Compound neomycin sulfate oral liquid for treating severe diarrhea of poultry and preparation method thereof

A technology of neomycin sulfate and oral liquid, which is applied in the field of veterinary medicine, can solve the problems of affecting chicken growth and egg production rate, loss of selective absorption function, and reducing chicken production performance, so as to achieve high oral bioavailability and pollution Small and easy to industrialize

Inactive Publication Date: 2013-01-23
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the damage of the intestinal tract, the loss of selective absorption function, the inhalation of poisonous substances into the blood and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the compound neomycin sulfate oral liquid for the treatment of poultry severe diarrhea of ​​the present invention comprises the following components according to the ratio in parts by weight: 8 parts of neomycin sulfate, 3 parts of berberine hydrochloride, 1 part of lactic acid TMP, injection 10 parts of astragalus polysaccharide, 2 parts of levamisole hydrochloride, 5 parts of acetaminophen, 60 parts of water for injection.

[0019] The preparation method of compound neomycin sulfate oral liquid comprises the following steps:

[0020] (1) First add 2 / 3 of the purified water or water for injection at 60°C;

[0021] (2) Add in sequence according to the order of the recipes, and stir until completely dissolved while adding;

[0022] (3), add purified water or water for injection to the full amount, and flush into nitrogen while stirring;

[0023] (4), add full amount of 0.05% activated carbon for needles, and decolorize for 20 minutes under stirring;

[0...

Embodiment 2

[0027] Embodiment 2: the compound neomycin sulfate oral liquid for the treatment of poultry severe diarrhea of ​​the present invention comprises the following components according to the ratio in parts by weight: 15 parts of neomycin sulfate, 6 parts of berberine hydrochloride, 3 parts of lactic acid TMP, injection 20 parts of astragalus polysaccharide, 4 parts of levamisole hydrochloride, 15 parts of acetaminophen, and 80 parts of water for injection.

[0028] The preparation method of compound neomycin sulfate oral liquid comprises the following steps:

[0029] (1) First add 70°C purified water or water for injection of 2 / 3 of the preparation amount;

[0030] (2) Add in sequence according to the order of the recipes, and stir until completely dissolved while adding;

[0031] (3), add purified water or water for injection to the full amount, and flush into nitrogen while stirring;

[0032] (4), add full amount of 0.2% activated carbon for needles, and decolorize for 30 minu...

Embodiment 3

[0036] Embodiment 3: the compound neomycin sulfate oral liquid for the treatment of poultry severe diarrhea of ​​the present invention comprises the following components according to the ratio in parts by weight: 13 parts of neomycin sulfate, 4 parts of berberine hydrochloride, 2 parts of lactic acid TMP, injection 13 parts of astragalus polysaccharide, 3 parts of levamisole hydrochloride, 10 parts of acetaminophen, and 70 parts of water for injection.

[0037] The preparation method of compound neomycin sulfate oral liquid comprises the following steps:

[0038] (1), first add 2 / 3 of the 65 ℃ purified water or water for injection;

[0039] (2) Add in sequence according to the order of the recipes, and stir until completely dissolved while adding;

[0040] (3), add purified water or water for injection to the full amount, and flush into nitrogen while stirring;

[0041] (4), add full amount of 0.10% active carbon for needles, decolorize under stirring for 20-30 minutes;

[...

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PUM

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Abstract

The invention discloses compound neomycin sulfate oral liquid for treating severe diarrhea of poultry. The oral liquid comprises the following components in parts by weight: 8 to 15 parts of neomycin sulfate, 3 to 6 parts of berberine hydrochloride, 1 to 3 parts of lactate TMP, 10 to 20 parts of injection astragalus polysaccharide, 2 to 4 parts of levamisole hydrochloride, 5 to 15 parts of acetaminophen, and 60 to 80 parts of injection water. The compound neomycin sulfate oral liquid for treating the severe diarrhea of the poultry is applied to the poultry, and is used for Gram-negative bacteria-induced gastrointestinal severe infection of the poultry and used for treating enteritis and diarrhea of the poultry. By using the oral liquid for treating escherichia coli infection and unknown severe diarrhea of the poultry, the significant efficiency is 94.1 percent, and the effective rate is 99.8 percent. The oral liquid is reasonable in formula compatibility, high in defecation level, low in dust content, low in pollution, high in oral bioavailability and convenient for industrialization.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a compound neomycin sulfate oral liquid for treating poultry severe diarrhea caused by Gram-negative bacteria in severe infection of poultry gastrointestinal tract and a preparation method thereof. Background technique [0002] At present, the state restricts the use of veterinary drugs more and more strictly. The "Specifications for the Use of Feed Drug Additives" issued by the Ministry of Agriculture specifically stipulates the use objects, uses, and drug withdrawal periods of 54 types of feed drug additives such as aureomycin premix and bacitracin zinc premix. In the Veterinary Drug Prohibition List, the use of β-stimulants such as clenbuterol, sex hormones such as diethylstilbestrol, substances with estrogen-like effects such as zearalenol, chloramphenicol and other substances with estrogen-like effects are completely prohibited or restricted. 21 types of drugs i...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K9/08A61P1/12A61P31/04A61K31/7036A61K31/167A61K31/429A61K31/437
Inventor 王磊
Owner TIANJIN BIJIA PHARMA CO LTD
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