30 results about "Anthelmintic drug" patented technology

Disclosed in the present invention are a triazine derivative, a preparation method therefor and the use thereof, belonging to the technical field of drug synthesis. Specifically, disclosed in the present invention are a triazine derivative represented by general formula (I), a pharmaceutical composition containing the triazine derivative, and the use thereof in the preparation of an anthelmintic drug for humans or animals. The general structural formula (I) of the triazine derivative is shown as follows. The triazine derivative of the present invention has a significant effect in resisting zoonotic helminths such as nematodes and heartworms, and has a broad application prospect.

The invention belongs to the technical field of pet products, and particularly discloses a novel anthelmintic based on fipronil drops, which can effectively reduce the bacterial or fungal infection caused by parasites on the body surface or skin of pets by combining the antibacterial effects of fipronil, citronella extract and tripterygium wilfordii. The fipronil can quickly kill parasites, the citronella extract can further reduce breeding and contact of the parasites through a repelling effect, so that the overall effect of the medicine is accelerated, the citronella extract further reduces the secondary infection risk caused by the parasites by inhibiting growth of bacteria, and the tripterine further reduces the secondary infection risk caused by the parasites by inhibiting pathogenic microorganisms of skin. Through the synergistic effect of multiple components, the development of drug resistance of parasites to a single component can be reduced.

The invention relates to an insect repellent preparation as well as a preparation method and application thereof, and the insect repellent preparation comprises the following components: fluralan, a flavoring agent, a surfactant, a phagostimulant, a lubricant, a forming agent and a filler. The phagostimulant is a mixture of chicken powder, chicken heart powder and chicken liver powder, and the mass ratio of the chicken powder to the chicken heart powder to the chicken liver powder is 1: (1-3): (0.5-1.5). The flurala chewable tablets comprise the following components in parts by mass: 10-25 parts of flurala, 5-15 parts of a flavoring agent, 0.1-5 parts of a surfactant, 5-40 parts of a phagostimulant, 10-40 parts of a lubricant, 10-35 parts of a forming agent and 10-30 parts of a filling agent. The fluralan insecticide is good in stability, high in safety, good in curative effect, simple and convenient in preparation method and suitable for large-scale production.

The invention relates to a composition for use in the oral treatment of nemathelminthiasis, said composition comprising eleganolone and / or a bifurcanol-type linear diterpene, and a process for preparing a corresponding anthelmintic.

The utility model discloses an insect repellent device for kiwifruit planting, comprising an unmanned aerial vehicle (UAV) body, a medicine storage box being arranged below the UAV body, a spraying mechanism being arranged on the UAV body, the spraying mechanism comprising a supporting frame, a connecting piece, a conveying pipe, a nozzle and a water pump, the supporting frame being mounted on the UAV body, the connecting piece being provided with a plurality of groups mounted on the supporting frame, the conveying pipe being mounted on the connecting piece, the nozzle being mounted on the bottom end of the connecting piece, the water pump being mounted on one side of the connecting piece, a medicine extraction mechanism being arranged below the medicine storage box, the medicine extraction mechanism comprising a vacuum pump, a fixed pipe, a connecting pipe, a threaded pipe and a medicine extraction head, the vacuum pump being mounted on the bottom surface of the medicine storage box, so as to solve the technical problems mentioned in the background technology that the spraying of the insect repellent is uneven, errors are likely to occur when the insect repellent is added manually, and the mixing of the insect repellent and water in the medicine storage box is uneven.

The utility model discloses a composite wardrobe with insect prevention and drying functions, which belongs to the technical field of wardrobes and comprises a protective cabinet, a drying component is arranged at the top of the protective cabinet, a first partition plate is fixedly connected to the inner side of the protective cabinet, and second partition plates are arranged on the first partition plate and the inner side of the protective cabinet. The combined type wardrobe with the insect prevention and drying functions has the advantages that by arranging the drying assembly, the interior of the protection cabinet can be conveniently heated and dried, clothes can be dried, meanwhile, moisture-proof treatment can be conducted on the clothes, by arranging a lap joint roller, the clothes can be conveniently dried, and the drying effect is good. According to the clothes hanger, clothes can be conveniently placed in a lap joint mode, by arranging the storage box, insect repelling drugs can be placed, the insect repelling effect can be achieved to a certain degree, the insect prevention efficiency is guaranteed, by arranging the supporting base, the structure can be supported and lifted, and insect entering can be reduced.

The utility model relates to the technical field of anthelmintics, and discloses a feed anthelmintics blending and mixing device which comprises a mixing barrel, a feeding pipe and a discharging pipe are arranged on one side of the upper end of the mixing barrel and the middle of the lower end of the mixing barrel respectively, a barrel cover is detachably arranged at the upper end of the mixing barrel, a pesticide feeding pipe is arranged above the barrel cover, and a stirring shaft is rotatably connected to the middle of the lower portion of the barrel cover. The stirring shaft is driven by a motor fixedly arranged above the barrel cover, a spiral stirring blade is fixedly arranged on the stirring shaft, a square stirring frame is arranged on the stirring shaft and located on the outer side of the spiral stirring blade, a plurality of stirring blocks are arranged on two side plates of the square stirring frame, and a plurality of barrier strips are arranged on the inner wall of the mixing barrel. The stirring device has the advantages that the stirring effect on feed and anthelmintic is good, the uniformity is high, and the situation that the local drug content is too high is prevented.

The invention provides a bow roundworm infection animal model as well as an establishment method and application thereof, and aims to establish a stable and repeatable bow roundworm infection animal model and explore the application value of the bow roundworm infection animal model. By optimizing the egg separation and culture technology, the development rule of infectious eggs is determined; a quantitative infection strategy is adopted to dynamically monitor worm egg discharge dynamics, clinical symptoms and blood index changes, and the reliability of the model is comprehensively evaluated; the model is further utilized to perform curative effect verification on a commercial anthelmintic drug Blein, and the result shows that the constructed animal model infected by the cat head roundworm can be used for drug effect evaluation.

A plateau railway engineering disturbance key protection plant protection technology is characterized by specifically comprising the following steps that forest land areas needing to be classified are selected, and needed data are obtained; performing field investigation on the key protected plants, and recording specific data; setting water and soil conservation measures; placing a water-soluble graphene plant growth promoter; placing an insect repellent; hanging a signboard; and setting a protection range. According to the invention, the water-soluble graphene plant growth agent, the insect repellent and water and soil conservation measures are combined, so that key protection plants are protected. The method provided by the invention has a remarkable protection effect on key protection plants interfered by engineering in high-altitude areas.

The utility model belongs to the technical field of parasite expelling medicine bag distribution, and particularly relates to a wild animal parasite expelling medicine bag distributor which comprises a supporting frame and a supporting rod, and the supporting rod is fixedly connected to the top of the supporting frame. Through the arrangement of the distribution device, when the stress block moves towards the outer side of the material box to the end in advance, the stress plate does arc-shaped movement downwards under the action of the sleeve and the circular shaft without the support of the material box, so that the insect repellent placed in the moving plate falls to the ground, and when the stress block resets, the material box is not supported by the material box. The stress plate can be reset under the supporting force again, the anthelmintic falling on the ground can be licked and rubbed by the walking wild animals, so that the anthelmintic effect on the wild animals is achieved, and the problem that the anthelmintic placed in the moving plate cannot fall on the ground and cannot be damaged is solved. The insect repellent medicine bag cannot fall on the ground to be licked and rubbed by the walking wild animals, and the insect repellent effect on the wild animals cannot be achieved.

The invention provides a green and efficient preparation method of an anthelmintic albendazole sulfoxide, which is characterized in that water is used as a green oxygen source, an anodic oxidation reaction is driven by electric energy at room temperature, albendazole sulfoxide is synthesized with high selectivity, and sulfone by-products generated by excessive oxidation are effectively avoided. According to the method, albendazole, cheap electrolyte sodium bromide, dimethyl sulfoxide and water are mixed into homogeneous reaction liquid, inert gas protection is not needed, and the homogeneous reaction liquid is introduced into an electrochemical microchannel continuous reactor to achieve oxidation. Compared with a traditional hydrogen peroxide oxidation method and a low-temperature chemical oxidation method, the method does not need to use a stoichiometric oxidizing agent, is mild in reaction condition, effectively avoids related safety and environmental risks, meets the requirements of green and sustainable development, and has a good industrial application prospect.

The present invention relates to a composition for use in a method of treating a liver disease, preferably metabolic dysfunction-associated steatohepatitis (MASH). The composition comprises: • An effective amount of at least one saponin active ingredient (preferably ginsenoside or diosgenin) • And / or an effective amount of at least one anthelmintic (preferably niclosamide or nitazoxanide) • And / or an effective amount of at least one mitochondrial uncoupler.

The invention relates to an insect expelling heating method and an insect expelling device.The method comprises the steps that a heating instruction of a heating area is received, and the initial temperature of the heating area is obtained; performing preheating operation on the heating area to obtain the heating time of the heating area from the initial temperature to the target temperature and a corresponding time threshold value and / or obtain the target temperature of the heating area from the initial temperature to the target time and a corresponding temperature threshold value; determining a target heating area according to the heating time and a corresponding time threshold value and / or determining the target heating area according to the target temperature and a corresponding temperature threshold value, wherein the target heating area is a heating area in which an insect repellent tablet is placed; in response to the existence of the target heating area, executing a heating operation on the target heating area; and in response to the absence of the target heating area, the heating operation on the heating area is stopped, and an abnormal prompt is sent out, so that whether the insect repellent tablets exist in the heating area is intelligently judged, the heating efficiency is improved, the energy consumption is reduced, and the service life is prolonged.

The invention relates to the technical field of veterinary medicaments, in particular to a pharmaceutical preparation for improving stability and a preparation process thereof, and the pharmaceutical preparation comprises the following raw materials in parts by weight: 10-50 parts of veterinary active pharmaceutical ingredients, 3-15 parts of a stabilizer, 5-20 parts of a cosolvent, 15-40 parts of an excipient and 1-5 parts of a lubricant, the veterinary active medicine components comprise antibiotic medicines, insect repellent medicines, nutrition supplement medicines or antipyretic, analgesic and anti-inflammatory medicines. The particle size and purity of active ingredients are strictly controlled in the aspect of stability, the composite stabilizer has a synergistic effect, the overall stability is guaranteed through raw material pretreatment and a reasonable process, and the shelf life is prolonged. And the quality performance is improved, the dissolution is assisted by the cosolvent, the excipient ensures good molding, and the superfine grinding lubricant improves the flowability and is beneficial to production and processing. The medicine effect is fully exerted, the active ingredients efficiently act due to the good stability and dissolution performance, and the composition is suitable for the fields of various diseases and animals and wide in application range.

The invention relates to a method for synchronously determining an anthelmintic in a feed. The anthelmintic comprises three kinds of nitro-iodonitrile, rafoxanide and closantel. Comprising the following steps: S1, extracting a to-be-detected feed sample with acetonitrile to obtain a to-be-purified solution; s2, purifying the to-be-purified solution by adopting a Prime HLB solid-phase extraction column, collecting all effluent, fixing the volume by using water, uniformly mixing, and passing through a microfiltration membrane to obtain a to-be-purified sample solution. According to the method, acetonitrile is adopted to extract the anthelmintic in the feed, so that the recovery rate is high, and the repeatability is good; a Prime HLB solid-phase extraction small column is adopted to purify a sample, most lipids and other impurities in the feed can be removed, the method has good selectivity on target compounds, operation is easy and convenient, the steps of activation, balancing, impurity leaching and the like are not needed, the detection time is greatly shortened, and the detection efficiency is improved. The method fills the blank of the method for detecting the nitro-iododinitrile, the rafoxanide and the closantel in the feed at present, and can provide reliable technical support for feed quality safety monitoring.

The utility model discloses a body surface insect expelling necklace for animal husbandry, which is mainly applied to the technical field of animal husbandry articles, and comprises a necklace, a medicine box support, a medicine box base, a medicine box, an upper cover, a medicine adding channel, a rubber plug and a volatilization core, the middle part of the necklace is provided with a medicine box support groove, and the medicine box support is clamped in the medicine box support groove; a plurality of medicine box bases are fixedly connected to the medicine box support, medicine boxes are detachably connected into the medicine box bases, upper covers are detachably connected to the tops of the medicine boxes, platforms are arranged in the medicine boxes, through holes are formed in the centers of the platforms, volatilization cores are placed on the platforms, protrusions are arranged in the centers of the volatilization cores, and the protrusions extend to the bottoms of the medicine boxes. The body surface insect expelling necklace for livestock raising is scientific and reasonable in structural design, convenient and fast in medicine adding operation, high in efficiency, long in insect expelling time, safe and reliable, insect expelling medicine does not make direct contact with the body surface of livestock, medicine is used only through natural volatilization, and the insect expelling medicine can be prevented from harming the health of the livestock and being accumulated in the livestock.

This invention provides a method for preparing and applying a long-acting anthelmintic compound microcapsule. The long-acting anthelmintic compound microcapsule is composed of a component containing an anthelmintic drug, white petrolatum, and pollen microcapsules; the anthelmintic drug content is 10-30 wt% of the total weight. Based on a unique supercritical carbon dioxide mixing process, this invention achieves efficient loading of the anthelmintic agent into the pollen microcapsules under mild conditions. This process further utilizes the porous nature of the microcapsules to achieve sustained release of the anthelmintic agent, thereby effectively prolonging the duration of action. Furthermore, thanks to its micron-sized structure, the microcapsule ensures that the anthelmintic component acts only on the body surface, preventing it from penetrating the skin, thus significantly improving the safety of use.

The utility model discloses a veterinary drug grinding device which comprises a smashing box, three annularly-arranged supporting plates are fixedly installed on the upper surface of the smashing box, a mounting base is fixedly installed at the ends, close to each other, of the three supporting plates, a first bearing is fixedly embedded in the upper surface of the mounting base, and a second bearing is fixedly embedded in the upper surface of the mounting base. A rotating shaft is fixedly installed on the inner ring of the first bearing, a top plate is fixedly installed at the bottom end of the rotating shaft, and two vertical plates are fixedly installed on the bottom face of the top plate. According to the device, the upper surface of a top plate and the bottom end of a rotating shaft are fixedly installed, so that when the rotating shaft rotates, the top plate and two vertical plates below the top plate can be driven to rotate, and the two ends of a grinding roller are fixedly installed with inner rings of first bearings embedded in the right side faces of the two vertical plates correspondingly; and the two vertical plates can drive the grinding roller to roll above the filter plate when rotating, so that the grinding roller can grind the vermifuge into powder, and the device can effectively reduce the time cost of farmers.

The invention discloses a method for intervening growth of echinococcus multilocularis based on diapause pheromone Ascr # 18 and application, and belongs to the technical field of prevention and control of zoonosis parasitic diseases. According to the invention, the Ascr # 18 is identified in the echinococcus multilocularis through liquid chromatography-mass spectrometry (LC-MS) for the first time, and it is verified that the Ascr # 18 can be combined with a downstream G-protein coupled receptor (GPCR) in a high-affinity manner, and a signal channel is activated. After the Ascr # 18 is treated, the expression level of development key genes daf-9 and daf-12 in the protoscolex of the echinococcus multilocularis can be remarkably reduced, and the movement activity of the development key genes daf-9 and daf-12 is inhibited, so that the development process and infection ability of parasites are blocked. The invention provides a novel biological prevention and control strategy which does not depend on traditional chemical anthelmintic drugs, is high in targeting, high in safety, environment-friendly and controllable, is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and an application reference for prevention and control of other tapeworm and larva parasitic diseases.

The agricultural intelligent cultivator capable of improving the soil environment comprises a cultivator body, the rear end of the cultivator body is fixedly connected with an installation frame, the left end and the right end of the installation frame are both fixedly connected with supporting frames, and the upper ends of the two supporting frames are both rotationally connected with rotating bases through hinged shafts; the left end and the right end of the mounting frame are each provided with a deinsectization assembly, and one deinsectization assembly comprises an electric push rod, a rotating frame, a swing frame, a connecting strip, a plurality of flame guns and an air pipe. The foldable flame gun solves the problem that insects in farmland soil have drug resistance and further influence growth of crops, is reasonable in structure and good in practicability, and can effectively solve the problem of drug resistance of the insects in the farmland soil by killing the insects in the soil of the crops in batches through the foldable flame gun.

The present invention relates to the technical field of outdoor monitoring protection boxes, and in particular to an on-site protection box for an outdoor monitoring device, comprising a box, a motor is provided on the top of the box, a box door is provided on the front of the box, a driving component for driving away flying insects is provided on both sides of the box, each card shell is provided with an opening, and a fixing component for fixing and replacing a sticky tube is provided inside the opening of the card shell, two single-head gear rods are respectively provided with two knocking components, and each support plate is provided with two material boxes for containing insect repellents on the top, the two material boxes are fixed on both sides of the top of the support plate, each material box is provided with a slot for plugging a moving plate, the moving plate is plugged into the slot of the material box, and a ventilation window is provided inside the material box; the present invention can effectively prevent insects from entering the box through the coordinated use of the driving component, the buffer component and the knocking component, and can also prevent the vent from being blocked, and is easy to replace and repair.

The utility model provides a separation device for an insect repellent intermediate, which comprises a liquid storage tank, the inner wall of the liquid storage tank is fixedly connected with a filter cartridge, the inner wall of the filter cartridge is fixedly connected with a first fixed pressure plate, and the inner wall of the filter cartridge is fixedly connected with a second fixed pressure plate below the first fixed pressure plate. Compared with the prior art, the filter has the following beneficial effects that the two movable pressing plates are driven to synchronously rotate through the motor and the swing shaft, and in the process, the first fixed pressing plate and the second fixed pressing plate are matched to continuously extrude a material in the filter cartridge, and a liquid-phase material falls into the liquid storage tank from the filter cartridge; after solid-liquid separation is completed, the electric push rod is matched to enable the sealing cover to be far away from the discharging opening, the solid-phase material falls into the discharging groove from the discharging opening, finally, the liquid outlet pipe and the discharging pipe are opened, the solid-phase material and the liquid-phase material which are well separated can be obtained, and therefore separation of the intermediate is achieved; and the sealing performance between the sealing cover and the discharging opening is effectively improved through the compression spring.

The spraying device comprises a base, wheels are arranged at the bottom of the base, a pesticide box is arranged above the base, a material pumping box is arranged on one side of the base, a connecting pipe is arranged on one side of the material pumping box, and the connecting pipe is connected with the bottom of the pesticide box. The pesticide spraying device comprises a pesticide box, a mounting plate is arranged on one side of the upper portion of the pesticide box, a pesticide pumping pump is arranged on the inner side of the upper portion of the mounting plate, the pesticide pumping position of the pesticide pumping pump is connected with the interior of a pesticide pumping box, and a pesticide spraying pipe is arranged at the discharging position of the pesticide pumping pump. And during use, a worker holds a push rod by hand, and the push rod is driven to stretch out and draw back through a telescopic rod, so that different people can use the device conveniently, and the device is driven to move in cooperation with wheels, so that the device is more convenient to move.

The invention discloses a compound samipril preparation and a preparation method thereof, and belongs to the technical field of veterinary chemical preparations. The preparation is composed of samizuril, an iron (III) compound, a solvent, a cosolvent, a pH regulator and a bacteriostatic agent. The compound samizuril preparation has good stability and safety and is convenient to take. In the iron supplementing process of the piglets, the insect-resistant drug samizuril is added to effectively kill coccidiosis, the defect that an iron supplementing agent and an insect repellent can only be used independently is overcome, adverse reactions caused by iron supplementing agent injection are reduced, and the iron supplementing agent is good in bioavailability, outstanding in clinical effect and wide in application prospect.

The present application relates to a kind of isoxazoline anthelmintic preparation preparation method, comprising the following steps: S1. the raw material drug is weighed with solvent component;Wherein, solvent component includes antioxidant, cosolvent, flavouring agent and surfactant;S2. first, add surfactant, while stirring, add cosolvent, then cooling;S3. flavouring agent, antioxidant, raw material drug are sequentially added, and stirring is dissolved;S4. filter, fill and pack, and the preparation obtained in the application is orally administered, can be mutually soluble with water in any ratio, has good stability, high safety, good curative effect, greatly expands the clinical application range of isoxazoline anthelmintic preparation, and preparation method is simple, suitable for mass production.

The utility model relates to the technical field of medicine purification, and discloses a purification device of veterinary anthelmintic albendazole, which comprises a box body, the outer surface of the lower end of the box body is fixedly connected with supporting legs, the outer surface of the upper end of the box body is fixedly connected with a working tank, the inner surface of the upper end of the working tank is fixedly connected with a crusher, and the crusher is fixedly connected with a water pump. The outer surface of the upper end of the box body is provided with an extraction tank, the outer surface of the front end of the box body is provided with a wastewater collection pool, the outer surface of the front end of the box body is fixedly connected with an air cylinder, the inner surface of one side of a working tank is fixedly connected with a supporting rod, and the outer surface of one side of the supporting rod is fixedly connected with a dissolving tank. According to the crystal drying device, residues attached to the surface of a filter screen can be cleaned through the arranged filter assembly, the maintenance time is saved, crystals are dried for three times through the arranged drying assembly, the working efficiency of the device is improved, and a better use prospect can be brought.

The invention relates to the technical field of livestock breeding equipment, in particular to deinsectization and deinsectization equipment based on a broiler breeding shed, which comprises a base, a medicament barrel, a water pump, two groups of water pipes, a plurality of groups of nozzles, a movable spraying assembly and a swinging spraying assembly, the base is arranged on the side face of an external breeding shed frame. The medicament barrel and the water pump are respectively arranged on two sides of the surface of the base; one group of water pipes connects the medicament barrel with the water inlet end of the water pump, and the other group of water pipes is connected to the water outlet end of the water pump; the movable spraying assembly is arranged at the top end of the external breeding shed frame, and the multiple sets of nozzles are fixed to the surface of the movable spraying assembly in a scattered mode and connected with the branch ends of the water pipes. The movable spraying assembly drives the spraying head to transversely move back and forth along the breeding shed frame, the water pump conveys the pesticide in the pesticide barrel to the spraying head, automatic spraying of the insect repelling pesticide is completed through the movable spraying assembly, and the insect repelling efficiency is improved.

The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. daf-9 With daf-12 The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application provides a novel biological prevention and control strategy which is independent of traditional chemical deworming drugs, has high targeting, high safety, is environment-friendly and controllable, and is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and application reference for prevention and control of other cestode larva parasitic diseases.

The present invention relates to a method for determining the purity and impurities of Emendes intermediate 1 by high performance liquid chromatography, which belongs to the technical field of medicine. The technical solution is that the sample is prepared into a test solution by an appropriate method, methanol-tetrahydrofuran-water is used as the mobile phase, and the main component Emendes intermediate 1 and related impurities are separated on a pentafluorophenyl bonded silica column, and detected with a UV detector. This method can effectively separate the isomers of Emendes intermediate 1 and improve the efficiency of Emendes process optimization.