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External preparation for skin

A skin external preparation, the general formula technology, applied in the field of skin external preparations, can solve the problems of low water solubility, no moisturizing agent, barrier, etc., and achieves the effect of promoting percutaneous absorption, improving skin roughness improvement effect, and promoting keratin permeability. Effect

Active Publication Date: 2009-06-03
SHISEIDO CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this (poly)ethylene glycol dialkyl ether is an oil-based agent, and as an oil component, it can form a hydrophobic coating, thereby exerting a barrier function and inhibiting the loss of moisture through the skin, but its water solubility is low, and it itself does not Does not function as a humectant

Method used

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  • External preparation for skin
  • External preparation for skin
  • External preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0090] Examples of the present invention are described below.

[0091] In addition, before describing the Example of this invention, the evaluation method is shown below.

[0092] "Test Method Using Conductivity Measurement"

[0093] Using the forearms of 10 panelists, the skin conductivity was measured before application and after 30 minutes, 60 minutes, and 120 minutes after application, and the moisturizing effect was evaluated from the rate of change. It should be noted that the change rate of skin conductivity can be obtained by the following formula (III), and the influence on the water absorption and water retention capacity of the stratum corneum can be studied. If the change rate is small, the water content of the stratum corneum increases and the moisturizing effect can be evaluated.

[0094] Formula (III)

[0095] Conductivity change rate = (conductivity before application) / (conductivity after application)

[0096] The evaluation criteria of the "test by electric...

Synthetic example 1

[0142] Synthesis Example 1 Synthesis Example of Random Polymer

[0143] Pentaerythritol-polyoxypropylene glycol (2 moles)-polyethylene glycol (9 moles) tetramethyl ether

[0144] 34 g of pentaerythritol and 3.1 g of potassium hydroxide as a catalyst were placed in an autoclave, and the air in the autoclave was replaced with dry nitrogen, followed by stirring to completely dissolve the catalyst at 140°C. Next, a mixture of 396 g of ethylene oxide and 116 g of propylene oxide was added dropwise using a dropping device, followed by stirring for 2 hours. Next, 75 g of potassium hydroxide was charged, and after replacing the inside of the system with dry nitrogen, 50 g of dichloromethane was pressurized at a temperature of 80 to 130° C. and reacted for 5 hours. Thereafter, the reaction composition was taken out from the autoclave, neutralized with hydrochloric acid to pH 6 to 7, and treated at 100° C. for 1 hour under reduced pressure at -0.095 MPa (50 mmHg) to remove contained ...

Synthetic example 2

[0146] Synthesis Example 2 Synthesis of Sorbitol Derivatives

[0147] Sorbitol-polyoxypropylene glycol (12 moles)-polyoxyethylene glycol (54 moles) hexamethyl ether

[0148] 182 g of pentaerythritol and 18 g of potassium hydroxide as a catalyst were placed in an autoclave, and the air in the autoclave was replaced with dry nitrogen, followed by stirring to completely dissolve the catalyst at 140°C. Next, a mixture of 2376 g of ethylene oxide and 696 g of propylene oxide was dropped almost completely, followed by stirring for 4 hours. Next, 600 g of potassium hydroxide was charged, and after replacing the inside of the system with dry nitrogen, 700 g of dichloromethane was pressurized at a temperature of 80 to 130° C. and reacted for 5 hours. Thereafter, the reaction composition was taken out from the autoclave, neutralized with hydrochloric acid to pH 6 to 7, and treated at 100° C. for 1 hour under a reduced pressure of -0.088 MPa (gauge pressure) to remove contained water....

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Abstract

The present invention discloses an external preparation for the skin, which is excellent in a moisturizing effect, a skin roughness-ameliorating effect and feeling during use. The external preparation comprises a polyoxyalkylene glycol / polyethylene glycol copolymer alkyl ether derivative represented by the general formula (I): (I) wherein Y represents a residue given by removing hydroxyl groups from a polyhydric alcohol having 3 to 6 hydroxyl groups; k represents the number of hydroxyl groups in the polyhydric alcohol; EO represents an oxyethylene group; AO represents an oxyalkylene group having 3 to 4 carbon atoms; and a and b respectively satisfy the requirements shown by the formulae: 1=a=70 and 1=b=70; the ratio of the amount of the oxyethylene group to the total amount of the oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group is 20 to 100% by mass; the oxyalkylene group having 3 to 4 carbon atoms and the oxyethylene group are added randomly; and R's independently represent a hydrocarbon group having 1 to 4 carbon atoms.

Description

[0001] related application [0002] This application claims the priority of Japanese Patent Application No. 2006-142384 filed on May 23, 2006 and Japanese Patent Application No. 2006-269122 filed on September 29, 2006, and the contents thereof are hereby incorporated. technical field [0003] The present invention relates to skin external preparations, particularly skin external preparations containing polyoxyalkylene glycol-polyethylene glycol copolymer alkyl ether derivatives as active ingredients, for moisturizing, improving skin roughness, and improving use feeling. Background technique [0004] In order to maintain healthy skin, moisture retention is essential, and a large number of external skin preparations for the purpose of moisturizing have been developed. In addition, the feeling of use as an external preparation for the skin is required to be smooth and not sticky. [0005] A lot of research is being done on humectants, and examples of humectants used in various...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/86A61K47/34A61Q1/02A61Q17/04A61Q19/00
CPCA61Q19/00A61K8/90A61K47/34A61P17/16A61K8/84
Inventor 宫原令二樋渡幸三渡边启冈隆史円山圭一横泽庆一
Owner SHISEIDO CO LTD
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