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Freeze-dried vaccine drinking water immune protective agent for chicken and preparation method thereof

A technology of immune protection and protective agent, which is applied in the field of veterinary medicine, can solve the problems of interference, reduced activity of freeze-dried vaccines, poor stability and protective function, etc., and achieve the effect of drug residue, no drug residue, and good protective effect

Inactive Publication Date: 2016-03-30
TIANJIN HLINTE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the 21st century, my country's vaccines are a century of rapid take-off. Not only have a large number of fire-fighting vaccines and attenuated vaccines for bacteria and viruses been developed, but also genetically engineered vaccines have been produced, which have made great contributions to the development of animal husbandry. However, in recent years my country's vaccines are facing new and huge difficulties in the development. At present, live freeze-dried vaccines account for a considerable proportion of animal vaccines. The commonly used protective agents in China are mainly milk, sucrose, and gelatin. Although they have a stable appearance and good solubility , low cost, easy to store, but poor stability and protective function, easy to decompose in water after dissolving in water, resulting in reduced activity of freeze-dried vaccines, easily interfered by minerals in water, so it is necessary to invent a drinking water protectant for freeze-dried seedlings Undoubted subject

Method used

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  • Freeze-dried vaccine drinking water immune protective agent for chicken and preparation method thereof
  • Freeze-dried vaccine drinking water immune protective agent for chicken and preparation method thereof
  • Freeze-dried vaccine drinking water immune protective agent for chicken and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A freeze-dried vaccine drinking water immunoprotective agent for chickens. The components and weights of the immunoprotective agent are: 5 grams of levamisole hydrochloride, 10 grams of mannose, 20 grams of lactose, 5 grams of n-octanoic acid, and Tween-802 grams. .

[0022] A preparation method of a freeze-dried seedling drinking water immunoprotective agent for chickens, and the steps of the preparation method are:

[0023] (1) Weigh levamisole hydrochloride, mannose, and lactose according to the weight ratio, crush them, put them through a 200-mesh sieve, then mix in a three-dimensional mixer, take out in 25 minutes, and obtain mixture A, which will be used for later use;

[0024] (2) Weigh n-octanoic acid and Tween-80 according to the weight ratio, mix them, and mix them with the mixture A obtained in step (1) to obtain the mixture B, which is ready for use;

[0025] (3) The mixture B obtained in step (2) is spray-dried in a spray dryer to obtain a finished product of a fre...

Embodiment 2

[0027] A freeze-dried vaccine drinking water immunoprotective agent for chickens. The components and weights of the immunoprotective agent are: levamisole hydrochloride 5 grams, mannose 12 grams, lactose 40 grams, n-octanoic acid 8 grams, and Tween-803 grams. .

[0028] The steps of the preparation method are the same as in Example 1.

Embodiment 3

[0030] A freeze-dried vaccine drinking water immune protectant for chickens, the components and weights of the immune protectant are: levamisole hydrochloride 10g, mannose 30g, lactose 50g, n-octanoic acid 10g, Tween-805g .

[0031] The steps of the preparation method are the same as in Example 1.

[0032] A protective agent for drinking water of freeze-dried seedlings for chickens, which can be widely used in preparation of livestock and poultry breeding.

[0033] The following experiments further verify the effectiveness of the present invention:

[0034] 21-day-old broilers, Newcastle disease H120, 1,000 birds per branch, drinking water, using the present invention at a ratio of 0.5%, comparing the effects of water temperature, pH, and heavy metals, and stabilizing titers.

[0035] Impact Table of Newcastle Disease Antigen Test Titer

[0036]

[0037] This group of experiments proved that drinking water using the freeze-dried vaccine of the present invention is not affected by water ...

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Abstract

The invention relates to a freeze-dried vaccine drinking water immune protective agent for chicken and a preparation method thereof. The immune protective agent comprises the following components by weight: 5-10 parts of levamisole hydrochloride, 10-30 parts of mannose, 20-50 parts of lactose, 5-10 parts of n-caprylic acid, and 2-5 parts of Tween-80. The protective agent provided by the invention can regulate water quality, eliminate the interference of ions in water to vaccines, inhibit the combination of calcium ions and sodium ions with vaccines, has very good preventive and protective effects on the influence of various causes on freeze-dried vaccines in water, has no toxic or side effect, also does not produce drug residue, is convenient to use and low in cost, plays a very good role in the use of various freeze-dried vaccines in culture, and is a cheap freeze-dried vaccine protective agent simple to use.

Description

Technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a freeze-dried seedling drinking water immune protective agent for chickens and a preparation method thereof. Background technique [0002] my country is a large breeding country, the amount of livestock and poultry breeding ranks first in the world, accounting for 2 / 3 of the world. In recent years, China's aquaculture has been continuously transforming to scale, intensification and mechanization. With the continuous and healthy development of the breeding industry, the breeding level of chicken farmers is also changing with each passing day. In the 21st century, China’s vaccines are taking off rapidly. Not only have a large number of bacteria and virus fire-fighting vaccines and attenuated vaccines been developed, but also genetically engineered vaccines have been produced, which have made great contributions to the development of animal husbandry. But in recent years China’s vac...

Claims

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Application Information

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IPC IPC(8): A61K47/26A61K47/22A61K47/12
Inventor 陈庆忠安同伟曹桂敏
Owner TIANJIN HLINTE BIOTECH CO LTD
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