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Traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition with antibacterial, anti-inflammatory, hemostatic and analgesic effects and its preparation field, can solve traumatic bleeding without hemostasis and healing promotion, wound irritation, inconvenient coating, etc. problems, to achieve the effect of improving encapsulation efficiency, long-term antibacterial and anti-inflammatory, and prolonging residence time

Inactive Publication Date: 2020-04-14
江西杏林白马药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of drugs for hemostasis in the market. Many traditional Chinese medicines for hemostasis, such as bruise capsules and bruise tablets, are effective in promoting blood circulation and dissipating blood stasis, reducing swelling and pain, and have no hemostatic or healing effect on traumatic bleeding.
Most of the hemostatic drugs of other Western medicines have antibacterial and anti-inflammatory effects. Although they can stop bleeding and promote wound healing, they have problems such as greater irritation to the wound, inconvenient coating, and easy scars after wound healing. In the more obvious parts, the existence of scars brings various inconveniences to the work and life of patients

Method used

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  • Traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and preparation method thereof
  • Traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and preparation method thereof
  • Traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A traditional Chinese medicine composition with antibacterial, anti-inflammatory, hemostatic and analgesic effects, consisting of the following components by weight: 3 parts of monkey earring extract, 3 parts of Duyiwei extract, 9 parts of polylactic acid-glycolic acid copolymer PLGA, vitamin E 4 parts of polyethylene glycol succinate TPGS, 8 parts of poloxamer, 10 parts of carbomer, 1 part of collagen tripeptide, 1 part of oat β-glucan, 1 part of propylene glycol.

[0031] The preparation method of Chinese medicine composition, comprises the steps:

[0032] 1) Preparation of the original medicinal material extract

[0033] Take 1kg of monkey earrings, crush them, pass through a 150-mesh sieve, and carry out subcritical extraction with ethyl acetate as a solvent. The ratio of liquid to solid is 1g:2mL. Concentrate and remove ethyl acetate to obtain monkey earring extract;

[0034] Take 1 kg of Duyiwei, crush it, pass it through a 150-mesh sieve, and carry out subcriti...

Embodiment 2

[0051] 1. Antibacterial effect

[0052] Drug control group: take the monkey earring extract and the unique extract, add purified water to prepare a 0.2% solution containing the monkey earring extract and the unique extract respectively.

[0053] Precisely draw 300 μL of the test bacteria solution of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, inhale it into a sterile petri dish, and pour 10mL to 16mL of nutrient broth agar medium, shake it constantly to make the bacteria solution Evenly, after the culture medium is cooled and solidified, holes are punched equidistantly on the Petri dish and marked. Add 100 μL of the samples of the control group and the above-mentioned test group, shake and mix them evenly. After drying, turn the plate upside down and place it in an aerobic constant temperature incubator at 37°C. After 24 hours, observe the results, measure the size of the inhibition zone, measure 3 times, and take the average value. T...

Embodiment 3

[0061] Animal Pharmacodynamics Experiment

[0062] 1. Anti-inflammatory effect

[0063] 1) Effect on capillary permeability of mice

[0064] Take 50 qualified mice, half male and half female, weighing 18-22 g, and randomly divide them into 5 groups as follows:

[0065] Blank control group: the same volume of normal saline, the application area is 2cm 2 ;

[0066] Positive drug control group: compound dexamethasone gel 0.15g / kg, application area 2cm 2 ;

[0067] Chinese medicine composition nano gel low dose group: 0.15g / kg, coating area 1cm 2 ;

[0068] Chinese medicine composition nano gel medium dose group: 0.20g / kg, coating area 2cm 2 ;

[0069] Chinese medicine composition nano gel high dose group: 0.25g / kg, coating area 4cm 2 ;

[0070] At the same position on the left side of the back spine of mice in each group, depilation treatment was carried out according to the skin area of ​​different dosage groups, evenly smeared on each dosage group, fixed with medical ...

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Abstract

The invention discloses a traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and a preparation method thereof. According to the method, apithecellobium clypearia extract and a lamiophlomis rotata extract are used as raw materials; poly(lactic-co-glycolic acid) PLGA, vitamin E polyethylene glycol succinate TPGS and poloxamer are used as a drug-loaded matrix. The preparation method comprises the following steps: mixing raw medicinal materials with the drug-loaded matrix to form an oil phase and an oil-in-water phase, performing probe ultrasonic emulsification to obtain a nano-suspension, and adding carbomer, collagen tripeptide, oat beta-glucan and propylene glycol as a gel matrix to obtain traditional Chinese medicine composition nanogel. The prepared traditional Chinese medicine composition nanogel has the particle size of 120 nm-260 nm, has good drug loading capacity, obviously improves the solubility and bioavailabilityof hydrophobic drugs, inhibits bacteria, diminishes inflammation, stops bleeding and relieves pain, and is definite in curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with antibacterial, anti-inflammatory, hemostatic and analgesic effects and a preparation method thereof. Background technique [0002] Abrasions, cuts, and scratches are common occurrences in daily life. In addition, surgical outpatients often encounter infectious trauma, such as pus-soothing wounds, chronic infectious sinuses, sutured incision infection and dehiscence, decubitus ulcers, and wound infection that has not been debrided and sutured in time. If these wounds are not treated in a timely and effective manner, not only will the healing speed of the wound be delayed, but also problems such as wound infection and inflammation will easily occur, which will bring pain to the patient and seriously affect the speed of wound healing. [0003] Anti-inflammatory drugs or hemostatic drugs are widely used in daily...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/06A61K47/34A61K47/22A61K47/36A61K47/32A61K47/10A61P7/04A61P29/00A61P31/02A61P17/02
CPCA61K9/0014A61K9/06A61K36/48A61K36/53A61K47/10A61K47/22A61K47/32A61K47/34A61K47/36A61K2236/33A61P7/04A61P17/02A61P29/00A61P31/02A61K2300/00
Inventor 胡志文
Owner 江西杏林白马药业股份有限公司
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