This invention provides a method for preparing and applying a long-acting
anthelmintic compound microcapsule. The long-acting
anthelmintic compound microcapsule is composed of a component containing an
anthelmintic drug,
white petrolatum, and
pollen microcapsules; the
anthelmintic drug content is 10-30 wt% of the total weight. Based on a unique
supercritical carbon dioxide mixing process, this invention achieves efficient loading of the anthelmintic agent into the
pollen microcapsules under mild conditions. This process further utilizes the porous nature of the microcapsules to achieve sustained release of the anthelmintic agent, thereby effectively prolonging the duration of action. Furthermore, thanks to its micron-sized structure, the microcapsule ensures that the anthelmintic component acts only on the
body surface, preventing it from penetrating the
skin, thus significantly improving the safety of use.