effects that as the Triclabendazole and the levamisole hydrochloride are combined for use, a disinsectization effect is better than that achieved by the addition of single components in the same proportion. Moreover, the recurrence rate is obviously reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a compound triclabendazole granule for anti-parasitic disease for cattle and sheep and a preparation method thereof. Background technique [0002] Triclobendazole is a drug specially used against Fasciola hepatica among benzimidazoles, and it has obvious killing effect on Fasciola hepatica of various ages. It is effective against ruminants such as cattle, sheep and goats, Fasciola hepatica, Fasciola cerevisiae, Fasciola deer liver, Fasciola large deer and Fasciola horse liver. This product is easily absorbed from the gastrointestinal tract when taken orally. The bioavailability is high, and the blood drug peak of goats and sheep is 24-36 hours after oral administration of triclabendazole, and the blood drug peak value of its prototype and its metabolites is 5-20 times that of other benzimidazole anthelmintics. Most of this product is oxidized into sulfoxide, sulfon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/429A61K47/46A61K47/36A61K47/26A61K9/16A61P33/10A61K31/4184
Inventor 元军英范培柱要瑞丽范培松
Owner TIANJIN BIJIA PHARMA CO LTD
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