Patents
Literature
37 results about "Screening study" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Banisterine derivant and uses thereof
The invention relates to a yageine derivative and salts of compounds. The invention synthesizes the novel yageine derivative compounds which can strengthen the antineoplastic activity and reduce the toxicity of a nervous system through the structural modification to locus 1, 2, 3, 7 and 9 of beta-carboline parent nuclei of yageine. The compounds can be used for preparing drugs used to treat various tumor diseases through the screening study of in vivo and in vitro anti-tumor experimental models.
Owner:XINJIANG HUASHIDAN PHARMA RES
High-Throughput Organ-Targeted Microinjection System
InactiveUS20160051353A1Efficient deliveryCompounds screening/testingDiagnostics using lightTemplate matchingPressure.drive
Automatic system for efficient delivery of biologics into target organs of zebrafish larvae for high-throughput in vivo screening. The system includes a reservoir containing zebrafish larvae immersed in a hydrogel in its liquid state. A microfluidic component removes a droplet of the hydrogel having a single zebrafish larva contained therein and deposits the droplet on a surface for receiving an array of hydrogel droplets. Structure or substances is provided for inducing the larva to assume a dorsal or lateral orientation within the droplet. A cooler cools the surface to solidify the hydrogel droplets thereby to immobilize the larvae for observation by an optical arrangement that identifies target organs in each larva using an image template-matching algorithm. A pressure driven microinjection needle injects biologics into the target organ of the zebrafish larva for screening studies.
Owner:MASSACHUSETTS INST OF TECH
Three-dimensional tumor model decellularization porous scaffold, construction method and application thereof
ActiveCN107988158AImprove adhesionPromote growthCell culture supports/coating3D cultureCell-Extracellular MatrixCell adhesion
The invention belongs to the fields of cell biology and tumor tissue engineering materials and provides a three-dimensional tumor model decellularization porous scaffold, a construction method and application thereof. The whole pig lung scaffold is prefrozen, a uniform part without obvious bronchi is selected and sliced, purified water and PBS are added for cleaning until no blood streak is formed, removing cells with sodium dodecyl sulfate and TritonX-100, and freezing, drying and chemical crosslinking methods are adopted, so that a crosslinked decellularization pig lung three-dimensional tumor model scaffold is obtained. The three-dimensional tumor model decellularization porous scaffold provided by the invention has the advantages that decellularization matrix sourced from pig lung tissues is taken as a scaffold material for constructing a tumor model, on the basis of effectively removing cell components, a pulmonary alveolus-bronchus structural vein network is reserved as soon as possible, a natural extracellular matrix microenvironment can be simulated, and cell adhesion, growth and proliferation are facilitated. The in vitro constructed three-dimensional tumor model after cells are inoculated has a tissue structure closer to an in vivo tissue and is applicable to screening study of anticancer drugs.
Owner:DALIAN UNIV OF TECH
Chromatographic column decorated by lipid rafts and preparation method thereof and application in screening of traditional Chinese medicine anti-neoplastic activity sites
ActiveCN103134880AGood repeatabilityExtended service lifeComponent separationChromatographic separationLipid formation
The invention discloses a chromatographic column decorated by lipid rafts. The chromatographic column is a silica gel chromatographic column which is decorated with the lipid rafts on the surface. A TrkA lipid raft-sillica gel stationary phase chromatographic system is built firstly. Stationary phase can be combined with medicinal specificity of tyrosine kinase receptors as a target spot, and then reservation is produced, but non-reservation behavior is not existed in the TrkA lipid raft-sillica gel chromatographic column of the tyrosine kinase target spot medicines. Lipid raft-sillica gel chromatograph which is rich in TrkA receptors is a novel medicine screening model which has a living being affiliation character and is capable of selective recognition medicines, wherein the medicines are reacted with the TrkA receptors. The chromatographic system is different from the traditional chromatographic system and has double characters of chromatograph separation and activity recognition. Therefore, the chromatographic system can be used for guide medicine screening study where the TrkA receptors served as drones. The chromatographic column decorated by the lipid rafts is used through different time and different moving phases, and the TrkA lipid raft-sillica gel stationary phase chromatographic system is proved stable. The chromatographic column is good in repeatability, long in service life and has good application prospects. The invention discloses a manufacturing method of the chromatographic column decorated by the lipid rafts.
Owner:JIANGSU UNIV
Group of substituted benzoheterocycle amine derivatives and preparation method and related application thereof as IMPDH (inosine monophosphate dehydrogenase) inhibitor
ActiveCN103992310AOrganic active ingredientsOrganic chemistryInosine-5′-monophosphate dehydrogenaseScreening study
The invention discloses a group of substituted benzoheterocycle amine derivatives and a preparation method and related application thereof as an IMPDH (inosine monophosphate dehydrogenase) inhibitor. The IMPDH inhibitor has good application prospects in virus resistance, immunosuppression, tumor resistance, bacterium resistance, parasite resistance and the like. In the invention, a new-structure IMPDH inhibitor shown by the formula (I) is obtained through the design, synthesis and activity screening study on an active compound targeting IMPDH, and a foundation is laid for the development and application of the compounds as the medicines and medicinal compositions thereof with related effects such as virus resistance, tumor resistance, immunosuppression and the like.
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Building of in-vitro three-dimensional cell model of breast cancer and application of in-vitro three-dimensional cell model in research of drug resistance mechanism and reversal agents screening
InactiveCN104232584AReduce intakeIncrease intakeMicrobiological testing/measurementTumor/cancer cellsMedicineHuman breast
The invention relates to building of an in-vitro three-dimensional cell model of a breast cancer and an application of the in-vitro three-dimensional cell model in research of a drug resistance mechanism and reversal agents screening. A certain amount of human breast cancer MCF-7 cells are planted on a Millicell cell culture chamber cell by applying a'3D no base and embedded' method; and a three-dimensional multi-layer cell model of a human breast cancer MCF-7 cell, of which the thickness is about 40 microns, is formed by cultivation and the number of layers is 10-12. Transport kinetics and consuming behaviors of chemotherapy adriacin doxorubicin are investigated on the MCF-7 multi-layer cell model by single use and combination of P-GP inhibitors LY335979 to prove the drug resistance in the culture process; and the in-vitro three-dimensional cell model is applied to screening of an adriamycin resistance-reversal agent ginsenoside 20(S)-Rh2.
Owner:CHINA PHARM UNIV
Processing method of green fructus forsythiae in production place
The invention relates to a processing method of a traditional Chinese medicine in a production place, and in particular relates to a processing method of a traditional Chinese medicine green fructus forsythiae. The method comprises the following steps of: respectively adopting a drying method, an evaporation method and a boiling method to carry out processing in the production place on the collected green fructus forsythiae, taking forsythin, extract and volatile oil as evaluation indexes and carrying out screening and researching on the processing method of the green fructus forsythiae in the production place. In the green fructus forsythiae processed by the processing method of the green fructus forsythiae in the production place, by detection, the content of the forsythin and the extract of the green fructus forsythiae treated by the drying method, the evaporation method and the boiling methods is increased by different degrees compared with that of a crude product, wherein the increase sequence is such as the boiling method, the evaporation and the drying method. Compared with that of the crude product, the content of the volatile oil in the green fructus forsythiae treated by the evaporation method and the boiling method is increased by different degrees while the content of the volatile in the green fructus forsythiae treated by the drying method is reduced.
Owner:SHAANXI UNIV OF CHINESE MEDICINE
Traditional Chinese medicine extract for suppressing generation of in-vitro glycosylation product and extraction method
InactiveCN102824463ABest mix ratioMetabolism disorderCardiovascular disorderResearch ObjectScreening study
The invention discloses a traditional Chinese medicine extract. The extract includes the rehmanniae praeparatum and fructus corni separated decoction aqueous extract solution aqueous extract, the rehmanniae praeparatum and fructus corni combined decoction aqueous extract solution aqueous extract, the rehmanniae praeparatum and fructus corni separated decoction and combined decoction aqueous extract drug serum, the effective parts of rehmanniae praeparatum (iridoid glycoside, oligosaccharide and polysaccharide), the effective parts of fructus corni (iridoid glycoside, polysaccharide and triterpenic acid), and the orthogonal compatibility combination of the 6 effective parts. In the effective parts, the content of catalpol in the iridoid glycoside part of the rehmanniae praeparatum is 1.91%, the purity of the polysaccharide is 68.52%, the content of two glycosides in the iridoid glycoside part of the fructus corni is 44.8%, etc. The traditional Chinese medicine extract is subjected to relatively systematic screening research by taking the in-vitro AGEs generation model as a research object, and the result indicates that the traditional Chinese medicine extract can obviously suppress the generation of in-vitro glycosylation products, namely fructosamine (early stage) and AGEs (late stage), thus the invention provides an experimental basis for clinically using rehmanniae praeparatum and fructus corni to treat the vascular diseases such as diabetic nephropathy and the like with the traditional Chinese medicine.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
High-throughput electrochemical detection device and high-throughput electrochemical detection method
ActiveCN107764884AEase of screening studiesImprove detection efficiencyMaterial electrochemical variablesEngineeringScreening study
The invention relates to a high-throughput electrochemical detection device which is used for detecting an electrolyte sample. The high-throughput electrochemical detection device comprises a detection component and a control processing unit, wherein a plurality of probes and a plurality of conversion elements correspondingly connected with the probes are arranged on the detection component in anarray manner; the conversion elements are electrically connected to the control processing unit; the probes can be used for simultaneously detecting multiple electrolyte samples; the conversion elements are used for converting signals detected by the probes into digital signals and transmitting the digital signals to the control processing unit; the control processing unit is used for processing the digital signals transmitted by the conversion elements to form a detection result. The invention also provides a high-throughput electrochemical detection method. The high-throughput electrochemical detection device and the high-throughput electrochemical detection method that are provided by the invention have the advantage that the multiple electrolyte samples can be detected at one time, andthe detection efficiency is high, so that the screening study on a large-scale material is facilitated.
Owner:成都大超科技有限公司
Producing method of transgenic mouse containing anthropogenic proto-oncogene c-Ha-ras and application thereof
The invention provides a producing method of a transgenic mouse integrated with anthropogenic proto-oncogene c-Ha-ras DNA in genomes. DNA transferred contains four coding exons, introns and regulatory sequences of human c-Ha-ras gene. The regulatory sequences are preferentially selected from the promoter region of the human c-Ha-ras gene and a poly A tailing signal sequence. The transgenic mouse,filial generation, embryo, organ and / or derived cells produced with the method can be used for canceration mechanism study, carcinogen or cancer inhibitor screening research and pre-clinical safety evaluation of drugs.
Owner:NAT INST FOR FOOD & DRUG CONTROL
specific primer, kit and identification method for identifying traditional Chinese medicine kwangsi gecko
ActiveCN106868194AThe identification result is accurateSmall molecular weightMicrobiological testing/measurementDNA/RNA fragmentationMedicinal herbsAdulterant
The invention provides a specific primer, a kit and an identification method for identifying traditional Chinese medicine kwangsi gecko. A lot of primers are designed based on a CYTB gene of the kwangsi gecko; the primer with species specificity is screened out through the screening study of a large amount of primers; the primer is used for identifying the traditional Chinese medicine kwangsi gecko, so that the kwangsi gecko medicinal material can be accurately separated from other adulterants, a PCR (Polymerase Chain Reaction) amplification product is only 100 to 250bp, the molecular weight is low, a lot of traditional Chinese medicine kwangsi gecko is ensured to be identified within a short time, and an identification result is accurate, stable, reliable and high in sensitivity.
Owner:BEIJING JIANSHENG PHARMA
Rotor magnetic ring of high-efficiency micromotor and manufacturing method of rotor magnetic ring
ActiveCN104333156AGood injection processPrecise Manufacturing DimensionsMagnetic circuit rotating partsMagnetic circuit characterised by magnetic materialsNylon 6Micromotor
The invention discloses a rotor magnetic ring of a high-efficiency micromotor and a manufacturing method of the rotor magnetic ring. The rotor magnetic ring is made by ferrite magnetic powder, poly (1,9-nonyl para-phenylene diamide), polylaurolactam, nylon 6 or clay nano composite and oleic acid through injection molding. Optimal constitutional raw materials and an optimal using quantity ratio are acquired through a lot of experiment screening study; by the rotor magnetic ring manufactured by the method, mass of a motor rotor can be reduced, weight of the whole motor can be reduced, efficiency of the motor is improved, the motor is lower in noise, higher in running frequency and large in pulling-out torque, a major breakthrough on mass of the motor is made, and remarkable technological progress is made.
Owner:JIANGSU LEILI MOTOR
Botanical compound pesticide capable of preventing and treating microorganisms of tea brown blight of tea tree
InactiveCN107593771ANo threat to healthControl blightBiocideFungicidesBULK ACTIVE INGREDIENTScreening study
The invention relates to a botanical compound pesticide capable of preventing and treating microorganisms of tea brown blight of a tea tree. The botanical compound pesticide is composed of the following substances in proportion: 2 to 5 kg of amino acid, 0.5 to 1 kg of Oxymatrine, 0.01 to 0.5 kg of Zhongshengmycin and 50 to 150 L of a Bacillus subtilis CGMCC2010146 fermentation broth, wherein the content of Bacillus subtilis in the Bacillus subtilis CGMCC2010146 fermentation broth is 5 * 10<8> to 8 * 10<10> cfu / mL. Through a great amount of screening studies, the applicant of the invention finds that compounding of the Oxymatrine, the Zhongshengmycin and the Bacillus subtilis CGMCC2010146 fermentation broth can well prevent and treat the tea brown blight; the combination of active ingredients of the Oxymatrine, the Zhongshengmycin and the Bacillus subtilis CGMCC2010146 fermentation broth can exert synergetic effects, is truly free of toxicity, harm and pollution, may not threaten the health of human, is green and safe, and maintains excellent quality of tea leaves.
Owner:XINYANG AGRI & FORESTRY UNIV
A screening method for low-nitrogen-tolerant barley
ActiveCN108184633BReduce the amount of applicationReduce the burden onCalcareous fertilisersMagnesium fertilisersBiotechnologyLow nitrogen
Provided is a screening method for low-nitrogen-resistant barley. Overground parts of the barley are used as screening research objects, a hydroponic method is used for selecting the shoot dry weightof the barley in the seedling stage as a screening index, low-nitrogen-resistant barley varieties are screened out, the appropriate low nitrogen stress concentration is determined, and the product ofrelative single plant nitrogen uptake and relative nitrogen physiological utilization efficiency is used for judging the tolerance degree of the barley to the low nitrogen environment to some extent to reflect the low nitrogen tolerance of barley materials. The low nitrogen tolerance of the barley is characterized by the shoot dry weight and the product of the relative single plant nitrogen uptakeand the relative nitrogen physiological utilization efficiency, which is more accurate compared with the characterization of low nitrogen tolerance by one aspect of nitrogen uptake or nitrogen physiological utilization efficiency. According to the barley screened by the method, the application rate of nitrogen fertilizers is effectively reduced, the environmental burden is reduced, and the application rate of the nitrogen fertilizers can be reduced to at least about one third of the total nitrogen to greatly alleviate the environmental pressure.
Owner:SHANGHAI ACAD OF AGRI SCI
A group of substituted benzheterocyclic amine derivatives and their preparation methods and related applications as impdh inhibitors
ActiveCN103992310BOrganic active ingredientsOrganic chemistryCombinatorial chemistryPerylene derivatives
The invention discloses a group of substituted benzoheterocycle amine derivatives and a preparation method and related application thereof as an IMPDH (inosine monophosphate dehydrogenase) inhibitor. The IMPDH inhibitor has good application prospects in virus resistance, immunosuppression, tumor resistance, bacterium resistance, parasite resistance and the like. In the invention, a new-structure IMPDH inhibitor shown by the formula (I) is obtained through the design, synthesis and activity screening study on an active compound targeting IMPDH, and a foundation is laid for the development and application of the compounds as the medicines and medicinal compositions thereof with related effects such as virus resistance, tumor resistance, immunosuppression and the like.
Owner:MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
A method for screening high-efficiency varieties of double-cropping super rice with water and fertilizer synergy
Owner:HUNAN HYBRID RICE RES CENT
Chromatographic column modified with lipid rafts and its preparation method and its application in screening of antitumor active sites of traditional Chinese medicine
ActiveCN103134880BGood repeatabilityExtended service lifeComponent separationChromatographic separationSilica gel
Owner:JIANGSU UNIV
New vascular tissue generation method
The invention relates to a new vascular tissue generation method. The method comprises, removing thoracic aorta, heart tissue, liver tissue, spleen tissue, lung tissue, kidney tissue and colon tissue from a mouse or a rat under a sterile condition; carrying out a combination of the removed tissues and the culture plate to generate the new vascular tissues respectively corresponding to the aorta, the heart tissue, the liver tissue, the spleen tissue, the lung tissue, the kidney tissue and the colon tissue. With the method provided by the present invention, disadvantages of cumbersome quantity and not high survival rate are overcome; a simple and convenient model of the new vascular tissue generating is established, wherein the model can be widely used; the method further can be applicable for screening studies of the tumor angiogenesis inhibitor.
Owner:XI AN JIAOTONG UNIV
Screening method for actinomycetes with effect of inhibiting anthrax pathogenic bacteria
InactiveCN109355188AQuick filterScreening is intuitiveMicrobiological testing/measurementMicroorganism based processesBacteroidesScreening method
The invention discloses a screening method for actinomycetes with an effect of inhibiting anthrax pathogenic bacteria, and relates to the technical field of microorganisms. The method comprises the following steps of A, sample collection, B, soil suspension preparation, C, culturing, D, preliminary screening and E, secondary screening, and finally the actinomycetes with the effect of inhibiting the anthrax pathogenic bacteria is screened out. The actinomycetes with the effect of inhibiting the anthrax pathogenic bacteria can be quickly screened out in the modes of preliminary screening and secondary screening, the rate of novel antimicrobial active bacterial strains and antimicrobial active substances can be increased, the whole screening process is quick, the operation is simple, and thelabor intensity is lower; the antimicrobial active bacteria and the actinomycetes can be quickly, visually and efficiently screened out, and great convenience is provided for screening study of the antimicrobial active bacteria and the actinomycetes.
Owner:NINGDE NORMAL UNIV +1
A specific primer, kit and identification method for identifying donkey-derived components
ActiveCN109593864BAccurate specificityThe identification result is accurateMicrobiological testing/measurementDNA/RNA fragmentationScreening studyGene
The invention provides a specific primer, kit and identification method for identifying donkey-derived components. A large number of primers are designed based on the CYT B and COX-1 genes of donkeys, and a large number of primers are screened and studied. Specific primers, using the above primers to identify donkey-derived components in the test mixture, can accurately separate donkeys from other confounding products, and the PCR amplification product is only 50-150bp, with a small molecular weight, ensuring its A large number of donkey-derived components in the mixture are identified in a short period of time, and the identification results are accurate, stable, reliable, and highly sensitive.
Owner:TONG REN TANG TECH CO LTD
In silico process for selecting protein formulation excipients
ActiveUS20190062948A1Structure miniaturizationEliminate structureLibrary screeningData visualisationScreening methodBiology
The invention relates to an in silico screening method to identify candidate excipients for reducing aggregation of a protein in a formulation. The method combines computational molecular modeling and molecular dynamics simulations to identify sites on a protein where non-specific self-interaction and interaction of different test excipients may occur, determine the relative binding energies of such interactions, and select one or more test excipients that meet specified interaction criteria for use as candidate excipients in empirical screening studies.
Owner:MERCK SHARP & DOHME LLC
Banisterine derivant and uses thereof
The invention relates to a yageine derivative and salts of compounds. The invention synthesizes the novel yageine derivative compounds which can strengthen the antineoplastic activity and reduce the toxicity of a nervous system through the structural modification to locus 1, 2, 3, 7 and 9 of beta-carboline parent nuclei of yageine. The compounds can be used for preparing drugs used to treat various tumor diseases through the screening study of in vivo and in vitro anti-tumor experimental models.
Owner:XINJIANG HUASHIDAN PHARMA RES
Quantitative Calculation Method of Paleobathy for Lacustrine Sediments
ActiveCN104932031BSimple and fast operationImprove ancient water depth restoration methodsGeological measurementsDepth planeProcess study
The present invention provides a method for quantitative calculation of paleo-depth for lacustrine deposition, the method for quantitative calculation of paleo-depth for lacustrine deposition includes: step 1, screening lakes similar to the research area; step 2, for the screened lakes, establishing Quantitative relationship between lake bottom sediment TOC and water depth; step 3, conduct mudstone TOC test for the research area, and count the stratum thickness of the target layer; step 4, establish the quantitative relationship between ancient water depth data and stratum thickness; and step 5, draw ancient Plane distribution of water depth. The paleo-depth quantitative calculation method for lacustrine sediments further improves the means of paleo-depth restoration, and provides new research ideas and technical means for the study of paleo-lake sedimentary evolution process and the prediction of multi-type lacustrine sand bodies.
Owner:CHINA PETROLEUM & CHEM CORP +1
A kind of specific primer, kit and identification method for identifying traditional Chinese medicine gecko
ActiveCN106868194BThe identification result is accurateSmall molecular weightMicrobiological testing/measurementDNA/RNA fragmentationAdulterantGecko
The invention provides a specific primer, a kit and an identification method for identifying traditional Chinese medicine kwangsi gecko. A lot of primers are designed based on a CYTB gene of the kwangsi gecko; the primer with species specificity is screened out through the screening study of a large amount of primers; the primer is used for identifying the traditional Chinese medicine kwangsi gecko, so that the kwangsi gecko medicinal material can be accurately separated from other adulterants, a PCR (Polymerase Chain Reaction) amplification product is only 100 to 250bp, the molecular weight is low, a lot of traditional Chinese medicine kwangsi gecko is ensured to be identified within a short time, and an identification result is accurate, stable, reliable and high in sensitivity.
Owner:BEIJING JIANSHENG PHARMA
Preparation method of physostigmine derivatives with resistance to activity of senile dementia disease
InactiveCN102114016AShort synthetic routeOrganic active ingredientsNervous disorderNatural productOrganic synthesis
The invention belongs to the field of organic synthesis and pharmaceutical chemistry and relates to synthetic derivatives of a natural product, namely physostigmine, as shown in a chemical structural formula 2, which have the activity of inhibiting acetylcholinesterase. In addition, the invention further relates to a preparation method of physostigmine derivatives 2, and the structure of the derivatives is basically characterized by enabling indole 5-bit to have 1,2,3-triazole substituent. The preparation method has the advantages of being short in synthetic routes, and being economic and efficient. The in vitro activity screening study shows that part of the newly synthesized physostigmine derivatives have strong activity of inhibiting the acetylcholinesterase, and are candidate medicaments with potential clinical application prospect for preventing senile dementia disease.
Owner:SICHUAN UNIV
Rotor magnetic ring of high-efficiency micro-motor and preparation method thereof
ActiveCN104333156BHigh strengthSmall water absorptionMagnetic circuit rotating partsMagnetic circuit characterised by magnetic materialsEngineeringScreening study
Owner:JIANGSU LEILI MOTOR
A kind of gynecological regulating menstruation sustained-release dropping pill and preparation method thereof
ActiveCN106466396BFully extractedGood sustained release effectPharmaceutical delivery mechanismPharmaceutical non-active ingredientsMedicinal herbsCellulose
The invention provides a kind of Gynecology Tiaojing Sustained Release Dropping Pill and its preparation method. By optimizing the extraction process of the original medicinal material and adopting the double extraction method of alcohol extraction and water extraction, the active components of the Chinese medicinal material can be extracted more fully. At the same time, in order to overcome the The defects of the prior art, through a large number of tests and screening studies, use ethyl cellulose compounded with carbomer with good biodegradability and good sustained release effect as the skeleton material, and then add an appropriate amount of polyethylene glycol to make a slow release agent. Release drop pill preparation, its product not only has stable quality, can reduce the number of times of taking medicine, but also can maintain blood drug concentration stable and enhance its drug effect.
Owner:GUIZHOU YIBAI WOMAN BIG PHARMA FACTORY
Anti-fungal-infection pharmaceutical composition and use thereof
ActiveCN111297856AEnhanced inhibitory effectReduce the amount of active ingredientsAntimycoticsOrganic chemistryAntifungal drugItraconazole
The invention belongs to the technical field of drugs, and particularly relates to a anti-fungal-infection pharmaceutical composition and use thereof. An alkaloid compound of a formula (I) has the useof anti-fungal infections, and a new candidate drug is provided for the treatment of fungal infections. In addition, it is further found that the combined use of the compound of the formula (I) and itraconazole has a synergistic antifungal effect through a combined drug experiment, while the amount of active ingredients of the drug is reduced, the drug resistance of microorganisms and the human side effects are reduced, and a foundation is further laid for the screening research of novel antifungal drugs.
Owner:HEILONGJIANG UNIV OF CHINESE MEDICINE