109 results about "Vertebrate Animals" patented technology

Systems, methods, and computer-readable storage media for measuring spinal canal volume in vertebrates, and more specifically to using Artificial Intelligence (AI) to predict how surgical options will affect spinal canal volume. A system configured as disclosed herein can receive two or more pre-operation medical images capturing at least one functional spinal unit, then calculate an initial spinal canal regional volume using the pre-operation medical images for at least a portion of the at least one functional spinal unit. The system can then calculate, using a neural network, a predicted spinal canal regional volume for at least a portion of the at least one functional spinal unit undergoing various spine surgery options separately, resulting in predicted spinal canal regional volumes corresponding to the plurality of spine surgery options. The system or a surgeon can then select, using that data, one or more of the spine surgery options.

A device for raising a flying vertebrate capture netting and attaching to a portion of the ceiling wherein there is a hook assembly attached to a telescoping pole for attachment.

The invention belongs to the technical field of biomolecular markers, and particularly relates to a cross-animal general skeleton-derived hematopoietic stem cell marker gene set and a screening method thereof. According to the invention, a bone-derived hematopoietic stem cell marker gene set universal across animal categories is constructed for the first time, and the bone-derived hematopoietic stem cell marker gene set comprises at least five of Cdc42, Cbx, Tfam, Denr, Mcts1, Ak2, Ruvbl, Ahcy, Nna and Vdac; the hematopoietic stem cell marker gene set is obtained through cross-species homologous gene screening, the defect that a traditional vertebrate marker has no orthohomology in invertebrates is overcome, accurate recognition of HSC in shells is achieved, the hematopoietic stem cell marker gene set has species universality and cell specificity, the immune state of aquatic animals can be evaluated, disease-resistant breeding can be guided, and the application prospect is wide. And molecular evidence is provided for analyzing an evolution path of a hematopoietic system from invertebrates to vertebrates.

To provide a low-cost land-based aquaculture system for marine invertebrates that does not depend on natural seaweeds.SOLUTION: This land-based aquaculture system comprises: a feed tank for culturing seaweeds serving as feed for marine invertebrates by using seawater; a rearing tank for rearing the marine invertebrates by using seawater; and a gas supply device for supplying a gas containing carbon dioxide at a higher concentration than that in the atmosphere to the seawater in the feed tank.SELECTED DRAWING: Figure 1

The present invention relates to a nucleic acid molecule encoding (I) a polypeptide having the activity of an endonuclease, which is (a) a nucleic acid molecule encoding a polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 1; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2; (c) a nucleic acid molecule encoding an endonuclease, the amino acid sequence of which is at least 70% identical to the amino acid sequence of SEQ ID NO: 1; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 50% identical to the nucleotide sequence of SEQ ID NO: 2; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (e) wherein T is replaced by U; (II) a fragment of the polypeptide of (I) having the activity of an endonuclease. Also, the present invention relates to a vector comprising the nucleic acid molecule and a protein encoded by said nucleic acid molecule. Further, the invention relates to a method of modifying the genome of a eukaryotic cell and a method of producing a non-human vertebrate or mammal.

This invention belongs to the field of vertebrate technology, specifically relating to a method for constructing a complex inflammatory animal model in middle-aged and elderly individuals and its related applications. The method includes: selecting adult animals for adaptive feeding, daily subcutaneous injection of D-galactose to establish a susceptibility to aging and oxidative stress, and administering sodium dextran sulfate (DSS) solution within a specific time window to induce intestinal inflammation, forming a complex inflammatory state through gut-hepatic axis interactions. The constructed animal model simultaneously exhibits intestinal inflammatory damage, abnormal hepatic oxidative stress, and aging-related characteristics, realistically simulating the pathological process of gut-hepatic axis dysfunction in middle-aged and elderly individuals. This model is suitable for screening and evaluating drugs, medical nutrition products, and functional foods that improve gut-hepatic axis dysfunction, providing a reliable technical platform for research on related disease mechanisms and the development of interventional substances.

The present invention relates to novel compounds which are useful in agriculture and / or in animal health and in particular to novel isoxazoline compounds, as well as to compositions comprising these compounds. In addition, the present invention relates to the use of a compound or a composition comprising one or more of these compounds in agriculture or animal health and specifically for controlling insect pests or parasitic invertebrate pests. The present invention further relates to intermediate compounds which are useful in preparing the compounds of the present invention.

To provide a feed for marine invertebrates such as abalones and urchins, to provide a method for producing the feed for marine invertebrates, to provide a method for farming marine invertebrates, to provide a method for accelerating the length of shells, and to provide a method for increasing the content of fatty acids.SOLUTION: Provided are: a feed for marine invertebrates, characterized by containing microalgae belonging to the genus Euglena; a method for producing the feed for marine invertebrates, characterized by performing a solidification step of solidifying microalgae belonging to the genus Euglena; a method for farming marine invertebrates and a method for accelerating the length of shells, which comprise feeding microalgae belonging to the genus Euglena to marine invertebrates; and a method for increasing the content of fatty acids, which comprises feeding microalgae belonging to the genus Euglena to increase the content of fatty acids contained in edible parts of marine invertebrates.SELECTED DRAWING: Figure 5

This invention relates to the field of biomimetic teaching aids, and proposes a quadrupedal vertebrate biomimetic teaching aid, comprising a spine unit, a tail component, and a head component. The spine unit includes a connecting plate, a rotating plate, rotating rods, and connecting shafts. The two ends of the rotating rods are rotatably connected to the connecting plate and the rotating plate, respectively. Three rotating rods located on the same side of the connecting plate are of equal length and arranged in a triangular parallel configuration. The two connecting shafts can drive the tail component and the head component to shake. By setting up the connecting plate, rotating plate, rotating rods, and connecting shafts, and utilizing their mutual cooperation, this invention not only allows for adjustment of the axial distance between the two connecting shafts according to actual needs to meet the positional requirements of the biomimetic animal, but also allows the other connecting shaft to rotate synchronously when one is rotated, thereby shaking the head component and tail component separately. This enriches the morphological variations of the biomimetic teaching aid and enhances its teaching and demonstration effects.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

The utility model relates to the technical field of invertebrate breeding, and discloses an earthworm collecting device for earthworm breeding, which comprises an earthworm breeding box and pulleys arranged on the bottom surface of the earthworm breeding box, vent holes are arranged on two sides of the earthworm breeding box, a breeding collecting device is arranged in the earthworm breeding box, and the breeding collecting device is arranged in the earthworm breeding box. A placement plate is arranged above the breeding collection device, and a breeding induction device is arranged on the top surface of the placement plate. By arranging the two symmetrical earthworm breeding boxes and arranging the telescopic bases and the electric telescopic rods at the bottoms of the breeding boxes, when earthworms are collected, the two breeding boxes only need to be pulled open towards the two sides, and then a color temperature adjusting and controlling lamp and a water spraying plate on one side are controlled, so that the earthworms are attracted by the breeding box on the other side, move to an earthworm outlet and fall into a collecting box; the earthworms can be collected without arranging a suction box, the space in the device is saved, the breeding efficiency is improved, and the device is simple in structure, convenient to operate and high in practicability.

A multi-functional system for measuring neurological functions in an animal is provided. The system includes a diagnostic measuring device including a power source. The system further includes one or more stimulators for applying an electrical stimulus to the animal and a plurality of amplifiers. A computing device is connected to the diagnostic measuring device via a connector cable, whereby data is collected after the electrical stimulus is applied to the animal and the data is sent by the connector to the computing device.

The present invention relates to a method for synthesizing calcium-based biominerals, particularly hydroxyapatite (found in vertebrate bones and teeth) and calcium carbonate (found in plankton and corals). This fully biocompatible mineralization strategy not only offer fundamental insights into the biomineralization process, starting from mineral ions to amorphous precursors and eventually to specific minerals, but also contributes to our scientific understanding of life's origin. Furthermore, it showcases great promise for therapeutic applications, such as actively repairing damaged tooth enamel and promoting bone growth.

The present disclosure relates to the field of drug discovery and therapeutics, including systems and methods to predict drug function, to classify or prioritize drugs based on predicted function, and to test known and novel compounds for function in a vertebrate system. The present disclosure also relates to compounds identified using the disclosed systems and methods, the novel mechanisms of action of the compounds, and applications of the compounds as therapeutics, e.g., as cancer therapeutics.

The application belongs to the technical field of pest control, and discloses application of a nitrogen-containing heterocyclic compound in the prevention and treatment of apple snails. The application takes the arginine kinase of the apple snail as an action target, and screens out a nitrogen-containing heterocyclic compound with the activity of killing the apple snail, which is N-[4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzyl]-N-(1-hexyl-1H-benzimidazol-2-yl)amine. The nitrogen-containing heterocyclic compound is prepared into a suspension agent or a granule as an active ingredient, and both of them have excellent killing effects on the apple snails. Compared with the existing arginine kinase inhibitor quercetin, the nitrogen-containing heterocyclic compound has higher activity, better selectivity, lower toxicity to vertebrates, and great application potential.

The invention discloses a bacillus subtilis MJ-4 microbial inoculum and application thereof in prevention and control of cockroaches, and the microbial inoculum is bacillus subtilis MJ-4 fermentation liquor obtained by taking bacillus subtilis MJ-4 as a strain and performing seed activation and fermentation. According to the invention, the bacillus subtilis MJ-4 with insecticidal broad spectrum is used as a biocontrol bacterium to prevent and control the ravoc of cockroaches, aiming at the problems in the existing prevention and control, the cockroaches are prevented and controlled to generate drug resistance, and the environment-friendly, non-toxic and harmless biological prevention and control are realized; the strain MJ-4 is environment-friendly, can be combined with baits, can well attract cockroaches to eat, has a remarkable killing effect, has no adverse effect on vertebrates, and can be developed and utilized as a good biological control fungicide due to the fact that bacterial powder is easy to produce and low in cost.

Provided is a method for obtaining the germ cell lineage of an oviparous vertebrate more efficiently than conventional techniques. A host oviparous vertebrate is prepared at a developmental stage after the development of black pigmentary cells in the retina and before the formation of multiple layers of germ cells in the genitals, and isolated undifferentiated germ cells from a donor oviparous vertebrate are transplanted into the host oviparous vertebrate.

The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.

The present invention relates to an isolated mosquito extracellular vesicle for use as an immunogenic agent in the prevention of at least one vector-borne disease. The present invention also relates to a vaccine composition comprising at least one mosquito extracellular vesicle. The present invention further relates to the use of a mosquito extracellular vesicle in identifying at least one immunogenic peptide capable of reducing, in a vertebrate, the transmission of a vector-borne disease when the vertebrate is bitten by the vector, and to a method for identifying at least one immunogenic peptide capable of blocking, in a vertebrate, the transmission of a vector-borne disease when the vertebrate is bitten by the vector, the method comprising a step of identifying in vitro at least one target antibody present in an animal serum sample immunised against mosquito extracellular vesicles.

The invention discloses a farmland invertebrate three-dimensional space long-term monitoring device and method, and relates to the technical field of insect monitoring devices.The farmland invertebrate three-dimensional space long-term monitoring device comprises an overground trapping device, an earth surface trapping device and an underground trapping device, the overground trapping device is installed on a supporting device, and the overground trapping device is used for capturing flying insects; the ground surface trapping device and the underground trapping device are both buried in the land, the ground surface trapping device is used for capturing reptiles on the ground surface, the underground trapping device is used for collecting animal information in the soil, a monitoring device, an environment sensor module and a power module are installed on the supporting device, and the monitoring device is used for monitoring the capturing condition of the ground surface trapping device; the environment sensor module is used for monitoring environment conditions, the monitoring device and the environment sensor module are electrically connected with the power supply module, and the monitoring device and the environment sensor module are electrically connected with the control background. According to the invention, insects on the ground, on the earth surface and under the ground can be monitored for a long time at the same time, and the comprehensiveness of insect condition monitoring is improved.

Nucleic acid immunization is achieved by administering RNA encapsulated within a liposome. The RNA encodes a relevant immunogen, and the liposome has a diameter in the range of 60-180nm, and ideally in the range of 80-160nm. Accordingly, the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer has a diameter in the range of 60-180nm; and (ii) the aqueous core comprises an RNA encoding an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and are thus useful as components in pharmaceutical compositions for immunizing subjects against various diseases.

Immunization with nucleic acids is achieved by delivering a self-replicating RNA encapsulated in a small particle. The RNA encodes an immunogen of interest, and the particle can deliver the RNA by mimicking the delivery function of a natural RNA virus. Accordingly, the invention provides a particle other than a virion for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material that encapsulates a self-replicating RNA molecule encoding an immunogen. Such particles are useful as components of pharmaceutical compositions for immunizing subjects against various diseases.

The present invention discloses a fluorescence in situ hybridization method for co-localization of multiple genes in shellfish hemocytes, belonging to the technical field of cell biology of marine invertebrates. By optimizing the osmotic pressure buffer system and the preparation method, the present invention can stably obtain a monolayer sample with complete and uniform cell morphology. By advancing the cell morphology imaging step, the complete morphological information of cells is obtained and fixed as a reference before implementing the stringent in situ hybridization process. The present invention can achieve in situ visualization of multiple target genes while better preserving the cell morphological structure, which helps to obtain more accurate and stable spatial distribution information of gene expression at the single-cell level, improves the overall reliability of the experiment, and provides a more effective analysis tool for the study of cell functions of marine invertebrates.

An object of the present invention is to provide, for example, a therapeutic agent for hepatic disorders using a specific mesenchymal stem cell line derived from an adipose tissue (ASCL), the therapeutic agent being capable of being preserved and stably supplied and having a better therapeutic effect on hepatic disorders. A feature of the present invention is to use a mesenchymal stem cell line derived from an adipose tissue, the mesenchymal stem cell line having been produced by a production method comprising: (A) inducing differentiation of one or more cells selected from a stromal vascular fraction of a vertebrate animal adipose tissue comprising a mesenchymal stem cell, an adipose progenitor cell, and a stromal cell into a mature adipocyte; and (B) inducing dedifferentiation of the mature adipocyte obtained in step (A) to obtain a mesenchymal cell line derived from the vertebrate animal adipose tissue.

The utility model discloses a high-flux small aquatic animal metabolic rate measuring device which comprises a test cylinder, a placing table, a breathing chamber and a breathing cup, a temperature controller is connected in the test cylinder, a main body pipeline is connected to the upper side of the placing table, a water pump is fixedly connected in the test cylinder, and a water conveying pipe is fixedly connected between the water pump and the main body pipeline; covers are arranged on the front side and the rear side of the breathing chamber, a round hole is formed in the exterior of the main body pipeline, a single-pass small pipe is fixedly connected to the exterior of the round hole, a flow stabilizing mechanism is installed in the breathing chamber, a water outlet pipe is fixedly connected to the exterior of the breathing chamber, a regulating valve is fixedly connected to the exterior of the water outlet pipe, and an oxygen dissolving instrument is installed in the breathing cup; the device can be used for measuring the metabolic rate of various aquatic invertebrates, tadpoles, fishes and other small aquatic animals, can realize high-flux measurement of a plurality of samples at the same time, has portability, is easy to assemble and carry, and can ensure the experiment precision by adjusting the water flow speeds of the pipelines to be relatively consistent.

The invention belongs to the technical field of pest control, and relates to application of an azo compound as an arginine kinase inhibitor and prevention and control of ampullaria gigas. The azo compound 4-[2-(2-isopropyl-5-methylphenoxy) ethyoxyl]-3-methoxybenzaldehyde (4, 6-dipyrrolidine-1-yl-1, 3, 5-triazine-2-yl) hydrazone obtained through screening can be jointly and stably combined with arginine kinase through multiple types of non-covalent interaction, and the function of an arginine kinase inhibitor is played. When the azo compound provided by the invention is used for preventing and treating ampullaria gigas, an excellent poisoning effect is shown, the activity of the azo compound is higher than that of an existing arginine kinase inhibitor quercetin, and the azo compound is good in selectivity and low in toxicity to vertebrates compared with a traditional molluscicide metaldehyde.

This invention is directed to a monoclonal antibody or an antigen binding fragment thereof targeting the expression and function of CYP1A1 with cross reactivity across the vertebrate taxa. This invention is also directed to nucleic acid molecules, vectors, host cells and compositions comprising the same, as well as methods for use of the same and for producing the same.

The present invention provides an attachment base for sessile aquatic invertebrates that improves the structure of conventional coral attachment plugs and facilitates the promotion of growth and breeding management of sessile aquatic invertebrates in general. [Solution] The attachment substrate 10 for sessile aquatic invertebrates serves as a base for attaching sessile aquatic invertebrates, and includes a frame 1, an alkaline mineral plate 2 which is a member containing alkaline minerals and is placed on and near the attachment surface to which the sessile aquatic invertebrates attach, an internal magnet 3 which is a first magnetic piece and is placed inside the alkaline mineral plate 2, and an external magnet 4 which is a fixing member. The attachment substrate 10 for sessile aquatic invertebrates is fixed onto an in-aquarium shelf 7 which is a non-magnetic object placed between the frame 1 and the external magnet 4 via the attractive force between the internal magnet 3 and the external magnet 4.

The invention relates to heterocyclic compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

The present invention relates to compounds of formula (I), in which the variables have the meanings as defined in the specification, to compositions containing them, to active compound combinations containing them and their use for protecting growing plants and animals from attack or infestation by invertebrate pests, as well as to seeds containing such compounds. [Formula 1] TIFF2025542264000050.tif19170