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Hydrogel patch for skin care and preparation method thereof

A technology for skin care and hydrogel stickers, which is applied in the directions of skin care preparations, cosmetic preparations, medical preparations with inactive ingredients, etc. problems, to achieve the effect of reducing the water separation rate, improving the water separation phenomenon, and promoting percutaneous absorption

Active Publication Date: 2020-12-25
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This performance will not only be manifested when used on the skin, but also will be manifested as the temperature rises during product storage and transportation, which will inevitably cause the loss of moisture and nutrients
Moreover, the resulting hydrogel has strong fluidity, is not easy to cast into a certain shape, cannot be made into different shapes and sizes of sticking care products for different parts of the body, and lacks toughness and strength

Method used

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  • Hydrogel patch for skin care and preparation method thereof
  • Hydrogel patch for skin care and preparation method thereof
  • Hydrogel patch for skin care and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of cross-linked sodium hyaluronate: Accurately take 5 μL of 1,4-butanediol diglycidyl ether and add it to 100 mL of sodium chloride solution (50 mg / mL). After mixing, weigh 1 g of sodium hyaluronate (molecular weight 1000 Da ) was dissolved in the above solution, and after the sodium hyaluronate was fully dissolved, 186ml of ethanol was gradually added until the sodium hyaluronate precipitated a white precipitate. After the whole reaction system showed a solid-liquid suspension system, it was stirred and reacted at 30° C. for 6 hours. Then let stand and discard the supernatant. Finally, wash and dehydrate with ethanol for 3 times, suction filter and discard the filtrate, put the wet powder into a vacuum drying oven at 25°C and dry to prepare cross-linked sodium hyaluronate.

Embodiment 2

[0052] Preparation of cross-linked sodium hyaluronate: 1 wt% aqueous solution of sodium hyaluronate (1 g, molecular weight: 2.8 million Da) was configured in a 100 mL beaker, and then stirred at room temperature for 24 hours to completely dissolve the sodium hyaluronate. Polyvinyl alcohol grafted styryl pyridinium salt (PVA-SbQ) was used as macromolecular photocrosslinking agent. Add the two substances into a beaker wrapped with tin foil according to the ratio of m (sodium hyaluronate): m (PVA-SbQ) = 2: 1, stir for 30 minutes to mix the two evenly, and then use a 3000 rpm Centrifuge at a rotating speed for 5 minutes, and directly cross-link with ultraviolet light to form a hyaluronic acid gel, and the light time is 50-500 s. The obtained hyaluronic acid gel was dialyzed with deionized water for 3 days, and the water was changed every 5 hours; the liquid nitrogen was directly frozen and then freeze-dried to obtain a dry hyaluronic acid gel, which was dried in a vacuum drying ov...

Embodiment 3

[0054] Preparation of cross-linked sodium acetylated hyaluronate: Dissolve 1 g of sterile dry powder of sodium acetylated hyaluronate (molecular weight: 50,000 Da) in 50 mL of NMP, add TEA to adjust the solution to pH=10, then add 0.03 g of CMPI and Reaction at 0°C for 2h. After completion of the reaction, wash with 40 times of volume of normal saline, then precipitate with 40 times of volume of acetone, filter, acetone / water mixed solvent (V 丙酮 / V 水 =5 / 1) washing, vacuum drying at -0.1MPa, 40°C for 8h to obtain cross-linked acetylated sodium hyaluronate.

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Abstract

The invention discloses a hydrogel patch for skin care and a preparation method of the hydrogel patch. A hyaluronic acid substance serves as a main hydrogel matrix to be compounded with a small amountof gel polymers, so that the toughness and the strength of the hydrogel patch are improved. Meanwhile, the hydrogel patch is high in water locking property and low in drainage rate, has the effects of preserving moisture for a long time and promoting percutaneous absorption of active ingredients or medicines, and can be used for skin beauty care, skin trauma and ulcer care and application care ofsoft tissue sprain. Different shapes can be formed by pouring according to different use parts, including the whole face, the nose part, the eyes, the lip, the neck and the body parts such as the abdomen, the hip and the four limbs.

Description

technical field [0001] The present invention relates to a hydrogel patch, in particular to a non-cross-linked hyaluronic acid material as the base, which can be added with various skin conditioning agents and drugs according to the application, and is suitable for skin beauty care, skin wounds and ulcers. Hydrogel patch for nursing care, sticking care for soft tissue sprains, etc. Background technique [0002] Hydrogel is theoretically a compound system with a three-dimensional network structure that can swell but not dissolve in water, and can maintain certain mechanical properties, have sufficient stability in water, and maintain a certain solid shape. Since the hydrogel mask does not require mask carriers such as non-woven fabrics, it has good biocompatibility and reduces the incidence of skin irritation and allergic reactions. The hydrogel has a large water content, and because the spatial grid structure of the hydrogel material can control the volatilization of water t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/36A61K47/10A61K8/02A61K8/73A61K8/34A61Q19/00
CPCA61K9/7023A61K47/36A61K47/10A61K8/0208A61K8/735A61K8/345A61Q19/00
Inventor 黄思玲董建军阚洪玲朱环宇
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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