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Dog and cat dropping pill preparation containing feed attractant

A food-attractant and dripping pill technology, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pill delivery, can solve problems such as difficulty in administration and achieve excellent food-attracting effects

Inactive Publication Date: 2017-12-26
中农华威生物制药(湖北)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention proposes a drop pill preparation for dogs and cats containing therapeutic drugs and food attractants and a preparation method thereof. The drop pill preparation prepared by this method has excellent food-attracting effect, and overcomes the problem of dogs and cats already on the market. Drawbacks of difficult administration with oral formulations

Method used

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  • Dog and cat dropping pill preparation containing feed attractant
  • Dog and cat dropping pill preparation containing feed attractant
  • Dog and cat dropping pill preparation containing feed attractant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, composition and preparation of drop pill preparation 1 to preparation 6 containing praziquantel

[0029] Each component and content contained in drop pill preparation 1 to preparation 6 are shown in Table 1.

[0030] Formulations 1 to 6 described in Table 1 were prepared with a homemade laboratory drop pill apparatus. The dropping pill device for the laboratory is composed of a liquid medicine bottle with a water circulation interlayer, a straight condenser tube, a condensation bottle with a water circulation interlayer and other main components. The temperature of the circulating water is controlled by a constant temperature water bath and a low temperature circulating water tank. Concrete preparation comprises the following steps:

[0031] Control the dripping pill liquid at 75-92°C (contained in a interlayered liquid bottle), adjust the weight of the dropping pill by changing the diameter of the drop opening and the dropping speed, and manually control...

Embodiment 2

[0035] Embodiment 2, composition and preparation of drop pill preparation 7 to drop pill preparation 9

[0036] Dropping pill preparations 7 to 9 are drop pills with a coating layer structure, and the active ingredient is praziquantel. Praziquantel is a typical antiparasitic drug with special odor and bitter taste, and dogs are very sensitive and disgusted by it. In the oral preparation containing praziquantel, if a large amount of dog-favored food attractant is not added or the preparation is coated, the active feeding rate of the dog is almost zero, even if it is put into the dog's mouth, it will be eaten by the dog spit out. Therefore, the present invention proposes that the dropping pills are further coated with a coating material to achieve a more ideal taste-masking effect. In this embodiment, the dropping pills prepared by the dropping pill machine are called pill cores, and the coated pill cores are called dropping pill preparations.

[0037] The compositions of for...

Embodiment 3

[0042] Embodiment 3, dog to the test of the active feeding rate of preparation 1 to preparation 9 and contrast preparation

[0043] Comparative preparation 1: the composition of comparative preparation 1 does not contain food attractant (mutton fat and suet residue), and other ingredients are the same as preparation 3 in Example 1, the amount of lacking food attractant (mutton fat and suet residue) Substitute the same amount of glyceryl monostearate. Its preparation method is the same as Formulation 3.

[0044] Contrast preparation 2: do not contain pig liver powder in the ball core of contrast preparation 2, do not contain suet and suet residue in the coating material, other ingredients are the same as the preparation 7 in the embodiment 2, the amount of the food-inducing agent that lacks ( Pork liver powder, sheep oil and suet residue) are replaced with the same amount of sucrose. It was prepared in the same manner as Formulation 7.

[0045] Comparative preparation 3: it ...

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Abstract

The invention provides a dog and cat dropping pill preparation containing a feed attractant and treatment drugs (anti-parasite drugs, antibacterial drugs, non-steroidal anti-inflammatory drugs). The dropping pill preparation has excellent feeding attraction effect. In the dropping pill preparation, the feed attractant accounts for 5-55% of the weight of the dropping pill, the treatment drugs account for 0.1-35% of the weight of the dropping pill, and the matrix content at least accounts for 10% of the weight of the dropping pill. The treatment drugs contained in dropping pill can be combined with a capsule wall material and prepared into a microcapsule, and exist in the dropping pill in a microcapsule state. The capsule wall material for preparation of the microcapsule is selected from at least one of polyvinylpyrrolidone, acrylic resin, gelatin and Arabic gum. The feed attractant composing the dropping pill includes at least one of mutton tallow, mutton tallow residue, beef tallow, beef tallow residue, pork liver powder, chicken liver powder, fish meal, beef powder, chicken powder, natural bacon baking powder, and ham baking powder.

Description

technical field [0001] The present invention relates to preparation technology of veterinary medicine, in particular to a drop pill preparation containing food attractant and therapeutic drug (antiparasitic drug, antibacterial drug, non-steroidal anti-inflammatory drug), which is a kind of drug with good food attracting effect. preparations for dogs and cats. Background technique [0002] The commercially available preparations commonly used for the prevention and treatment of diseases in dogs and cats include tablets, injections and external preparations (such as pouring agents, liniments and preparations for driving and killing ectoparasites by medicated baths). The most commonly used dosage forms are mainly oral tablets. Because most medicines have certain odor, bitter taste and dog's sense of smell is extremely sensitive, therefore, currently commercially available oral tablets for dogs (such as tablets containing praziquantel, tablets containing ivermectin, tablets con...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61K47/46A61K45/00A61K31/4985A61K31/365A61K31/7048A61P33/10A61P33/14
Inventor 游锡火王玉万翁志飞王金萍韩可可任雅楠沈力李莹李蕾
Owner 中农华威生物制药(湖北)有限公司
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