58 results about "Anthelmintic drug" patented technology

The invention discloses a preparation method for anthelmintic benzimidazole fenbendazole. The method is characterized in that: p-dichlorobenzene is used as a starting raw material which is subjected to nitration, amination, condensation, reduction and ring-closure reactions so as to obtain fenbendazole (the content of the final product being 98% to 101%). The novel preparation method has the characteristics of a simple and highly efficient process and safe operation, and is suitable for industrial production.

The invention discloses a new preparation method of an insect repellent albendazole and provides a brand-new synthesis route of albendazole. The new preparation method adopting m-dichlorobenzene as the starting material is used for obtaining high-purity albendazole through nitration, amination, condensation, reduction and cyclization reaction; the new preparation method is characterized in that an unstable intermediate condensation compound 2-nitryl-4-propyl sulfenyl aniline in the existing industrial route is changed into 2-nitryl-5-propyl sulfenyl aniline with stable quality. The reducing process is changed into a clean and efficient reducing process by virtue of sodium sulfide. The synthesis process is simple and efficient, less in pollution, high in quality and suitable for industrial production.

The invention discloses a method for preparing high-purity nemadectin and belongs to the field of medicinal chemistry. The nemadectin is a sixteen-member macrolide type anthelmintic antibiotic and mainly used for synthesizing moxidectin with the better anthelmintic effect. According to the method for preparing the high-purity nemadectin, the nemadectin is extracted through an ethanol-water solution, and an extract is obtained, decolorized through ion exchange resin, deproteinized and desugared through macroporous adsorption resin and finally adsorbed and separated through the appropriate macroporous adsorption resin, so that nemadectin products with the purity higher than 90% can be prepared. The method is high in pertinency through matched usage of the resin, and the prepared high-purity nemadectin has great significance in synthesis of the high-purity moxidectin.

The invention belongs to the technical field of chemical drug synthesis, and particularly relates to a preparation method of an isoxazoline insectifuge. The preparation method is characterized in thatthe isoxazoline insectifuge is fluralaner; an intermediate I is sequentially subjected to an amidation condensation reaction, a substitution reaction and a ring closing reaction in the same reactioncontainer; and after the reactions are finished, a reaction product is poured into water, stirring and filtering are conducted to obtain a solid, and the obtained solid is recrystallized to obtain theisoxazoline insectifuge. The method has the beneficial effects that the method uses a solvent and one-pot method to synthesize fluralaner, technological operation of a synthesis process is reduced, treatment time and reaction time are shortened, product yield is improved, and the method is suitable for large-scale production.

The invention discloses a new preparation method for anthelmintic fenbendazole, and provides a new synthetic route for fenbendazole. Fenbendazole is obtained by taking m-dichlorobenzene as a starting raw material through the reactions of nitration, amination, condensation, reduction and cyclization. The new preparation method is characterized in that m-chloroaniline serving as the starting raw material in the conventional industrial route is changed into m-dichlorobenzene which is low in cost; and a reduction process which uses sodium sulfide is changed into a clean and efficient reduction process. The new synthetic process is simple and efficient, low in pollution, high in quality and applicable to industrial production.

The present invention in general relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one active ingredient and at least one dicarboxylic acid. It in particular relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one anthelmintic drug and at least one dicarboxylic acid. The invention further relates to uses, methods for use and methods for manufacturing the pharmaceutical suspension according to this invention.

The invention provides a method for preparing an environmentally-friendly insect-preventing material and relates to a novel environmentally-friendly insect-preventing material based on plant composition and a preparation method thereof. The method comprises the following steps: rapidly drying and smashing fresh rhizomes, leaves, peels and seeds of a specific regenerating plant with a drug action, and preparing the dried and smashed substances according to a scientific ratio into a raw material; and integrating the raw material with other solidified materials by using a specific process and a slow-releasing technique, thus the active ingredients are released slowly and lastingly. The preparation process is simple and convenient, the raw material is easily available, the cost is low, the raw material can be industrially planted, and a novel occupation ideal of 'material farmer' is established. The insect-preventing material is safe to humans and animals, is ecologically environmentally-friendly and has a broad-spectrum parasite-expelling function, a long-acting drug action and an excellent effect. The insects hardly generate the resistance to drugs while the natural enemies of the insects are not hurt. By applying the environmentally-friendly insect-preventing material to the fields of agriculture and forestry, the damages to the living and growing capabilities of animals and plants caused by the plant diseases and insect pests are prevented, the environmentally-friendly organic food is produced, the environmental pollution problem caused by applying a large number of chemical pesticides is avoided, the food safety is strictly controlled from the source, the quality of agricultural products is increased, and the income of the famer is also increased.

The invention discloses an English name, molecular formula, structural formula, molecular weight, physical property and mass atlas of a novel veterinary drug triclabendazole sulfoxide. The novel veterinary drug triclabendazole sulfoxide is a novel imidazole anthelmintic drug and is an upgraded product of a veterinary drug insecticide triclabendazole. The novel veterinary drug triclabendazole sulfoxide has a remarkable insecticidal effect on both fasciola hepatica of ruminants, such as cattle, horses, sheep, goats, deer and the like, and fasciola gigantica of deer, and is low in toxic and side effects, and the usage and dosage are specified. Meanwhile, a preparation method of the triclabendazole sulfoxide is introduced. According to the method, 1,2,3-trichlorobenzene serves as a starting raw material, and the use of 2,3-dichlorophenol with strong sensitization and high price is avoided; and the requirements for reaction conditions are low, the product yield reaches 81.5%, the purity reaches over 99%, and no pollution is caused, so that the method is suitable for large-scale industrial production.

The invention relates to a method for preparation of a strong hydrophobic anthelmintic drug, i.e. an ivermectin sustained-release gelatin microcapsule by coacervation. The method includes: performing micronization treatment on ivermectin raw powder by processing so as to make the micropowder particle size meet the requirements of the prepared microcapsule particle size; then emulsifying the ivermectin in glycerin, dissolving sodium carboxymethyl cellulose in a gelatin solution, employing glycerin and sodium carboxymethyl cellulose to moderately adjust and strengthen the affinity and adsorption capacity of the main drug ivermectin and the cyst material gelatin; and then using sodium sulfate as a coagulant to make gelatin coagulate and deposit around capsule core particles so as to form a capsule membrane and achieve encapsulation.

The present invention provides a veterinary anthelmintic composition that includes: at least 10% w/v of a benzimidazole anthlemintic; and b) a water-immiscible solvent system, which comprises a lactone solvent, an essential oil, and surfactant.

The invention discloses a novel electric heating mosquito-repellent incense liquid, relates to the field of daily necessities, and aims to help sleep and judge the exhaustion time and the stability of the pesticide effect. The mosquito-repellent incense liquid is used for killing mosquitoes and comprises mosquito-repellent liquid medicine and a volatilization core. The mosquito-repellent liquid medicine comprises the following components in parts by weight: 20-30 parts of lavender essential oil, 90-110 parts of an organic solvent, 30-40 parts of a synergist, 10-15 parts of a surfactant, 10-15 parts of a stabilizer, 1-2 parts of a preservative, 1-2 parts of an antioxidant and 1-3 parts of an insect-repellent drug. According to the mosquito-repellent incense disclosed by the invention, a refreshing substance is replaced by lavender essential oil, so that the mosquito-repellent incense is fragrant and can help sleep, and whether mosquito-repellent incense liquid is used up or not can be judged according to the concentration of fragrance in air and the color of volatile liquid; and the organic solvent can dissolve organic compounds, the synergist can improve the pesticide effect, the surfactant can reduce the liquid surface tension, the stabilizer can maintain chemical balance, the preservative can delay corruption, the antioxidant can prevent oxidation, and the insect-repellent drug can kill mosquitoes.

The invention belongs to the technical field of chemical drug synthesis, and particularly relates to a synthesis method of an isoxazoline anthelmintic. The method is characterized in that the isoxazoline anthelmintic is fluralaner, and the method includes the steps of: carrying out substitution reaction, addition cyclization reaction and amidation condensation reaction on an intermediate I in a same reaction container sequentially; and after the reaction is finished, adding water and performing filtering, recrystallizing the obtained solid, and conducting filtering and airing to obtain the product. The method has the beneficial effects that: the method uses a solvent one-pot process to synthesize fluralaner, the technological operation of the synthesis process is reduced, the treatment time and the reaction time are shortened, meanwhile, the product yield is improved, and the method is suitable for large-scale production.

The invention relates to a technology for preparing high-dissolution-rate antiparasitic drug fenbendazole and belongs to the field of veterinary preparation. A preparation method of the high-dissolution-rate antiparasitic drug fenbendazole comprises the following steps: adding a fenbendazole crude drug in food grade solvent, heating to dissolving fenbendazole, and preparing fenbendazole solution; adding a food grade emulsifying agent in the fenbendazole solution, and stirring, so that the food grade emulsifying agent is uniformly dispersed, and fenbendazole emulsion is obtained; slowly adding the fenbendazole emulsion into a food grade adsorbent, mixing, stirring continuously, and thus the high-dissolution-rate fenbendazole solid pharmaceutical preparation can be prepared. The high-dissolution-rate antiparasitic drug fenbendazole has the advantages that dissolution efficiency of insoluble fenbendazole in a gastrointestinal tract is improved to the utmost extent, and dissolution rate is increased to more than 70% from the original less than 1%.

The invention relates to a veterinary anthelmintic, and particularly relates to a veterinary albendazole/ivermectin dry suspension with using convenience and significant drug effects. The dry suspension is prepared by steps of stirring 0.1-0.2 part of ivermectin and 2-4 parts of sodium carboxymethylcellulose and mixing, adding 2-4 parts of a flavoring agent after the powder is mixed uniformly, and mixing uniformly again; stirring 5-15 parts of albendazole and 10-20 parts of sodium chloride and mixing, adding 5-10 parts of sodium citrate after the powder is mixed uniformly, and mixing uniformly again; adding the former into the latter through an equivalent increment method, and stirring uniformly; adding the balance of other auxiliary material, and further uniformly stirring and mixing; and subpackaging to obtain the finished product. The other auxiliary material is soluble starch or microcrystalline cellulose. The dry suspension can be proportionally added in an automatic drinker directly for use, thus facilitating all-round dosing in a large-size livestock farm. The dry suspension avoids the toxic and side effect caused by non-uniform feed mixing, and is more convenient to use. The drug effect is remarkably enhanced, and the cost is obviously lowered in comparison with the prior art. The dry suspension has a wide application prospect.

The invention belongs to veterinary insect repellent medicine and preparing method technical field, and in particular relates to a decoquinate and lincomycin hydrochloride-containing pet insect repellent tablet and a preparation method thereof, the pet insect repellent tablet preparation comprises (a) decoquinate and lincomycin hydrochloride as raw material medicines, (b) an adhesive, (c) a wetting agent, (d) a disintegrating agent, (e) a filler and (f) a sweetener. The decoquinate and lincomycin hydrochloride-containing pet insect repellent tablet is prepared by a wet process, and is a white-like tablet in character. The decoquinate and lincomycin hydrochloride-containing pet insect repellent tablet is good in stability and good in palatability, and can be used a veterinary oral preparation.

The invention discloses a clip type automatic timing dog vermifuge feeding device, comprising a dosage pipe, a dosage door, a driving assembly, a clip type drug box, and a control device. The driving assembly comprises a push plate, a reciprocating type linear driver, and a connecting rod used to connect the push plate and the reciprocating type linear driver. One part of the connecting rod and the push plate are in the dosage pipe. The control device comprises a single-chip microcomputer with a timer. The control device is out of the dosage pipe. The dosage door is on the dosage pipe. The upper opening of the clip type drug box is on one side of the dosage pipe. The device overcomes troubles that deworming on dogs at regular time in each month by manpower can hardly be executed normatively or can hardly be executed by natural reasons, and occupation costs of an anthelmintic process on time, material sources, and manpower are reduced.

The invention relates to a Mongolian medicine for treating amenorrhea, a preparation technology thereof and an application of the Mongolian medicine as an anthelmintic. T Mongolian medicine for treating amenorrhea is prepared from, by weight, 45-55 parts of Radix Inulae, 20-30 parts of sappan wood, 0.03-0.07 part of 1,8-cineole and 30-40 parts of Areca catechu. The preparation technology comprisesthe following steps: mixing all above raw drugs, and crushing the mixed raw drugs to form fine powder. The Mongolian medicine can be clinically applied as the orally administrated anthelmintic. The Mongolian medicine can treat the amenorrhea induced by various reasons, and has the advantages of remarkable effects, easily available raw materials and no toxic or side effects; and the preparation technology is simple, breaks traditional Mongolian medicine preparation technologies only adopting the crushing of the raw drugs, forms a modern Mongolian medicine preparation technology suitable for drugs, and has the advantages of raw material saving, drug effect improvement, convenience in promotion and use, and establishing of a way for the Mongolian medicine treatment of the amenorrhea.

The invention discloses a preparation method of an isoxazoline anthelmintic fluralaner. The preparation method comprises the following steps: by taking ethyl 4-[3-(3,5-dichlorophenyl)-4,4,4-trifluorobutyl-2-enoyl]-2-methyl-benzoate and hydroxylamine hydrochloride as initial raw materials, carrying out cyclization reaction under the catalysis of a phase transfer catalyst and an acid-binding agent, then carrying out alkaline hydrolysis reaction, and finally carrying out condensation reaction with 2-amino-N-(2,2,2-trifluoroethyl)acetamide to obtain the fluralaner. The synthetic route is short, the reaction condition is mild, the operation is simple and convenient, the conversion rate is high, the method is suitable for industrial production, the purity can reach 99.5% or above, and the single impurity content is less than 0.1%.

The invention relates to the technical field of communication equipment, and discloses an angle-adjustable anti-interference antenna base, which comprises a fixed bottom plate, a third gear is engagedwith a second gear, the other end of a fixed frame is fixedly connected with an antenna flitch, the surface of the antenna flitch is provided with a medicament nozzle, and the upper surface of the fixed bottom plate is provided with a sliding rail. The sliding rail is movably connected with a rack plate, the two ends of the rack plate are movably connected with connecting rods, the other ends ofthe connecting rods are movably connected with medicine storage bags, a servo motor drives a second gear to rotate and drives a third gear to rotate, the elevation angle of the antenna is continuouslychanged at the moment, the servo motor is turned off when the angle is reached, and the purpose of adjusting the elevation angle of the antenna is achieved. The second gear drives the rack plate to move horizontally to extrude the drug storage bag, and the insect repellent is sprayed to the surface of the antenna from the drug nozzle, thereby achieving the effects of repelling insects and blowingoff dust on the surface of the antenna, and achieving the purpose of preventing an antenna signal from being affected.

The invention relates to a traditional Chinese medicine parasite-expelling composition and a preparation method thereof, and relates to the technical field of insect repellents. The traditional Chinese medicine parasite-expelling composition is prepared from the following raw materials in parts by weight: 25 to 35 parts of wormwood, 15 to 25 parts of rosemary, 12 to 20 parts of honeysuckles, 10 to20 parts of platycodon grandiflorum, 5 to 10 parts of chrysanthemums and 8 parts of a bacteriostatic agent, wherein the bacteriostatic agent is prepared from mint, wrinkled gianthyssop herb, lilac and sage according to a weight ratio of (1-2):(1-2):(3-4):(1-2), has the advantages of good mosquito repelling effect and high detumescence speed, also has bacteriostatic and antibacterial effects, cancontinuously resist and inhibit bacteria of the traditional Chinese medicine parasite-expelling composition, and is beneficial to prolonging the validity period of the traditional Chinese medicine parasite-expelling composition. In addition, the invention further discloses a preparation method of the traditional Chinese medicine parasite-expelling composition, the method comprises the steps of smashing, soaking, decocting, concentrating and mixing, the leaching efficiency and leaching rate of all the raw materials of the traditional Chinese medicine parasite-expelling composition can be improved, and the preparation method has the advantages of being simple in process and high in production efficiency.

The invention belongs to the technical field of anti-parasitic drugs, and particularly relates to application of a composition in preparation of veterinary anthelmintic drugs, a veterinary anthelmintic transdermal solution and a preparation method thereof. The transdermal solution takes isopropanol as a solvent and comprises the following components in percentage by volume: 40%-70% of glycerol methylal, 5%-15% of isopropyl myristate, a fat-soluble antioxidant, ivermectin and praziquantel, wherein the ratio of the mass of the fat-soluble antioxidant to the volume of the transdermal solution is(0.02-0.08) g: 100mL; the ratio of the mass of the ivermectin to the volume of the transdermal solution is (0.3-1) g: 100mL; and the ratio of the mass of the praziquantel to the volume of the transdermal solution is (5-15) g: 100mL. The veterinary anti-parasite composition has a wide anti-parasite spectrum, and the transdermal solution not only improves the anti-parasite spectrum, but also is small in side effect and convenient to use, and reduces the labor cost of drug delivery.

The invention provides a compound long-acting microsphere anthelmintic containing ivermectin, albendazol sulfoxide and praziquantel. The invention provides a process for coating a polylactic acid microsphere with ivermectin, albendazol sulfoxide and praziquantel, wherein an organic solvent containing ivermectin, albendazol sulfoxide and praziquantel is dispersed with a polylactic acid aqueous solution at high speed, and the mixture is centrifugally separated and dried in vacuum to obtain a stable drug-containing microsphere after the organic solvent is volatized. The process is simple in equipment and environmental friendly in production process, and has great economical and social benefits.

The invention relates to the field of larva activity detection, and particularly discloses a nematode larva activity detection method and application. The nematode larva activity detection method comprises the following steps: (1) dyeing nematode larvae by using methylene blue as a coloring agent; and (2) 5-7 minutes later, determining the activity of the nematode larvae according to the colors ofthe nematode larvae: when the nematode larvae are blue or light blue, it is determined that the nematode larvae are dead or low-activity larvae, and when the nematode larvae are in an undyed state, it is determined that the nematode larvae are high-activity larvae. According to the method, MB is used as a coloring agent to visually identify the activity condition of the digestive tract nematode larvae according to the dyeing depth effect, convenience and rapidness are achieved, the cost is low, subjective judgment difference can be effectively avoided, help is provided for researching the pesticide effect, drug resistance and other aspects of anthelmintics, and the method has great significance in selecting sensitive drugs to guide clinical medication and the like.