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Nicotine slow-release patch

A sustained-release patch and nicotine technology, applied in the field of nicotine sustained-release patches, can solve problems such as nicotine addiction, achieve the effect of reducing the number of times of use, prolonging the use time, and quick onset

Inactive Publication Date: 2014-09-03
SHANGHAI TOBACCO GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, long-term smoking is likely to lead to nicotine addiction

Method used

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  • Nicotine slow-release patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The nicotine slow-release patch in this embodiment is composed of a backing layer, a cover layer and a layer of ointment containing medicine, and the materials used in each layer are as follows:

[0056] Backing layer: non-woven fabric

[0057] Cover lining: polyester film

[0058] The medicated ointment layer, by weight, consists of the following components (1000 stickers):

[0059]

[0060]

[0061] Preparation:

[0062] (1) Preparation of nicotine micelles:

[0063] Weigh 10g of polyethylene glycol-polylactic acid (PEG3000-PLA2000), add 500ml of dichloromethane and 2g of natural tobacco extract, and stir to completely dissolve the material to form a yellow solution. The solution was transferred to a 5 L dry and clean round bottom flask, and the methylene chloride was removed by rotary evaporation in a water bath at 40°C, so that the natural tobacco extract and polyethylene glycol-polylactic acid formed a yellow film on the inner wall of the flask. Then it ...

Embodiment 2

[0069] The nicotine slow-release patch in this embodiment is composed of a backing layer, a cover layer and a layer of ointment containing medicine, and the materials used in each layer are as follows:

[0070] Backing layer: non-woven fabric

[0071] Cover lining: aluminum foil-polyethylene composite film

[0072] The medicated ointment layer, by weight, consists of the following components (1000 stickers):

[0073]

[0074]

[0075] Preparation:

[0076] (1) Preparation of nicotine micelles:

[0077] Same as Example 1

[0078] (2) Preparation of medicated ointment:

[0079] Weigh gelatin, sodium polyacrylate, and polyvinyl alcohol according to the prescription amount, add 400 grams of water to make swelling, stir and mix evenly, and adjust the pH to about 8.0; mix glycerin and zinc oxide evenly, add to the above swelling solution, stir and mix evenly Add the mixture of propylene glycol, azone, menthol, and nicotine micelles to obtain a medicated ointment.

[008...

Embodiment 3

[0083] The nicotine slow-release patch in this embodiment is composed of a backing layer, a cover layer and a layer of ointment containing medicine, and the materials used in each layer are as follows:

[0084] Backing layer: non-woven fabric

[0085] Lid lining: Polyethylene film

[0086] The medicated ointment layer, by weight, consists of the following components (1000 stickers):

[0087]

[0088] Preparation:

[0089] (1) Preparation of nicotine micelles:

[0090] Same as Example 1

[0091] (2) Preparation of medicated ointment:

[0092] Weigh sodium polyacrylate, carbomer 934p and add 400 grams of distilled water to make swelling according to the prescription, add aluminum trichloride, stir and mix evenly and adjust the pH to 8.0, then add mixed glycerin and kaolin, stir and mix; then A mixed solution of propylene glycol, menthol and nicotine micelles is added; finally, citric acid is added, stirred and mixed evenly to obtain a medicated ointment.

[0093] (3) P...

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Abstract

The invention relates to a slow-release patch used for external application and prepared from natural tobacco extracts (nicotine as the main component). The slow-release patch is prepared from the natural tobacco extracts and proper auxiliary materials and is used for achieving the aim of slowly releasing nicotine according to a particle slow-release principle. The nicotine slow-release patch provided by the invention comprises a back lining layer, a medicine-contained paste body and a cover lining layer, wherein the medicine-contained paste body is prepared from auxiliary materials such as nicotine micelle, an adhesive, a filling agent, a transdermal enhancer, a humectant and the like according to a certain ratio; each patch contains 20-40mg of nicotine. The nicotine slow-release patch has the characteristics of slow release, rapidness in taking effects, good moisture retention and air permeability, comfort in use and the like.

Description

technical field [0001] The invention relates to an external dosage form of a natural tobacco extract with the effect of substituting tobacco, in particular to a nicotine slow-release patch. Background technique [0002] The main component of natural tobacco extract is nicotine, commonly known as nicotine, which is an alkaloid present in plants of the family Solanaceae (Solanum). The chemical name of nicotine is: N-methyl-2[α(β,γ)]-pyridyltetrahydropyrrole-1-methyl 3-(3-azaphenyl)azolane, English The chemical name is (S)-3-(1-Methyl-2-pyrroli-dinyl)pyridine. More than 99% of nicotine in natural tobacco leaves is S-(-)-nicotine, the structural formula is as follows figure 1 shown. Its formula C 10 h 14 N 2 , molecular weight 162.23g / mol, melting point -79 ℃, oily liquid substance, soluble in water, ethanol, chloroform, ether, oil, nicotine can penetrate into the skin. In the process of smoking cigarettes, most of the nicotine is inhaled into the lungs through the mouth,...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/465A61P25/34
Inventor 沙云菲张乾李淼沈轶
Owner SHANGHAI TOBACCO GRP CO LTD
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