14 results about "Anthelmintic drug" patented technology

Disclosed in the present invention are a triazine derivative, a preparation method therefor and the use thereof, belonging to the technical field of drug synthesis. Specifically, disclosed in the present invention are a triazine derivative represented by general formula (I), a pharmaceutical composition containing the triazine derivative, and the use thereof in the preparation of an anthelmintic drug for humans or animals. The general structural formula (I) of the triazine derivative is shown as follows. The triazine derivative of the present invention has a significant effect in resisting zoonotic helminths such as nematodes and heartworms, and has a broad application prospect.

The utility model relates to the technical field of anthelmintics, and discloses a feed anthelmintics blending and mixing device which comprises a mixing barrel, a feeding pipe and a discharging pipe are arranged on one side of the upper end of the mixing barrel and the middle of the lower end of the mixing barrel respectively, a barrel cover is detachably arranged at the upper end of the mixing barrel, a pesticide feeding pipe is arranged above the barrel cover, and a stirring shaft is rotatably connected to the middle of the lower portion of the barrel cover. The stirring shaft is driven by a motor fixedly arranged above the barrel cover, a spiral stirring blade is fixedly arranged on the stirring shaft, a square stirring frame is arranged on the stirring shaft and located on the outer side of the spiral stirring blade, a plurality of stirring blocks are arranged on two side plates of the square stirring frame, and a plurality of barrier strips are arranged on the inner wall of the mixing barrel. The stirring device has the advantages that the stirring effect on feed and anthelmintic is good, the uniformity is high, and the situation that the local drug content is too high is prevented.

The invention provides a bow roundworm infection animal model as well as an establishment method and application thereof, and aims to establish a stable and repeatable bow roundworm infection animal model and explore the application value of the bow roundworm infection animal model. By optimizing the egg separation and culture technology, the development rule of infectious eggs is determined; a quantitative infection strategy is adopted to dynamically monitor worm egg discharge dynamics, clinical symptoms and blood index changes, and the reliability of the model is comprehensively evaluated; the model is further utilized to perform curative effect verification on a commercial anthelmintic drug Blein, and the result shows that the constructed animal model infected by the cat head roundworm can be used for drug effect evaluation.

A plateau railway engineering disturbance key protection plant protection technology is characterized by specifically comprising the following steps that forest land areas needing to be classified are selected, and needed data are obtained; performing field investigation on the key protected plants, and recording specific data; setting water and soil conservation measures; placing a water-soluble graphene plant growth promoter; placing an insect repellent; hanging a signboard; and setting a protection range. According to the invention, the water-soluble graphene plant growth agent, the insect repellent and water and soil conservation measures are combined, so that key protection plants are protected. The method provided by the invention has a remarkable protection effect on key protection plants interfered by engineering in high-altitude areas.

The utility model belongs to the technical field of parasite expelling medicine bag distribution, and particularly relates to a wild animal parasite expelling medicine bag distributor which comprises a supporting frame and a supporting rod, and the supporting rod is fixedly connected to the top of the supporting frame. Through the arrangement of the distribution device, when the stress block moves towards the outer side of the material box to the end in advance, the stress plate does arc-shaped movement downwards under the action of the sleeve and the circular shaft without the support of the material box, so that the insect repellent placed in the moving plate falls to the ground, and when the stress block resets, the material box is not supported by the material box. The stress plate can be reset under the supporting force again, the anthelmintic falling on the ground can be licked and rubbed by the walking wild animals, so that the anthelmintic effect on the wild animals is achieved, and the problem that the anthelmintic placed in the moving plate cannot fall on the ground and cannot be damaged is solved. The insect repellent medicine bag cannot fall on the ground to be licked and rubbed by the walking wild animals, and the insect repellent effect on the wild animals cannot be achieved.

The invention provides a green and efficient preparation method of an anthelmintic albendazole sulfoxide, which is characterized in that water is used as a green oxygen source, an anodic oxidation reaction is driven by electric energy at room temperature, albendazole sulfoxide is synthesized with high selectivity, and sulfone by-products generated by excessive oxidation are effectively avoided. According to the method, albendazole, cheap electrolyte sodium bromide, dimethyl sulfoxide and water are mixed into homogeneous reaction liquid, inert gas protection is not needed, and the homogeneous reaction liquid is introduced into an electrochemical microchannel continuous reactor to achieve oxidation. Compared with a traditional hydrogen peroxide oxidation method and a low-temperature chemical oxidation method, the method does not need to use a stoichiometric oxidizing agent, is mild in reaction condition, effectively avoids related safety and environmental risks, meets the requirements of green and sustainable development, and has a good industrial application prospect.

The utility model discloses a body surface insect expelling necklace for animal husbandry, which is mainly applied to the technical field of animal husbandry articles, and comprises a necklace, a medicine box support, a medicine box base, a medicine box, an upper cover, a medicine adding channel, a rubber plug and a volatilization core, the middle part of the necklace is provided with a medicine box support groove, and the medicine box support is clamped in the medicine box support groove; a plurality of medicine box bases are fixedly connected to the medicine box support, medicine boxes are detachably connected into the medicine box bases, upper covers are detachably connected to the tops of the medicine boxes, platforms are arranged in the medicine boxes, through holes are formed in the centers of the platforms, volatilization cores are placed on the platforms, protrusions are arranged in the centers of the volatilization cores, and the protrusions extend to the bottoms of the medicine boxes. The body surface insect expelling necklace for livestock raising is scientific and reasonable in structural design, convenient and fast in medicine adding operation, high in efficiency, long in insect expelling time, safe and reliable, insect expelling medicine does not make direct contact with the body surface of livestock, medicine is used only through natural volatilization, and the insect expelling medicine can be prevented from harming the health of the livestock and being accumulated in the livestock.

This invention provides a method for preparing and applying a long-acting anthelmintic compound microcapsule. The long-acting anthelmintic compound microcapsule is composed of a component containing an anthelmintic drug, white petrolatum, and pollen microcapsules; the anthelmintic drug content is 10-30 wt% of the total weight. Based on a unique supercritical carbon dioxide mixing process, this invention achieves efficient loading of the anthelmintic agent into the pollen microcapsules under mild conditions. This process further utilizes the porous nature of the microcapsules to achieve sustained release of the anthelmintic agent, thereby effectively prolonging the duration of action. Furthermore, thanks to its micron-sized structure, the microcapsule ensures that the anthelmintic component acts only on the body surface, preventing it from penetrating the skin, thus significantly improving the safety of use.

The utility model discloses a veterinary drug grinding device which comprises a smashing box, three annularly-arranged supporting plates are fixedly installed on the upper surface of the smashing box, a mounting base is fixedly installed at the ends, close to each other, of the three supporting plates, a first bearing is fixedly embedded in the upper surface of the mounting base, and a second bearing is fixedly embedded in the upper surface of the mounting base. A rotating shaft is fixedly installed on the inner ring of the first bearing, a top plate is fixedly installed at the bottom end of the rotating shaft, and two vertical plates are fixedly installed on the bottom face of the top plate. According to the device, the upper surface of a top plate and the bottom end of a rotating shaft are fixedly installed, so that when the rotating shaft rotates, the top plate and two vertical plates below the top plate can be driven to rotate, and the two ends of a grinding roller are fixedly installed with inner rings of first bearings embedded in the right side faces of the two vertical plates correspondingly; and the two vertical plates can drive the grinding roller to roll above the filter plate when rotating, so that the grinding roller can grind the vermifuge into powder, and the device can effectively reduce the time cost of farmers.

The invention discloses a method for intervening growth of echinococcus multilocularis based on diapause pheromone Ascr # 18 and application, and belongs to the technical field of prevention and control of zoonosis parasitic diseases. According to the invention, the Ascr # 18 is identified in the echinococcus multilocularis through liquid chromatography-mass spectrometry (LC-MS) for the first time, and it is verified that the Ascr # 18 can be combined with a downstream G-protein coupled receptor (GPCR) in a high-affinity manner, and a signal channel is activated. After the Ascr # 18 is treated, the expression level of development key genes daf-9 and daf-12 in the protoscolex of the echinococcus multilocularis can be remarkably reduced, and the movement activity of the development key genes daf-9 and daf-12 is inhibited, so that the development process and infection ability of parasites are blocked. The invention provides a novel biological prevention and control strategy which does not depend on traditional chemical anthelmintic drugs, is high in targeting, high in safety, environment-friendly and controllable, is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and an application reference for prevention and control of other tapeworm and larva parasitic diseases.

The agricultural intelligent cultivator capable of improving the soil environment comprises a cultivator body, the rear end of the cultivator body is fixedly connected with an installation frame, the left end and the right end of the installation frame are both fixedly connected with supporting frames, and the upper ends of the two supporting frames are both rotationally connected with rotating bases through hinged shafts; the left end and the right end of the mounting frame are each provided with a deinsectization assembly, and one deinsectization assembly comprises an electric push rod, a rotating frame, a swing frame, a connecting strip, a plurality of flame guns and an air pipe. The foldable flame gun solves the problem that insects in farmland soil have drug resistance and further influence growth of crops, is reasonable in structure and good in practicability, and can effectively solve the problem of drug resistance of the insects in the farmland soil by killing the insects in the soil of the crops in batches through the foldable flame gun.

The utility model provides a separation device for an insect repellent intermediate, which comprises a liquid storage tank, the inner wall of the liquid storage tank is fixedly connected with a filter cartridge, the inner wall of the filter cartridge is fixedly connected with a first fixed pressure plate, and the inner wall of the filter cartridge is fixedly connected with a second fixed pressure plate below the first fixed pressure plate. Compared with the prior art, the filter has the following beneficial effects that the two movable pressing plates are driven to synchronously rotate through the motor and the swing shaft, and in the process, the first fixed pressing plate and the second fixed pressing plate are matched to continuously extrude a material in the filter cartridge, and a liquid-phase material falls into the liquid storage tank from the filter cartridge; after solid-liquid separation is completed, the electric push rod is matched to enable the sealing cover to be far away from the discharging opening, the solid-phase material falls into the discharging groove from the discharging opening, finally, the liquid outlet pipe and the discharging pipe are opened, the solid-phase material and the liquid-phase material which are well separated can be obtained, and therefore separation of the intermediate is achieved; and the sealing performance between the sealing cover and the discharging opening is effectively improved through the compression spring.

The present application relates to a kind of isoxazoline anthelmintic preparation preparation method, comprising the following steps: S1. the raw material drug is weighed with solvent component;Wherein, solvent component includes antioxidant, cosolvent, flavouring agent and surfactant;S2. first, add surfactant, while stirring, add cosolvent, then cooling;S3. flavouring agent, antioxidant, raw material drug are sequentially added, and stirring is dissolved;S4. filter, fill and pack, and the preparation obtained in the application is orally administered, can be mutually soluble with water in any ratio, has good stability, high safety, good curative effect, greatly expands the clinical application range of isoxazoline anthelmintic preparation, and preparation method is simple, suitable for mass production.

The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. daf-9 With daf-12 The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application discloses a method for interfering with the growth of multilocular echinococcosis based on diapause pheromone Ascr#18 and application thereof, and belongs to the technical field of prevention and control of parasitic zoonosis. The application provides a novel biological prevention and control strategy which is independent of traditional chemical deworming drugs, has high targeting, high safety, is environment-friendly and controllable, and is suitable for comprehensive prevention and control of alveolar echinococcosis, and can also provide a theoretical basis and application reference for prevention and control of other cestode larva parasitic diseases.