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Application of composition in preparation of veterinary anthelmintic drugs, veterinary anthelmintic transdermal solution and preparation method thereof

A technology of a composition and a solution, which is applied in the field of veterinary anthelmintic transdermal solution and its preparation, can solve the problems of increasing the toxicity and side effects of drugs and doses, poor deworming effect of ectoparasites, and increasing labor costs, etc. Action time, no gastrointestinal reaction, and the effect of reducing labor costs

Pending Publication Date: 2020-11-27
吉林吉力生物技术研究有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Praziquantel, in addition to having good anthelmintic activity against trematodes and cysticercosis, can also expose the body surface antigens of the worms, thereby making the worms vulnerable to immune attacks from the host and improving the immune response of the host. Insect repellent effect is poor
[0004] In addition, injections, powders, tablets, and pourings are widely used in the dosage forms of veterinary anthelmintic drugs at present, and the treatment is carried out step by step by means of internal and external administration. Convenient to increase a lot of labor costs

Method used

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  • Application of composition in preparation of veterinary anthelmintic drugs, veterinary anthelmintic transdermal solution and preparation method thereof
  • Application of composition in preparation of veterinary anthelmintic drugs, veterinary anthelmintic transdermal solution and preparation method thereof

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preparation example Construction

[0045]The present invention also provides a preparation method of the veterinary anthelmintic transdermal solution described in the above technical solution, comprising the following steps:

[0046] (1) mixing the isopropanol, glycerol pyruvate, isopropyl myristate, fat-soluble antioxidant, ivermectin and praziquantel to obtain a mixed solution;

[0047] (2) The mixed solution is sterilized and filtered by a microporous membrane to obtain a veterinary anthelmintic transdermal solution.

[0048] In the present invention, the isopropanol, glycerol pyruvate, isopropyl myristate, fat-soluble antioxidant, ivermectin and praziquantel are mixed to obtain a mixed solution. In the present invention, the mixing method preferably includes the following steps:

[0049] (a) isopropanol and ivermectin are mixed and dissolved to obtain the first solution;

[0050] (b) mixing and dissolving glycerin formal and praziquantel to obtain a praziquantel glycerin formal solution; mixing isopropyl ...

Embodiment 1

[0057] A transdermal solution for veterinary insect repellent, using isopropanol as solvent, including 65% glycerin formal, 5% isopropyl myristate, tert-butyl p-hydroxyanisole, ivermectin and praziquantel;

[0058] The ratio of the mass of the tert-butyl-p-hydroxyanisole to the volume of the transdermal solution is 0.05g:100mL;

[0059] The ratio of the quality of the ivermectin to the volume of the transdermal solution is 1g:100mL;

[0060] The ratio of the quality of the praziquantel to the volume of the transdermal solution is 8g:100mL

[0061] Preparation of the transdermal solution:

[0062] (1) Take 15ml of isopropanol and 1g of ivermectin, add isopropanol into the ivermectin and stir until completely dissolved to obtain the first solution;

[0063] (2) Take 65ml glycerin formal, 5ml isopropyl myristate, 0.05g tert-butyl p-hydroxyanisole and 8g praziquantel, add glycerin formal to praziquantel and stir until completely dissolved to obtain Praziquantel glycerin formal...

Embodiment 2

[0067] A veterinary insect repellent transdermal solution, using isopropanol as a solvent, includes 70% glycerin formal, 10% isopropyl myristate, tert-butyl p-hydroxyanisole, ivermectin and praziquantel;

[0068] The ratio of the quality of the tert-butyl-p-hydroxyanisole to the volume of the transdermal solution is 0.08g:100mL;

[0069] The ratio of the quality of the ivermectin to the volume of the transdermal solution is 0.7g:100mL;

[0070] The ratio of the quality of the praziquantel to the volume of the transdermal solution is 5g:100mL

[0071] Preparation of the transdermal solution:

[0072] (1) Take 10ml of isopropanol and 0.7g of ivermectin, add isopropanol into the ivermectin and stir until completely dissolved to obtain the first solution;

[0073] (2) Take 70ml glycerin formal, 10ml isopropyl myristate, 0.08g tert-butyl p-hydroxyanisole and 5g praziquantel, add glycerin formal to praziquantel and stir until completely dissolved to obtain Praziquantel glycerin ...

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Abstract

The invention belongs to the technical field of anti-parasitic drugs, and particularly relates to application of a composition in preparation of veterinary anthelmintic drugs, a veterinary anthelmintic transdermal solution and a preparation method thereof. The transdermal solution takes isopropanol as a solvent and comprises the following components in percentage by volume: 40%-70% of glycerol methylal, 5%-15% of isopropyl myristate, a fat-soluble antioxidant, ivermectin and praziquantel, wherein the ratio of the mass of the fat-soluble antioxidant to the volume of the transdermal solution is(0.02-0.08) g: 100mL; the ratio of the mass of the ivermectin to the volume of the transdermal solution is (0.3-1) g: 100mL; and the ratio of the mass of the praziquantel to the volume of the transdermal solution is (5-15) g: 100mL. The veterinary anti-parasite composition has a wide anti-parasite spectrum, and the transdermal solution not only improves the anti-parasite spectrum, but also is small in side effect and convenient to use, and reduces the labor cost of drug delivery.

Description

technical field [0001] The invention belongs to the technical field of antiparasitic drugs, and in particular relates to the application of a composition in the preparation of veterinary anthelmintic drugs, a veterinary anthelmintic transdermal solution and a preparation method thereof. Background technique [0002] The harm of parasites to animals is mainly through the consumption of nutrients in cattle and sheep, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for animals, resulting in slow growth of cattle and sheep, and a decrease in feed utilization rate. Current veterinary anthelmintic drugs are mainly divided into anthelmintics, anthelmintics and in vitro insecticides. Since animal parasitic diseases are mostly mixed infections, veterinary anthelmintics with high efficiency, broad spectrum, low toxicity and convenient administration should be selected. [0003] At present, veterinary anthelmintics are all prepared according...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4985A61K9/08A61K47/10A61K47/14A61P33/10A61P33/14
CPCA61K9/0014A61K9/08A61K31/4985A61K31/7048A61K47/10A61K47/14A61P33/10A61P33/14A61K2300/00
Inventor 张国军岑岳明陈博王兆哲齐宇蒋依倩
Owner 吉林吉力生物技术研究有限公司
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