Tetrahydropalmatine transdermal patch and preparation method thereof

A technology of tetrahydropalmatate and transdermal patch, which is applied in the directions of sheet delivery, pharmaceutical formulations, and medical preparations with non-active ingredients, etc. Inconvenience and other problems, to avoid first-pass effect, improve bioavailability, and analgesic effect

Active Publication Date: 2010-05-12
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation types are mainly oral preparations and injections. Oral preparations have low bioavailability, short half-life, long-term oral administration, and the first-pass effect of drugs; injections are inconvenient to administer, painful during injection, and have strict quality requirements , Improper use is prone to danger

Method used

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  • Tetrahydropalmatine transdermal patch and preparation method thereof
  • Tetrahydropalmatine transdermal patch and preparation method thereof
  • Tetrahydropalmatine transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Embodiment 1: Tetrahydropalmatine transdermal patch

[0120] Tetrahydropalmatine: 0.5kg

[0121] lauryl nitrogen Ketones: 1kg

[0122] Acrylic pressure sensitive adhesive: 5kg;

[0123] Get 0.5kg of tetrahydropalmatine, add 5kg of acrylic pressure-sensitive adhesive and lauryl nitrogen Ketone 1kg, dissolved and mixed, was prepared into a solution; using the salivation process, the above solution was coated on the backing layer, evaporated to the solvent, and covered with a protective layer after cooling to obtain a tetrahydropalmatine transdermal patch.

Embodiment 2

[0124] Embodiment 2: Tetrahydropalmatine transdermal patch

[0125] Tetrahydropalmatine: 1kg

[0126] Menthol: 0.5kg

[0127] Polyisobutylene pressure sensitive adhesive: 8kg;

[0128] Take 1 kg of tetrahydropalmatine, add 8 kg of polyisobutylene pressure-sensitive adhesive and 0.5 kg of menthol, dissolve and mix, and prepare a solution; use the salivation process to coat the above solution on the backing layer until the solvent is evaporated, and cool the back cover On the protective layer, get tetrahydropalmatine transdermal patch.

Embodiment 3

[0129] Embodiment 3: Tetrahydropalmatine transdermal patch

[0130] Tetrahydropalmatine: 1.5kg

[0131] Propylene glycol: 1.5kg

[0132] Polysiloxane pressure sensitive adhesive: 7kg;

[0133] Take 1.5kg of tetrahydropalmatine, add 7kg of polysiloxane pressure-sensitive adhesive and 1.5kg of propylene glycol, dissolve and mix, and prepare a solution; adopt the salivation process, coat the above solution on the backing layer, evaporate the solvent to dryness, and cool Cover the protective layer to get the tetrahydropalmatine transdermal patch.

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Abstract

The invention discloses a tetrahydropalmatine transdermal patch and a preparation method thereof. The patch comprises a back lining layer, a drug-storage layer and a protective layer, wherein the raw materials of the drug-storage layer comprise tetrahydropalmatine and pressure sensitive adhesive, or a moderate amount of transdermal accelerant and the like is added to finally prepare the tetrahydropalmatine patch. The tetrahydropalmatine patch has the advantages that the patch has convenient use, high bioavailability and lasting action and avoids liver 'first pass effect' and damages on gastrointestinal tract; and the patch reduces drug toxicity and side effects and increases drug bioavailability and therapeutic safety, thereby having outstanding anti-inflammatory and analgesic effects.

Description

technical field [0001] The invention relates to a transdermal patch and a preparation method thereof, in particular to a tetrahydropalmatine transdermal patch and a preparation method thereof. Background technique [0002] Pain is the most common multiple co-symptom in clinical diseases of medical research, and this conundrum is a great challenge for researchers and doctors. Nowadays, the drugs for pain treatment are mainly Western medicines, which are mainly divided into two types: non-steroidal anti-inflammatory analgesics and narcotic analgesics. Among these two types of drugs, although anesthetic drugs have strong analgesic effects, they have large side effects ( Addiction), although non-steroidal anti-inflammatory analgesics do not have such a large side effect of narcotic analgesics, but there are many negative adverse reactions such as gastrointestinal tract. The medical field is also constantly seeking anti-inflammatory analgesics with good analgesic effect and mini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4375A61K47/32A61K47/34A61K47/44A61K47/46A61P29/00
Inventor 刘海龙黄玉兰高虹陈丽娟
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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