9 results about "Dinitroaniline" patented technology

The present disclosure relates to a method for controlling weeds of Rottboellia genus with herbicidal combinations / compositions comprising chloroacetamide herbicides and dinitroaniline herbicide. The present disclosure further provides a method for controlling weeds using the herbicidal combination possessing enhanced efficacy over the individual herbicides.

This invention relates to the field of organic chemical synthesis technology, specifically to a method for preparing 2,4-dinitroaniline. The method comprises: S1, nitrification of benzene in a concentrated sulfuric acid system to obtain a system containing nitrobenzene; S2, dilution of the nitrobenzene-containing system with water, followed by catalytic hydrogenation to convert the nitrobenzene to aniline; after the reaction, the catalyst is filtered off to obtain a system containing aniline; S3, para-nitration of the aniline-containing system with concentrated nitric acid; after the reaction, dehydration of the system, followed by ortho-nitration of the system with concentrated nitric acid; and post-treatment to obtain 2,4-dinitroaniline. This preparation method is green, safe, efficient, simple to operate, low in cost, uses inexpensive raw materials, and yields high purity of the target product, making it more suitable for industrial applications.

The present invention relates to a method for determining the presence of lung cancer in a subject. The method comprises: (i) determining the level of one or more biomarkers in a sample from the subject; and (ii) comparing the level of said one or more biomarkers with the level of said one or more metabolites in a control sample to determine whether lung cancer is present in the subject. The biomarkers are selected from: 2-methoxyestrone 3-sulfate, testosterone glucuronide, androsterone glucuronide, 5a-dihydrotestosterone sulfate, corticrocin, octanoic acid, beta-citryl-L-glutamic acid, 2-hydroxymuconic semialdehyde, 5,6,11-dodecatriynoic acid, creatine riboside, 3-(Carboxymethyl)-3-hydroxypentanedioic acid, adenosine phosphosulfate, 7,8-dihydroneopterin 3'-phosphate, cis,cis,cis-10,13,16-Docosatrienoyl-CoA, inosine, N-(2,4-Dinitrophenyl)-2,4-dinitroaniline, prostaglandin M, pentadecenoic acid, PE(22:0 / P-18:0), carbamoyl phosphate, 2-hydroxy-3-oxohexanedioic acid, galactosylceramide (d18:1 / 22:0) and PE-NMe2(18:1(11Z) / 22:1(13Z)).

This invention relates to the field of catalyst technology, providing a supported ruthenium-based catalyst, its preparation method, and its application. The supported ruthenium-based catalyst provided by this invention comprises a support and an active metal Ru; the active metal Ru is dispersed on the surface of the support in the form of elemental atom clusters and Ru oxide clusters; the elemental Ru atom clusters are dispersed around the Ru oxide clusters; the support is an oxygen-containing support. The supported ruthenium-based catalyst provided by this invention exhibits high hydrogenation selectivity and activity. When applied to the selective hydrogenation reduction reaction of 2,4-dinitroaniline, it can effectively improve the conversion rate of the reactants and the selectivity of the target product, 4-nitro-o-phenylenediamine. The preparation method provided by this invention is simple, easy to operate, and suitable for large-scale production.

The invention discloses a novel method for synthesizing aminobenzimidazolone and derivatives thereof through water-phase carbonylation of a dinitro aniline compound, which comprises the following steps: taking a dinitro compound and carbon monoxide as raw materials, taking water as a solvent, adding a catalyst and a cocatalyst, and carrying out carbonylation reaction at a certain temperature and pressure to synthesize the aminobenzimidazolone compound. According to the invention, the problems of three wastes and solvent recovery caused by using an inert solvent as a reaction solvent in the existing carbonylation process are solved; the process route and production time are shortened, the yield is improved, and the route cost is reduced; water is adopted as a synthesis solvent and an inorganic base cocatalyst, the catalyst is good in dissolvability, the catalyst and the product are filtered and separated, the product purity is high, and the catalyst and the inorganic base can be directly used mechanically.

The invention discloses a 5-fluoro-3-methyl-2, 4-dinitroaniline compound as well as a preparation method and application thereof, and belongs to the technical field of compound preparation. The compound is prepared by the following method: reacting 1, 3-difluoro-5-toluene at the high temperature of 100-160 DEG C by using fuming sulfuric acid and sodium nitrate as nitrating agents for 6-8 hours, cooling, separating out by using ice water after the temperature is reduced to room temperature, filtering, washing and drying to obtain the 1, 5-difluoro-3-methyl-2, 4-dinitrobenzene. The preparation method comprises the following steps: dissolving 1, 5-difluoro-3-methyl-2, 4-dinitrobenzene in tetrahydrofuran, slowly dropwise adding an ammonia water solution, and naturally volatilizing to obtain the 5-fluoro-3-methyl-2, 4-dinitroaniline (DFDNTN). The melting point (127.5 DEG C) of the prepared 5-fluoro-3-methyl-2, 4-dinitroaniline is higher than an ideal melting point range, but the 5-fluoro-3-methyl-2, 4-dinitroaniline can be used as a single component in a eutectic mixture, the decomposition rate is higher and is 295 DEG C, and the impact sensitivity is 35J; and the friction sensitivity is not lower than 360 N. The detonation velocity is 7210m s <-1 >, and the detonation pressure is 21.14 Gpa, which is superior to that of TNT. And the explosive is expected to become a casting carrier explosive for replacing TNT.

The application belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 2-methyl-8-nitroquinoline. The method comprises the following steps: in an inert gas atmosphere, under the action of an oxidant, o-nitroaniline is first reacted with a protonic acid, and then an aldehyde compound is added to perform a condensation reaction, and 2-methyl-8-nitroquinoline is obtained. In the condensation process, the inert gas protection is adopted to avoid the generation of tar-like by-products in the reaction system, and the yield and purity of 2-methyl-8-nitroquinoline are improved. A new type of oxidant, such as 1,2-dinitrobenzene, dinitrobenzene, 3,5-dinitroaniline and 2,4-dinitroaniline, is adopted to avoid the participation of the substrate o-nitroaniline in the reaction as an oxygen source, and the yield and purity of the product are improved. Meanwhile, the oxidant itself is completely or partially generated into o-nitroaniline, which can be used as a substrate to react, and the yield of the product is further improved. The reaction condition is mild, raw materials are cheap, and the method is suitable for industrial production.

The invention discloses a preparation method of 6-fluoro-3-methyl-2, 4-dinitroaniline, which comprises the following steps: reacting 3, 4-difluorotoluene for 6 hours at the high temperature of 160 DEG C by using fuming sulfuric acid and sodium nitrate as nitrating agents, cooling, separating out by using ice water after the temperature is reduced to room temperature, filtering, washing and drying to obtain 1, 2-difluoro-4-methyl-3, 4-dinitroaniline. And 2, 5-dinitrobenzene (qDFDNT). The preparation method comprises the following steps: dissolving 1, 2-difluoro-4-methyl-3, 5-dinitrobenzene in tetrahydrofuran, slowly dropwise adding an ammonia water solution, and naturally volatilizing to obtain the 6-fluoro-3-methyl-2, 4-dinitroaniline (qDFDNTN). The 6-fluoro-3-methyl-2, 4-dinitroaniline prepared by the invention has a proper melting point (128.5 DEG C), a stable compound, a high decomposition temperature (284 DEG C) and impact sensitivity of not less than 40 J; and the friction sensitivity is not lower than 360 N. And the explosive has excellent safety performance and can be used as any component in eutectic fusion casting carrier explosives.

A method for determining the presence of lung cancer in a subject comprises: (i) determining the level of one or more biomarkers in a sample from the subject; and (ii) comparing the level of said one or more biomarkers with the level of said one or more metabolites in a control sample to determine whether lung cancer is present in the subject. The biomarkers are selected from: 2-methoxyestrone 3-sulfate, testosterone glucuronide, androsterone glucuronide, 5a-dihydrotestosterone sulfate, corticrocin, octanoic acid, beta-citryl-L-glutamic acid, 2-hydroxymuconic semialdehyde, 5,6,11-dodecatriynoic acid, creatine riboside, 3-(carboxymethyl)-3-hydroxypentanedioic acid, adenosine phosphosulfate, 7,8-dihydroneopterin 3’-phosphate, cis,cis,cis-10,13,16-docosatrienoyl-CoA, inosine, N- (2,4-dinitrophenyl)-2,4-dinitroaniline, prostaglandin M, pentadecenoic acid, PE(22:0 / P-18:0), carbamoyl phosphate, 2-hydroxy-3-oxohexanedioic acid, galactosylceramide (d18:1 / 22:0) and PE-NMe2(18:1(11Z) / 22:1(13Z)). The biomarkers may be detected using mass spectrometry, or by enzyme-linked immunosorbent assay (ELISA). Preferably, the sample is a urine sample.