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Transdermal absorption promoter, and external skin formulation thereof

An absorption enhancer, the technology of mentholoxy, applied in the field of external skin preparations and transdermal absorption enhancers, can solve the problem of low pharmacological active ingredients, achieve excellent safety and usability, and enhance the effect of percutaneous absorption

Inactive Publication Date: 2013-02-20
TAKASAGO INTERNATIONAL CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a disadvantage of transdermal administration of drugs is that the pharmacologically active ingredients of the drug are absorbed at extremely low levels compared to oral administration or injection methods

Method used

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  • Transdermal absorption promoter, and external skin formulation thereof
  • Transdermal absorption promoter, and external skin formulation thereof
  • Transdermal absorption promoter, and external skin formulation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Example 1: Lotion

[0122]

[0123] The above ingredients were mixed together under stirring to give an arbutin-containing lotion.

Embodiment 2

[0125]

[0126]

[0127] The above ingredients are mixed together under stirring to give a resycin-containing cream.

Embodiment 3

[0128] Embodiment 3: Ointment

[0129]

[0130] The above ingredients are mixed together under stirring to give a paroxetine-containing ointment.

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Abstract

The present invention provides a substance which promotes the transdermal absorption of a pharmacologically active component while little irritating the skin. The present invention relates to a transdermal absorption promoter which comprises, as the active component, at least one member selected from among isopulegol, 2-(menthoxy)ethanol and 2-methyl-3-(menthoxy)propane-1,2-diol; and an external skin formulation which comprises a pharmacologically active component such as a psychotropic component, an anti-inflammatory component, an analgesic component, an antipyretic component, a whitening component or a hair growth-promoting component, together with the aforesaid transdermal absorption promoter.

Description

technical field [0001] The present invention relates to a transdermal absorption enhancer for transdermal administration of a pharmacologically active component and an external skin preparation comprising the transdermal absorption enhancer. More specifically, it relates to transdermal absorption enhancers and external skin preparations, both of which are excellent in transdermal absorbability and safety, capable of rapidly delivering desired pharmacologically active ingredients to target sites or via the circulatory system It spreads throughout the body and is thus effective in treating various ailments. Background technique [0002] In recent years, as a method of administering drugs, a transdermal therapeutic system (TTS) by which a desired drug is delivered to the whole body through the skin so that the drug can exert its therapeutic effect over a long period of time has been developed Effect. For example, nitroglycerin and isosorbide mononitrate for treating angina pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/08A61K47/10
CPCA61K9/7084A61K9/7023A61Q19/00A61K31/08A61K31/075A61K31/045A61K47/10A61K9/0014A61K9/06A61K9/7007A61K8/34A61K8/345A61K47/08A61K9/70
Inventor 石田贤哉小幡誉子高山幸三
Owner TAKASAGO INTERNATIONAL CORPORATION
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