Anti-parasitic ivermectin transdermal solution used for livestock and preparation method thereof

An ivermectin and anti-parasitic technology, which is applied in the field of anti-parasitic ivermectin transdermal solution for livestock and its preparation, can solve the problems of decreased feed utilization rate, reduced feed utilization rate, and slow growth of livestock , to achieve the effect of reducing inter-individual differences, reducing decomposition rate, and increasing percutaneous absorption

Inactive Publication Date: 2009-11-18
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The harm of parasites to livestock is mainly through the consumption of nutrients in livestock, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for livestock, resulting in slow growth and reduced feed utilization.
At prese

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of anti-parasitic ivermectin transdermal solution for livestock, its constituents and parts by weight thereof are respectively (by every 100ml proportioning of raw and auxiliary materials, the following examples are the same):

[0026] Ivermectin 0.5g

[0027] Ethyl acetate 10ml

[0028] Dimethyl sulfoxide 25ml

[0029] Azone 4ml

[0030] Isopropanol 2ml

[0031] Propylene Glycol 59ml.

[0032] The crude drug of the ivermectin transdermal solution involved in the present invention is ivermectin, and its alias is: 22,23-dihydroabamectin.

[0033] A method for preparing an anti-parasitic ivermectin transdermal solution for livestock, comprising the steps of:

[0034] (1) get the ivermectin of prescription quantity and dissolve to dissolve with ethyl acetate, obtain ivermectin solution;

[0035] (2) add dimethyl sulfoxide, isopropanol, azone while stirring in the above-mentioned ivermectin according to the prescription amount, and mix well;

[0036] (3) After...

Embodiment 2

[0040] An animal anti-parasitic ivermectin transdermal solution, its constituents and parts by weight are respectively:

[0041] Ivermectin 0.5g

[0042] Ethyl acetate 10ml

[0043] Dimethyl sulfoxide 25ml

[0044] Azone 4ml

[0045] Isopropanol 2ml

[0046] Propylene glycol 59ml

[0047] The steps of the preparation method of this embodiment are the same as those in Example 1.

Embodiment 3

[0049] An animal anti-parasitic ivermectin transdermal solution, its constituents and parts by weight are respectively:

[0050] Ivermectin 0.5g

[0051] Ethyl acetate 10ml

[0052] Dimethyl sulfoxide 30ml

[0053] Azone 5ml

[0054] Isopropanol 2ml

[0055] Propylene glycol 53ml

[0056] The steps of the preparation method of this embodiment are the same as those in Example 1.

[0057] Test data: after 8 hours of administration of azone and dimethyl sulfoxide in the drug formula, the penetration rate reaches 90.5%, exceeding the standard penetration rate.

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Abstract

The invention relates to an anti-parasitic ivermectin transdermal solution used for livestock and a preparation method thereof. The anti-parasitic ivermectin transdermal solution comprises the following components respectively according to parts by volume: 5 to 15 parts of ethyl acetate, 20 to 30 parts of dimethyl sulfoxide, 2 to 6 parts of azone, 1 to 3 parts of isopropanol and 50 to 70 parts of propanediol; and the content of ivermectin is 0.3g to 1g in a solution of 100ml, and the finished product is prepared by the processes of dissolving, mixing, filtering and filling. The azone related in the prescription of the invention is a novel skin penetration enhancer, can increase the transdermal absorption of the skin to various medicines of different types, effectively avoids the pass effect of hepar, avoids peak and valley phenomena in the absorption process of the medicine, reduces the toxic or side effect caused by the correlative dosage in the medicine, prolongs the effective effect time, changes the administration area, effectively regulates the administration dosage and reduces differences among individuals. The invention has the characteristic of simple, convenient and fast use, and is more suitable for the anti-parasitic prevention and treatment of a pasturing area compared with other preparation forms.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to an anti-parasitic ivermectin transdermal solution for livestock and a preparation method thereof. Background technique [0002] Transdermal preparation is a new dosage form of transdermal administration, that is, the drug enters the whole body through the capillary of the skin and reaches the effective blood drug concentration through the blood circulation. Compared with transdermal preparations, it has the advantages of avoiding side effects caused by oral administration and gastrointestinal administration, such as hepatic effect and gastrointestinal inactivation, maintaining a constant blood concentration, and prolonging the effective time of action. [0003] The harm of parasites to livestock is mainly through the consumption of nutrients in livestock, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for livestock, result...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7048A61K47/22A61P33/00
Inventor 要瑞丽刘爱华赵树强付永利
Owner TIANJIN BIJIA PHARMA CO LTD
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