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Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof

An anti-parasitic and disintegrating tablet technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, anti-infectives, etc., can solve the problem of dogs and cats who have difficulty swallowing and do not want to take medicine, and dogs and cats who spit out , Containing for a long time and other problems, to achieve the effect of improving bioavailability, speeding up absorption and reducing pain

Inactive Publication Date: 2014-04-30
LIAOCHENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the insect repellent tablets on the market are ordinary tablets. Because ordinary tablets are hard and take a long time in the oral cavity, dogs and cats often have difficulty swallowing and are unwilling to take the medicine, and are often spit out by dogs and cats.

Method used

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  • Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof
  • Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof
  • Anti-parasitic orally disintegrating tablet for dogs and cats and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] An anti-parasitic orally disintegrating tablet for dogs and cats, the prescription of the orally disintegrating tablet is based on 1000 tablets of medicine, each tablet weighs 200 mg, a total of 200 g, wherein:

[0020]

[0021]

[0022] An anti-parasitic orally disintegrating tablet for dogs and cats, its preparation method comprises the following steps: (1) raw materials ivermectin, albimazole, crospovidone, microcrystalline cellulose, mannitol, lactose and meat-flavored essence, pass through a 100-mesh sieve respectively for later use, weigh the corresponding quantity according to the formula quantity, and mix them uniformly sequentially in an equal increasing manner.

[0023] (2) Dissolve sodium lauryl sulfate and acesulfame potassium in water, then spray the prepared aqueous solution into the above drug powder, stir quickly, mix evenly to make a soft material, granulate through a 18-mesh sieve, and dry at 60°C , passed through a 20-mesh sieve for granulation;...

Embodiment 2

[0026] An anti-parasitic orally disintegrating tablet for dogs and cats, the prescription of the orally disintegrating tablet is based on 1000 tablets of medicine, each tablet weighs 200 mg, a total of 200 g, wherein:

[0027]

[0028]

[0029] Preparation:

[0030] (1) Pass the raw materials ivermectin, albendazole, crospovidone, microcrystalline cellulose, mannitol, lactose and meat flavor respectively through a 100-mesh sieve for later use, and weigh the corresponding quantity according to the formula , using the method of equal increments to mix uniformly in turn.

[0031] (2) Dissolve sodium lauryl sulfate and acesulfame potassium in water, then spray the prepared aqueous solution into the above drug powder, stir quickly, mix evenly to make a soft material, granulate through a 18-mesh sieve, and dry at 60°C , passed through a 20-mesh sieve for granulation;

[0032] (3) Add micropowder silica gel and magnesium stearate to the above granules, mix well and then compr...

Embodiment 3

[0034] An anti-parasitic orally disintegrating tablet for dogs and cats, the prescription of the orally disintegrating tablet is based on 1000 tablets of medicine, each tablet weighs 200 mg, a total of 200 g, wherein:

[0035]

[0036]

[0037] Preparation:

[0038] (1) Pass the raw materials ivermectin, albendazole, crospovidone, microcrystalline cellulose, mannitol, lactose and meat flavor respectively through a 100-mesh sieve for later use, and weigh the corresponding quantity according to the formula , using the method of equal increments to mix uniformly in turn.

[0039] (2) Dissolve sodium lauryl sulfate and acesulfame potassium in water, then spray the prepared aqueous solution into the above drug powder, stir quickly, mix evenly to make a soft material, granulate through a 18-mesh sieve, and dry at 60°C , passed through a 20-mesh sieve for granulation;

[0040] (3) Add micropowder silica gel and magnesium stearate to the above granules, mix well and then compr...

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Abstract

The invention relates to an anti-parasitic orally disintegrating tablet for dogs and cats and a preparation method thereof and belongs to the field of veterinary preparations. The formula of the anti-parasitic orally disintegrating tablet provided by the invention comprises the following components in parts by weight: 0.1-2 parts of ivermectin, 30-60 parts of albendazole, 20-30 parts of disintegrant, 15-40 parts of filler, 1-2 parts of lubricant, 1-5 parts of glidant, 1-4 parts of surfactant and 1-4 parts of flavoring agent. The ivermectin and the albendazole are matched to prepare the orally disintegrating tablet, and the anti-parasitic orally disintegrating tablet has the advantages of simple production process, stable dosage and high production efficiency; and simultaneously, the flavoring agent is added into the orally disintegrating tablet, so that the taste of the medicament is improved, the medicament has the beef flavor, the palatability is increased, the compliance in medicament delivery of the dogs and the cats is further improved, and the anti-parasitic orally disintegrating tablet further has the advantages of more convenience in administration, fast disintegration after entering the mouth, higher bioavailability, good insect-dispelling effect in clinical use and broad application prospects.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to an anti-parasitic orally disintegrating tablet for dogs and cats and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, more and more pet dogs and cats are kept. Pets can not only bring fun to the ordinary life of animal owners, but also serve as a spiritual sustenance to relieve the loneliness of animal owners. and stress. However, internal and external parasitic diseases of pet dogs and cats are very common diseases, which seriously endanger the health of pet dogs and cats. Ivermectin is currently recognized as a broad-spectrum, high-efficiency, low-toxicity, low-residue macrolide antiparasitic drug. It has special curative effects, but it is not effective against tapeworms and trematodes. Altimazole is a broad-spectrum anthelmintic with high efficiency and low toxicity, and has a good anthelmintic effect...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/20A61K47/46A61K47/38A61P33/00A61K31/4184
Inventor 苏建青褚秀玲
Owner LIAOCHENG UNIV
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