66 results about "Vertebrate Animals" patented technology

A device for raising a flying vertebrate capture netting and attaching to a portion of the ceiling wherein there is a hook assembly attached to a telescoping pole for attachment.

The present invention relates to a nucleic acid molecule encoding (I) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (c) a nucleic acid molecule encoding an endonuclease, the amino acid sequence of which is at least 70% identical to the amino acid sequence of SEQ ID NO: 1; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 50% identical to the nucleotide sequence of SEQ ID NO: 2; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein T is replaced by U; (II) a fragment of the polypeptide of (I) having the activity of an endonuclease. Also, the present invention relates to a vector comprising the nucleic acid molecule and a protein encoded by said nucleic acid molecule. Further, the invention relates to a method of modifying the genome of a eukaryotic cell and a method of producing a non-human vertebrate or mammal.

This invention belongs to the field of vertebrate technology, specifically relating to a method for constructing a complex inflammatory animal model in middle-aged and elderly individuals and its related applications. The method includes: selecting adult animals for adaptive feeding, daily subcutaneous injection of D-galactose to establish a susceptibility to aging and oxidative stress, and administering sodium dextran sulfate (DSS) solution within a specific time window to induce intestinal inflammation, forming a complex inflammatory state through gut-hepatic axis interactions. The constructed animal model simultaneously exhibits intestinal inflammatory damage, abnormal hepatic oxidative stress, and aging-related characteristics, realistically simulating the pathological process of gut-hepatic axis dysfunction in middle-aged and elderly individuals. This model is suitable for screening and evaluating drugs, medical nutrition products, and functional foods that improve gut-hepatic axis dysfunction, providing a reliable technical platform for research on related disease mechanisms and the development of interventional substances.

The present invention relates to novel compounds which are useful in agriculture and / or in animal health and in particular to novel isoxazoline compounds, as well as to compositions comprising these compounds. In addition, the present invention relates to the use of a compound or a composition comprising one or more of these compounds in agriculture or animal health and specifically for controlling insect pests or parasitic invertebrate pests. The present invention further relates to intermediate compounds which are useful in preparing the compounds of the present invention.

To provide a feed for marine invertebrates such as abalones and urchins, to provide a method for producing the feed for marine invertebrates, to provide a method for farming marine invertebrates, to provide a method for accelerating the length of shells, and to provide a method for increasing the content of fatty acids.SOLUTION: Provided are: a feed for marine invertebrates, characterized by containing microalgae belonging to the genus Euglena; a method for producing the feed for marine invertebrates, characterized by performing a solidification step of solidifying microalgae belonging to the genus Euglena; a method for farming marine invertebrates and a method for accelerating the length of shells, which comprise feeding microalgae belonging to the genus Euglena to marine invertebrates; and a method for increasing the content of fatty acids, which comprises feeding microalgae belonging to the genus Euglena to increase the content of fatty acids contained in edible parts of marine invertebrates.SELECTED DRAWING: Figure 5

This invention relates to the field of biomimetic teaching aids, and proposes a quadrupedal vertebrate biomimetic teaching aid, comprising a spine unit, a tail component, and a head component. The spine unit includes a connecting plate, a rotating plate, rotating rods, and connecting shafts. The two ends of the rotating rods are rotatably connected to the connecting plate and the rotating plate, respectively. Three rotating rods located on the same side of the connecting plate are of equal length and arranged in a triangular parallel configuration. The two connecting shafts can drive the tail component and the head component to shake. By setting up the connecting plate, rotating plate, rotating rods, and connecting shafts, and utilizing their mutual cooperation, this invention not only allows for adjustment of the axial distance between the two connecting shafts according to actual needs to meet the positional requirements of the biomimetic animal, but also allows the other connecting shaft to rotate synchronously when one is rotated, thereby shaking the head component and tail component separately. This enriches the morphological variations of the biomimetic teaching aid and enhances its teaching and demonstration effects.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A multi-functional system for measuring neurological functions in an animal is provided. The system includes a diagnostic measuring device including a power source. The system further includes one or more stimulators for applying an electrical stimulus to the animal and a plurality of amplifiers. A computing device is connected to the diagnostic measuring device via a connector cable, whereby data is collected after the electrical stimulus is applied to the animal and the data is sent by the connector to the computing device.

The present invention relates to a method for synthesizing calcium-based biominerals, particularly hydroxyapatite (found in vertebrate bones and teeth) and calcium carbonate (found in plankton and corals). This fully biocompatible mineralization strategy not only offer fundamental insights into the biomineralization process, starting from mineral ions to amorphous precursors and eventually to specific minerals, but also contributes to our scientific understanding of life's origin. Furthermore, it showcases great promise for therapeutic applications, such as actively repairing damaged tooth enamel and promoting bone growth.

The present disclosure relates to the field of drug discovery and therapeutics, including systems and methods to predict drug function, to classify or prioritize drugs based on predicted function, and to test known and novel compounds for function in a vertebrate system. The present disclosure also relates to compounds identified using the disclosed systems and methods, the novel mechanisms of action of the compounds, and applications of the compounds as therapeutics, e.g., as cancer therapeutics.

The application belongs to the technical field of pest control, and discloses application of a nitrogen-containing heterocyclic compound in the prevention and treatment of apple snails. The application takes the arginine kinase of the apple snail as an action target, and screens out a nitrogen-containing heterocyclic compound with the activity of killing the apple snail, which is N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-N-(1-hexyl-1H-benzimidazol-2-yl)amine. The nitrogen-containing heterocyclic compound is prepared into a suspension agent or a granule as an active ingredient, and both of them have excellent killing effects on the apple snails. Compared with the existing arginine kinase inhibitor quercetin, the nitrogen-containing heterocyclic compound has higher activity, better selectivity, lower toxicity to vertebrates, and great application potential.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

The invention discloses a farmland invertebrate three-dimensional space long-term monitoring device and method, and relates to the technical field of insect monitoring devices.The farmland invertebrate three-dimensional space long-term monitoring device comprises an overground trapping device, an earth surface trapping device and an underground trapping device, the overground trapping device is installed on a supporting device, and the overground trapping device is used for capturing flying insects; the ground surface trapping device and the underground trapping device are both buried in the land, the ground surface trapping device is used for capturing reptiles on the ground surface, the underground trapping device is used for collecting animal information in the soil, a monitoring device, an environment sensor module and a power module are installed on the supporting device, and the monitoring device is used for monitoring the capturing condition of the ground surface trapping device; the environment sensor module is used for monitoring environment conditions, the monitoring device and the environment sensor module are electrically connected with the power supply module, and the monitoring device and the environment sensor module are electrically connected with the control background. According to the invention, insects on the ground, on the earth surface and under the ground can be monitored for a long time at the same time, and the comprehensiveness of insect condition monitoring is improved.

Nucleic acid immunization is achieved by administering RNA encapsulated within a liposome. The RNA encodes a relevant immunogen, and the liposome has a diameter in the range of 60-180nm, and ideally in the range of 80-160nm. Accordingly, the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm; and (ii) the aqueous core comprises an RNA encoding an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and are thus useful as components in pharmaceutical compositions for immunizing subjects against various diseases.

Immunization with nucleic acids is achieved by delivering a self-replicating RNA encapsulated in a small particle. The RNA encodes an immunogen of interest, and the particle can deliver the RNA by mimicking the delivery function of a natural RNA virus. Accordingly, the invention provides a particle other than a virion for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material that encapsulates a self-replicating RNA molecule encoding an immunogen. Such particles are useful as components of pharmaceutical compositions for immunizing subjects against various diseases.

The present invention discloses a fluorescence in situ hybridization method for co-localization of multiple genes in shellfish hemocytes, belonging to the technical field of cell biology of marine invertebrates. By optimizing the osmotic pressure buffer system and the preparation method, the present invention can stably obtain a monolayer sample with complete and uniform cell morphology. By advancing the cell morphology imaging step, the complete morphological information of cells is obtained and fixed as a reference before implementing the stringent in situ hybridization process. The present invention can achieve in situ visualization of multiple target genes while better preserving the cell morphological structure, which helps to obtain more accurate and stable spatial distribution information of gene expression at the single-cell level, improves the overall reliability of the experiment, and provides a more effective analysis tool for the study of cell functions of marine invertebrates.

The invention belongs to the technical field of pest control, and relates to application of an azo compound as an arginine kinase inhibitor and prevention and control of ampullaria gigas. The azo compound 4-[2-(2-isopropyl-5-methylphenoxy) ethyoxyl]-3-methoxybenzaldehyde (4, 6-dipyrrolidine-1-yl-1, 3, 5-triazine-2-yl) hydrazone obtained through screening can be jointly and stably combined with arginine kinase through multiple types of non-covalent interaction, and the function of an arginine kinase inhibitor is played. When the azo compound provided by the invention is used for preventing and treating ampullaria gigas, an excellent poisoning effect is shown, the activity of the azo compound is higher than that of an existing arginine kinase inhibitor quercetin, and the azo compound is good in selectivity and low in toxicity to vertebrates compared with a traditional molluscicide metaldehyde.

This invention is directed to a monoclonal antibody or an antigen binding fragment thereof targeting the expression and function of CYP1A1 with cross reactivity across the vertebrate taxa. This invention is also directed to nucleic acid molecules, vectors, host cells and compositions comprising the same, as well as methods for use of the same and for producing the same.

The present invention provides an attachment base for sessile aquatic invertebrates that improves the structure of conventional coral attachment plugs and facilitates the promotion of growth and breeding management of sessile aquatic invertebrates in general. [Solution] The attachment substrate 10 for sessile aquatic invertebrates serves as a base for attaching sessile aquatic invertebrates, and includes a frame 1, an alkaline mineral plate 2 which is a member containing alkaline minerals and is placed on and near the attachment surface to which the sessile aquatic invertebrates attach, an internal magnet 3 which is a first magnetic piece and is placed inside the alkaline mineral plate 2, and an external magnet 4 which is a fixing member. The attachment substrate 10 for sessile aquatic invertebrates is fixed onto an in-aquarium shelf 7 which is a non-magnetic object placed between the frame 1 and the external magnet 4 via the attractive force between the internal magnet 3 and the external magnet 4.

The invention relates to heterocyclic compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

The present invention relates to compounds of formula (I), in which the variables have the meanings as defined in the specification, to compositions containing them, to active compound combinations containing them and their use for protecting growing plants and animals from attack or infestation by invertebrate pests, as well as to seeds containing such compounds. [Formula 1] TIFF2025542264000050.tif19170

Antimicrobial defensin peptide variants comprising modified C-terminal fragments of a defensin and nucleic acids encoding the same are disclosed. Compositions comprising the defensin variant peptides and methods of their use to control microbial infections of plants and vertebrate subjects as well as contamination of feedstuffs and foodstuffs are also disclosed.

Low doses of fluralaner or another isoxazoline derivative are administered to an animal such as a pet, typically a dog or a cat, preferentially by administration of a repeated dose, at regular intervals or at varying intervals, each dose being of the same or different amount, which leads to efficacy against arthropods, especially fleas and ticks. Various regimens, galenic forms, posologies, therapeutic indications, combinations with other active or synergistic ingredients, and smart devices or methods for release of doses to the animal can be provided, alone or in combinations.

The invention discloses a device and method for invertebrate behavior ecology research, and relates to the technical field of animal behavior research, the device comprises a starting pipe, a heat insulation assembly and an environmental factor regulation and control assembly, and the heat insulation assembly is internally provided with a plurality of channels communicated with an inlet and an outlet; the inlet is connected with the starting pipe; the environmental factor regulation and control assembly comprises a temperature control assembly and at least two branch pipe groups, the branch pipe groups are in one-to-one correspondence with the outlets, and each branch pipe group is connected and communicated with each outlet; the temperature control assembly can adjust the temperature of each branch pipe group; and an environment stimulation source is placed in the branch pipe group. Single-factor environmental stimulation or multi-factor environmental stimulation is applied to the branch pipe groups, so that the environmental stimulation presented in different branch pipe groups is different; enabling the tested animal in the starting tube to autonomously move in the invertebrate behavior ecology research device; and obtaining selection behavior characteristics and data of the tested animal. According to the method, more systematic and comprehensive behavioral data can be obtained, and the experiment accuracy is improved.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

The present invention relates to novel compounds which are useful in agriculture and / or in animal health and / or household and in particular to novel isoxazoline compounds, as well as to compositions comprising these compounds. In addition, the present invention relates to the use of a compound or a composition comprising one or more of these compounds in agriculture or animal health or household and specifically for controlling insect pests or parasitic invertebrate pests or household pests. The present invention further relates to intermediate compounds which are useful in preparing the compounds of the present invention.

The invention belongs to the technical field of pest control, and particularly relates to application of an aromatic azo-acylhydrazone compound in control of ampullaria gigas. Ampullaria gigas arginine kinase is taken as an action target, the aromatic azo-acylhydrazone compound with the ampullaria gigas killing activity is obtained through screening, and the aromatic azo-acylhydrazone compound is 1-[2-(7-benzal-3-phenyl-3, 3a, 4, 5, 6, 7-hexahydro-2H-indazole-2-yl)-2-oxoethyl]-5-(2, 3, 4, 5, 6-pentafluorophenyl)-3a, 6a-pyrrolo [3, 3, 4] triazole-2-yl)-5-oxoethyl]-5-(2, 3, 4, 5, 6-pentafluorophenyl)-5-(2, 3, 4, 5, 6-pentafluorophenyl)-5-(2, 3, 4, 5, 6-pentafluorophenyl) The invention relates to 2-(2, 4-d) [1, 2, 3] triazole-4, 6 (1H, 5H)-diketone. Test results show that the aromatic azo-acylhydrazone compound is used as an active component to prepare a suspending agent, the suspending agent has an excellent killing effect on pomacea canaliculata, and compared with an existing arginine kinase inhibitor, the aromatic azo-acylhydrazone compound is higher in activity, good in selectivity, low in toxicity to vertebrates and huge in application potential.

Nucleic acid immunization is achieved by administering RNA encapsulated within a pegylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Accordingly, the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid containing a polyethylene glycol moiety, such that the polyethylene glycol is on the exterior of the liposome, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa; and (ii) the aqueous core contains an RNA encoding an immunogen. These liposomes are suitable for in vivo delivery of RNA to a vertebrate cell and are therefore useful as components of pharmaceutical compositions for immunizing individuals against various diseases.

The invention relates to isoxazoline compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.