535results about How to "Small steric hindrance" patented technology

The invention discloses a denitrification dephosphorization antibacterial composite water treatment material used for water reclamation, belonging to the field of environmental protection. In the invention, zeolite is modified by a method combining high temperature activation and chemical treatment; natural clinoptilolite is treated by a NaCl solution for the first time to improve ammonia nitrogen removal capacity and reaction speed of the zeolite; then the zeolite is treated by lanthanum chloride used as a loading agent, wherein lanthanum is attached to the surface of the zeolite in a form of lanthanum oxide and is electrically absorbed to phosphate radical ions to generate lanthanum phosphate complex for dephosphorization; and finally, by utilizing ion-exchanging property of zeolite particles and loading inorganic antibacterial ion Ag+ inside pore canals of the zeolite by adopting a liquid phase ion-exchange method, silver ions and oxygen molecules generate ROS during bacteriostasis, and enzyme in a respiratory chain is inhibited by generated super-oxidation activators, thereby achieving the purpose of bacteriostasis. The invention takes the natural clinoptilolite as an absorbent, has the advantages of rich raw materials, low price, convenient reclamation, low cost on water treatment, and obvious denitrification dephosphorization antibacterial effect in the water reclamation.

The invention provides a kit for detecting a trypanosoma cruzi antibody and a preparation method of the kit. The kit comprises a component A and a component B, wherein the component A is a chagas antigen which is marked by a tracking marker or coated with a magnetic ball; the component B is a chagas second antibody which is coated with the magnetic ball or marked by the tracking marker; and any one of the component A and the component B is marked by the tracking marker and the other one is coated with the magnetic ball. The invention further provides a method for detecting the chagas antibody. By utilizing the kit provided by the invention, the concentration of chagas in a sample can be accurately and flexibly determined. On the basis, a pre-treatment solution is used for carrying out pre-treatment optimization so that the background interference can be reduced and the detection flexibility is improved. Meanwhile, detection of the full-automatic chemiluminiscence method can be realized with the help of a chemiluminiscence immunoassay analyzer, so that the operation time is shortened and manual operation errors are reduced.

A rubber-based resin with high oil absorptivity is proportionally prepared from rubber, alkylstyrene, cross-linking agent, disperser, co-disperser, free radical polymerization trigger, dispersing medium and solvent through adding dispersing medium, disperser and co-disperser into flask, heating to 30-40 deg.C by oil bath under protection of inertial gas, keeping the temp for 20-30 min, adding others in 4-opening flask, variable-speed stirring, reacting, ageing, filtering, washing and vacuum drying.

The invention discloses a preparation method of carbon quantum dots with a high fluorescence property by using glycine and glucose as precursors. The method comprises using the glycine as a surface passivating agent, the glucose as a carbon source material and a hydro-thermal reaction vessel as a reaction platform, carrying out a high-temperature and high-pressure hydrothermal reaction, and removing residues and water through dialysis and freeze drying to obtain carbon quantum dot powder. The preparation method of the carbon quantum dots has characteristics of simple operation, low cost and easy mass production. The prepared carbon quantum dots have excellent properties of high fluorescence property, photobleaching resistance, adjustable light emission and good biocompatibility, can be successfully applied in live cell fluorescence imaging and flow cytometry analysis, and is broad in application prospect in biomedical fields.

The invention relates to a method for preparing glyceride rich in algal oil n-3 polyunsaturated fatty acid through the enzyme process. The method comprises the following steps: taking microbial algal oil as raw material, carrying out hydrolysis of part or all of algal oil respectively through controlling the hydrolysis rate under the catalysis of lipases to obtain glyceride partially hydrolyzed and free fatty acid; enabling the free fatty acid to enrich n-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) through the urea adduct method to obtain an n-3 polyunsaturated fatty acid condensate; and taking the n-3 polyunsaturated fatty acid condensate and glyceride partially hydrolyzed as substrates, taking immobilized lipases as catalysts, and efficiently synthetizing glyceride rich in algal oil n-3 polyunsaturated fatty acid in an organic phase. The invention adopts a complete biological enzymatic enrichment process, the raw material is clean and safe, the process route is scientific and reasonable, the catalytic activity of enzyme is high, the catalyst can be recycled, the cost is low, the reaction condition is mild, the energy consumption is low, the environment is friendly, and the market prospect is wide.

The invention discloses a preparation method of agarose immune magnetic microspheres and applications thereof, and relates to a preparation method of microspheres and applications thereof, which solves the technical problems that an existing purified monoclonal antibody is complex in process, is low in yield, and is high in cost, and coupling agents are hypertoxic. The preparation method comprises the following steps of: 1. preparing a ferric oleate precurser; 2. preparing a magnetic fluid; 3. preparing an oil phase and a water phase; 4. preparing agarose magnetic microspheres; 5. preparing activated and crosslinked agarose magnetic microspheres; 6. preparing agarose magnetic microspheres joined with spacer arms; and 7. preparing agarose immune magnetic microspheres. The agarose immune magnetic microspheres provided by the invention are used for purifying genetic engineering recombination trastuzumab monoclonal antibodies. The agarose immune magnetic microspheres prepared by the invention are used for the field of separating and purifying the monoclonal antibodies.

The invention discloses a carbon-based solid acid catalyst and a preparation method thereof. The preparation method comprises the following steps: proportionally mixing carbon-containing raw materials and a chlorine-containing organic high-molecular compound, and carbonizing a mixture to obtain a black solid product; cooling and grinding the black solid product, and adding a sulfonating agent to perform sulfonating; performing cooling, filtering, washing and drying to obtain a black granular material, wherein the sulfonic group density of the black granular material is 0.1 to 5mmol / g, the chlorine content of the black granular material is 0.2 to 70mg / g, and the molar ratio of C to H to O is 1:(0.05-1.3):(0.1-1). The black granular material comprises a carbon framework and active sites, wherein aromatic carbon layer sheets which are in bridge bond connection so as to form a basic unit; the active sites are connected to the carbon layer sheets and comprise -Cl, -SO3H, -OH and -COOH. The carbon-based solid acid catalyst prepared by using the method is stable in structure, high in acidity, low in cost, good in catalytic effect, easy to recycle and wide in application prospect.

The invention discloses drug-carrying liposome co-modified by folic acid and TAT peptide and a preparation method thereof. The drug-carrying liposome comprises liposome, a long chain targeted membrane material, a short chain targeted membrane material and a drug. Meanwhile, the invention provides the preparation method of the drug-carrying liposome co-modified by folic acid and TAT peptide. The method comprises the following steps: weighing phospholipid, cholesterol, the long chain targeted membrane material, the short chain targeted membrane material and the drug, dissolving the components in an organic solvent, and then carrying out rotary evaporation at 50 DEG C under reduced pressure to remove the organic solvent so as to obtain a medicated liposome membrane; adding a phosphate buffer solution into the medicated liposome membrane for dissolving, carrying out ultrasonic treatment for 2 minutes, and filtering for 10 times by using a 0.22mu m membrane to obtain double-target drug-carrying liposome. According to the drug-carrying liposome disclosed by the invention, the TAT peptide is connected with specific ligands by means of PEG with different weight-average molecular weights to establish a nanometer carrier modified by double ligands, and the prepared drug-carrying liposome can be used for efficiently conveying the drug in tumor cells.

The micro-amp immunity sensor based on mixed self-assembly film comprises: a silicon substrate, a SiO2 and Si3N4 insulation layer, and the concentric circular gold film electrode, SU-8 photoresist ring sensitive film pond, a ring Pt-film counter electrode / reference electrode, a Su-8 photoresist ring reaction pond, and a bio-molecular sensitive film fixed on the electrode. With nano technology and mixed self-assembly film, this invention has well consistence, correlativity and compatibility with IC, and shows a new path for immunity analysis and detection.

The invention discloses an ester polycarboxylate slump retaining agent and a preparation method thereof. The molecular weight of the ester polycarboxylate slump retaining agent is 20000-150000, and the structural formula thereof is shown in the specification, wherein R1 is H or CH3, R2 is H or COOM, R3 is an alkyl group with 2-4 carbon atoms, and M is H, Na or NH4. The ester polycarboxylate slump retaining agent provided by the invention can be used independently or compounded with an existing polycarboxylate additive for use, and solves the technical difficulties that the existing polycarboxylate additive is poor in slump retaining performance or has workability degradation and water bleeding after being compounded with a slump retaining agent. When being applied to concrete, the ester polycarboxylate slump retaining agent has better workability and is unlikely to bleed water in comparison with an ether polycarboxylate product, thereby well solving the problems that the widely applied ether polycarboxylate product on the market at present easily has workability degradation and water bleeding after being mixed with concrete.

The invention relates to a benzene-cored organic compound and application of the benzene-cored organic compound to OLED (organic light emitting diode) devices. The benzene-cored organic compound is high in glass transition temperature and molecular thermal stability, applicable in HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy level and high in Eg, and through device structural optimization, can effectively improve the photoelectric performance of the OLED devices and prolong the service life of the OLED devices.

The invention discloses a preparation method of a hydrotreatment catalyst composition. According to the method, during preparation of a mixture of NixWyOz composite oxide precursor and Al2O3 precursor, sodium meta aluminate is employed as an aluminium source, and sodium meta aluminate and CO2 gas are added with swing addition during a gelatinizing process; after gelatinization, the mixture, molybdena and organic solvent are beaten, mixed, moulded and dried to obtain the catalyst. Particles prepared by the method are large and uniform to improve physical and chemical properties of the catalyst; the catalyst has characteristics of large pore volume, large specific surface area, reasonable aperture distribution and high effective utilization rate of active metal, etc.; and the method solves a problem of difficulty in forming of bulk phase catalyst. The catalyst prepared by the method of the invention is especially suitable for super-deep desulphurization reaction in production of super-cleaning diesel oil.

The invention discloses an iridium complex containing hole transporting functional group and an electroluminescent device of the iridium complex, which are the functional materials and the device structures having application potentials in many respects of the electroluminescent field such as information display, solid illumination and backlight source, etc. A novel ligand is introduced into the complex, wherein the ligand is based on the C^N=N structure and introduced with strong current carrier transporting groups containing N atom as centre, so that not only is the good performance of the complex itself kept but also the electric property of the material is enhanced. The metal iridium complex containing three same ligands is formed by the complexing reaction between the ligands and the metal iridium. Such materials have the advantages of high luminous quantum efficiency, good thermal stability and improved electric property due to the specificity of the structure. The electroluminescent device based on such materials is excellent in performances and is featured with very high application potentials in the fields such as information display, solid illumination and backlight source, and the like.

The invention relates to an energy-containing fragment with nanometer Al / M<x>O<y> / oxidizing agents.The energy-containing fragment comprises, by weight, 10-30% of nanometer aluminum powder, 30-60% of transition metal oxide (the M<x>O<y>), 10-40% of the oxidizing agents, 1-5% of ferrocene, 1-7% of high explosive and 3-8% of mixed binders.The energy-containing fragment has the advantages that the energy-containing fragment is high in energy density and fire setting capacity, good in safety performance and easy to ignite, immediate reaction can be prevented when the energy-containing fragment is driven by explosive, but violent chemical reaction can be carried out in penetration procedures, extremely high-temperature heat can be released, and high-temperature hot reaction products with flowability can be generated.

The invention discloses a selective-oxidized chitosan and a heterogeneous preparation method thereof. The method is characterized in that according to preparation of the oxidized chitosan, macromolecular chitosan is dissolved in an ionic liquid, the chitosan is precipitated from the ionic liquid by adding absolute ethyl alcohol, and porous chitosan is obtained after the ionic liquid in a precipitation is fully replaced through absolute ethyl alcohol dipping and ultrasonic oscillation; the porous chitosan is moistened and expanded in the ionic liquid to form a semisolid gel with certain viscosity, and then partial or all hydroxyls at C6 position in pyranose rings of the chitosan are selectively oxidized into carboxyls in an ionic liquid medium to obtain the selective-oxidized chitosan with adoption of a concentrated nitric acid-concentrated phosphoric acid-sodium nitrite system. According to the method, operation is simple and convenient, the oxidation reaction rate is high, the oxidation degree of the chitosan is easily controlled, oxidation products are easy to separate, the yield of the products is high, the prepared carboxyl chitosan has good antibacterial activity and water solubility, and the ionic liquid can be recycled for cyclic utilization, which is environmentally friendly.

The invention discloses a preparation method of polypeptide, particularly relates to a synthesis method of Bremelanotide and belongs to the field of drug synthesis. The synthesis method comprises the following steps: two fragments of Bremelanotide are synthesized firstly and comprise a fragment with two amino acids and a fragment with five amino acids, p-hydroxymethylbenzoic acid is used for protecting the right side of a Bremelanotide sequence, namely, a carboxyl functional group of lysine, and the final product Bremelanotide is obtained with a counter-clockwise ring-forming synthetic method. The synthesis method has the advantages of being short in synthesis route, high in yield and low in synthesis difficulty and cost, and adopting cheap and available raw materials, and is suitable for industrial production.

The invention discloses a catalyst composition for reducing the normal-to-isomer ratio of aldehyde products which are obtained through a hydroformylation reaction of olefin. The catalyst composition comprises a solvent, a catalyst active component, a cocatalyst, an assistant A and an assistant B, wherein the catalyst active component is a rhodium salt, the cocatalyst is triphenylphosphine, the assistant A is a phosphine-containing alkyl ligand, and the assistant B is indole structure-containing doped benzene. The catalyst composition is applied to hydroformylation of olefin, the normal-to-isomer ratio in the products can be reduced, and the selectivity and stability of a catalyst under the condition of a low normal-to-isomer ratio of less than 10 can be improved.

The invention discloses a method for preparing aromatic aldehyde from lignocellulose hydrolysis residue by a two-step process. The method comprises the following steps of: based on the lignocellulose hydrolysis residue as a raw material, degrading lignin by two-step reaction in a reaction kettle to produce an aromatic aldehyde compound, wherein the first reaction step is activating the lignin by utilizing strong oxidability of a fenton reagent in a proper pH range, and the second reaction step is catalytically oxidizing the lignin by using a copper sulfate catalyst and filling an oxidative gas under an alkaline condition to degrade to produce the aromatic aldehyde compound. By adopting the two-step reaction of the activation and the catalytic oxidization, the method has the characteristics that the lignin in the hydrolysis residue is efficiently degraded into the aromatic aldehyde compound, and the addition value of the hydrolysis residue used as the industrial waste is improved.

The invention relates to an antineoplastic prodrug with a P-glycoprotein inhibition function. The antineoplastic prodrug is an amphiphilic substance formed by connecting antineoplastic drugs and chitosan-polyethlyene glycols-succinate with the P-glycoprotein inhibition function through a connector in a covalent mode. The connector comprises a sensitive bond and at least two reaction functional groups respectively used for connecting the antineoplastic drugs and the chitosan-polyethlyene glycols-succinate in a covalent mode, wherein the sensitive bond is a chemical bond which is easily broken under a reducing environment or an acid environment in a tumor cell. The antineoplastic prodrug with the P-glycoprotein inhibition function is expected to effectively treat tumors and drug-fast tumors.

The invention discloses a test strip for detecting an anti-cyclic citrullinated peptide antibody by colloidal gold chromatography and a preparation method thereof. The test strip comprises a baseplate (7) and a nitrocellulose membrane (3), a conjugate pad (2), a sample pad (1) and a water-absorbing pad (6), which are sequentially stuck on the baseplate (7) by mutual lap joint. A detection region (4) and a quality control region (5) are arranged on the nitrocellulose membrane, the detection region is used for coating a cyclic citrullinated peptide antigen, the quality control region is used for coating the antibody which is used as a quality control material, and the conjugate pad is used for coating two different colloidal gold labeled antibodies. The test strip introduces the branch cyclic citrullinated peptide and carries out process improvement on pretreatment of the sample pad and the conjugate pad, and the invention provides the anti-cyclic citrullinated peptide antibody test strip with high sensitivity and strong specificity, which can quickly screen positive samples and further play an important role for early auxiliary diagnosis of RA and disease monitoring.

The invention belongs to the technical field of composite reverse osmosis membranes and particularly relates to a preparation method of a modified pollution-resistant hybridized reverse osmosis membrane. According to the preparation method, by introducing a combined inorganic nano-particle of a graphene oxide nano-particle, nano-Ag and nano-SiO2 an dissolving the combined inorganic nano-particle by virtue of a compound organic solvent, the result shows that an inorganic nano-material has relatively good dispersity in a polymer film matrix and further has relatively good consistency between twophases of the inorganic nano-particle and a polymer. A polyamide functional layer is hybridized and is grafted with hydrophilous an NH2-PEG-OH molecular chain through chemical reaction, so that the hydrophily of a membrane is improved, and the prepared composite membrane has relatively excellent antibacterial property, pollution resistance and thermal stability and further has huge prospects in industrial water treatment.

The invention relates to a colloidal gold test strip for testing melamine content. The test strip mainly comprises a supporting plate, a sampling zone, a colloidal mark redissolve zone, a color development zone, a water absorbing pad and the like. By adopting the theory of competition method, melamine in a sample is competed with gold mark melamine envelope antigen MEL-OVA, therefore the melamine in the sample is combined with anti-melamine monoclonal antibody on the test strip so as to be developed, and the corresponding relation of the melamine content in the sample and the color development quantity of the test strips is built, therefore the melamine content can be judged according to the color development quantity of the strips in the color development zone. The colloidal gold test strip has the advantages of high specificity, high sensitivity, fast testing speed, simple operation, convenient portability and the like, and can quick and sensitively judge whether the samples, such as milk, feed, animal product, blood and urine, contains melamine, or whether the melamine content exceeds the standard, thus presenting evaluation and judgment to food security and human body health. The colloidal gold test strip can be suitable to the on-site quick screening of food, feed and the like, and can also be applied to the self-check in the daily life at home and autologous melamine content testing of human.

The invention discloses a thermosetting polyimide with a high glass transition temperature and a high heat resistance, and a preparation method thereof. An alkynyl anhydride compound is introduced into a PI molecular chain, and a crosslinking reaction of an alkynyl functional group is carried out to obtain the thermosetting polyimide having a network crosslinked structure. The polymerization process of a polyimide precursor and separation of an imidization process and a crosslinking process are controlled to make the network crosslinked structure of the polyimide tend to be complete. The thermosetting polyimide in the invention forms the network crosslinked structure, so the glass transition temperature is high, and even a significant glass transition process disappears; the heat resistance is improved; and the CTE is also kept close to that of the glass. The thermosetting polyimide with the high glass transition temperature and the high heat resistance in the invention keeps the performances of a film stable in the high-temperature processing process, meets the requirements of a flexible OLED panel product for a flexible substrate, and ensures the application in the OLED panel.

The invention discloses a glycoprotein N-carbohydrate chain one-step enrichment-derivation processing method based on graphene and an MALDI-TOF-MS analysis method. The chain one-step enrichment-derivation processing method comprises performing enzymatic-hydrolysis release on a glycoprotein N-carbohydrate chain, using graphene and pyrenebutyric hydrazide to performing one-step enrichment and derivation on N-carbohydrate chain, eluting N-carbohydrate chain, performing mass spectrometry, and the like. By utilizing the special pi-pi conjugate interaction of an aromatic compound and graphene and utilizing the specific efficient covalent coupling reaction of an aromatic compound containing a hydrazide or amino functional group and a hemiacetal of the N-carbohydrate chain, one-step enrichment and derivation of N-carbohydrate chain is realized, and efficient derivation of N-carbohydrate chain is finished when specific enrichment is performed. Therefore, the method avoids complicated operation steps, improves sample processing flux and substantially reduces sample loss.

The invention discloses novel polyurethane semi-matte white finish for woodware protection. The finish is prepared by mixing the following components: stearic acid modified alkyd resin, polyketone resin solution, an antifoaming agent, an anti-settling agent, a dispersing agent, white slurry, handfeel wax powder, aerosol extinction powder, 20 percent hydroxyl modified vinyl acetate (VAGH) resin, a leveling agent, an anti-yellowing auxiliary agent, a deodorant and butyl ester. A film prepared from the novel polyurethane semi-matte white finish has the advantages of fullness, moderate hardness, high flexibility, high water resistance, yellowing resistance and environmental protection; and the semi-matte white finish has high comprehensive performance.

The invention relates to a method for preparing alkoxymethyl furfural by catalyzing 5-hydroxymethylfurfural. Etherification reaction is performed on 5-hydroxymethylfurfural (5-HMF) and tert butyl alcohol in the presence of a protic acid catalyst, and the technical key points are as follows: the protic acid catalyst is a functional graphene catalyst; and the functional graphene catalyst takes graphene as a carrier, and an acidic organic functional group with catalytic activity is connected on graphene. A benzene sulfonic acid functional group is chemically grafted to the surface of graphene to prepare the functional graphene catalyst, not only the advantage of the sulfonic acid functional group can be realized, but also the adverse factors of homogeneous catalytic reaction of p-methyl benzene sulfonic acid can be avoided, thereby providing a new chance for catalyzing the etherification reaction of 5-HMF and tert butyl alcohol. The reaction has the advantages of high reaction activity and high product yield, and toluene and other organic solvents do not need to be used for reaction.

The invention discloses a preparation method of a hydrotreating catalyst composition. The method comprises the steps of subjecting a salt mixed solution A in which CO2 is dissolved to react with an alkaline solution B containing aluminium to prepare gel, when reaction is completed, controlling the pH value of pulp in a reaction tank to be 7.0-9.0, preparing a mixture of an NixWyOz composite oxide precursor and an Al2O3 precursor, pulping the mixture and MoO3 to prepare a dry body, and then forming, drying and roasting the dry body to obtain a final catalyst, wherein the salt mixed solution A contains components Ni and W. The method has the beneficial effects that the problem that bulk phase catalysts are difficult to form is solved; the physical and chemical properties of the catalyst are adjusted, and the catalyst has the advantages of larger specific surface area, uniform pore distribution and high effective utilization rate of reactive metals; and the catalyst is especially suitable for the ultra-deep desulfurization reaction for producing ultra-clean diesel.

Provided is a preparation method of rare-earth fluorescent silica nano particle, relating to nano material particles. The preparation method comprises the following steps:: mixing water, oil, surfactant and co-surfactant to spontaneously form anisotropic transparent disperse system with stable thermodynamics, so as to obtain silica nano particle with hydroxyl at the surface thereof; reacting silane reagent with functional group with rare earth ionic complex to obtain rare earth ionic complex precursor; mixing the prepared rare earth ionic complex precursor with tetraethoxy silane, and then adding the mixture into the obtained silica nano particle with hydroxyl at the surface thereof, wherein the rare earth ionic complex is bonded on the surface of the silica nano particle; and adding rare earth ions into a water-in-oil micro-emulsion system to form fluorescent rare earth complex by chelating with the earth ionic complex fixed on the surface of the silica nano particle, sealing the reaction system by acetone, and rinsing to obtain the product rare-earth fluorescent silica nano particles. The operation is simple, the implementation is easy and the fluorescent intensity is higher.

The invention discloses a magnetic bead preparing method and application, and belongs to the technical field of magnetic material preparing. The preparing method comprises the steps that firstly, magnetic nanoparticles with the surface functionalization are prepared, then, at least two magnetic nanoparticles with the surface functionalization are connected through a cross-linking agent, and a magnetic bead with the magnetic content of 70 %-98 % is prepared. The problems that the magnetic content of an existing magnetic bead is low, to achieve fast separation, the size of the magnetic bead is greatly increased, and consequently the suspension stability is reduced are solved. In addition, for the captured component biological reaction, particularly for the immunoreaction, the steric hindrance caused by the small magnetic bead is obviously reduced, the capturing capability and the analyzing and detecting sensitivity are improved, the magnetic bead can be better applied to the biological medicine separation and analysis, and the magnetic bead is particularly suitable for separation of cells, bacteria, viruses, DNA / RNA, protein and the like in biological body fluid or reaction fluid and the clinical biochemistry fast automatic detection based on chemiluminiscence electrochemical luminescence and fluorescence.