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Veterinary anti-parasitic preparation containing carnauba wax

An anti-parasitic and brazilian wax technology, applied in the field of veterinary drug preparation preparation, can solve the problem that the clinical effect of the preparation technical scheme is not disclosed or clearly discussed, etc.

Active Publication Date: 2015-06-03
中农华威制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also some patents (such as: patents CN1572302A, CN1698637A, CN1236758A, CN1461640A, CN1444925A, CN1421199A, CN1572300A) have mentioned that the slow release material or suspending agent etc. that can use Brazilian wax as injection, but for specific preparation technical scheme (such as formula Composition, etc.) and its core content such as clinical effects are not publicly or clearly discussed

Method used

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  • Veterinary anti-parasitic preparation containing carnauba wax
  • Veterinary anti-parasitic preparation containing carnauba wax
  • Veterinary anti-parasitic preparation containing carnauba wax

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, the influence of the presence of GMO in the Brazil wax concentration and preparation on the oil agent adhesion rate (%)

[0020]Oil agent 1 to oil agent 7 in the table take soybean oil as dispersion medium and add to the final volume of oil agent with soybean oil, avermectin concentration (%), carnauba wax concentration (%), GMO concentration (%) in oil agent , are all weight / volume percentage concentrations; The mensuration of oil agent adhesion rate is carried out by the method described in the summary of the invention above, and in the following table, adhesion rate (%) is the average value of 3 parallel samples, and measuring temperature is room temperature (21 -24°C).

[0021]

[0022] The preparation process of above oil agent 1 to oil agent 7 is as follows:

[0023] Mix Brazilian wax and soybean oil, and dissolve Brazilian wax at 85-90°C to obtain a transparent oil solution. After cooling down to room temperature, add abamectin and GMO (oil agen...

Embodiment 2

[0025] Example 2: Detection of blood drug concentration after injecting sheep with oil 1, oil 2, oil 3 and comparison preparations in Example 1.

[0026] (1) preparation of contrast preparation: take purity as 96% (B 1a content) of abamectin 5.21g, mixed with 497ml soybean oil, with a high-speed shearing type homogenizer under the condition of 12000-16000r / min, repeated shearing for 1 hour, to obtain a comparison containing 1% abamectin preparation.

[0027] (2) Experimental animals, drug administration and blood sample collection: Select 20 healthy sheep (small-tailed Han sheep) with a body weight of 38-45 kg, and divide them into 4 groups at random, with 5 animals in each group, numbered respectively as group 1, group 2, and group 3. Group 4, group 1 neck subcutaneous injection of contrast preparation 0.4mg / kg b.w., group 2, group 3, group 4 injection of oil 1, oil 2, oil 3 in Example 1 respectively, neck subcutaneous injection , the dosage is 0.4mg / kg b.w. After administ...

Embodiment 3

[0033] Embodiment 3, the detection of blood drug concentration after injecting the oil agent 2, the oil agent 4, and the oil agent 6 in the embodiment 1 in the sheep.

[0034] (1) Test animals, drug administration and blood sample collection: select 15 healthy sheep (small-tailed Han sheep) with a body weight of about 40 kilograms, and divide them into 3 groups at random, with 5 animals in each group, and subcutaneously inject the sheep in Example 1 in the neck respectively. Oil 2, oil 4, oil 6, the doses are all 0.4mg / kg b.w. After administration, blood was collected from the jugular vein of sheep on time, accurately 4ml each time, and the blood samples collected at the same time in the same test group were put into the same 20ml centrifuge tube containing heparin sodium, mixed and centrifuged at 3000r / min for 10min, and the upper layer was taken Liquid (plasma), stored at -18 to -20°C.

[0035] (2) Blood sample processing and detection of abamectin in plasma: the method of ...

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Abstract

The invention relates to a veterinary anti-parasitic injection containing carnauba wax. The preparation is mainly prepared from anti-parasitic medicine, the carnauba wax and an oily medium, wherein the anti-parasitic medicine is avermectins, praziquantel and oxfendazole; the oily medium is vegetable oil, ethyl oleate or benzyl benzoate, and more than one of the vegetable oil, ethyl oleate or benzyl benzoate can be combined to use. Glycerol mono-oleate can be added in the preparation, the carnauba wax and the glycerol mono-oleate are compositely applied, and the slow-release effect of the preparation is better. The selected preparation is prepared from 36-80 g of abamectin anti-parasitic medicine, 10-70 g of the carnauba wax, 80-120 g of the glycerol mono-oleate, 0.1-0.3 g of an antioxidant, 10-20 g of benzyl alcohol and the balance of the oily medium (per 1000ml).

Description

technical field [0001] The invention belongs to the preparation technology of veterinary drug preparations, and in particular relates to the preparation of long-acting veterinary injections containing antiparasitic drugs by using Brazilian wax or Brazilian wax and glycerol monooleate as slow-release materials. Background technique [0002] Carnauba wax, also known as carnauba wax, is non-toxic, non-irritating, and is recognized as a safe pharmaceutical excipient. It is often used as a polishing agent for tablet or pill coating, ointment base, suppository base, and solid dispersion in pharmaceuticals. Dispersion medium for body and sustained release material for oral preparation. There are not many reports about the application of Brazilian wax in injections. Patent CN86105087C discloses a technical scheme for preparing a long-acting injection containing bovine growth hormone. The bovine growth hormone is suspended in an oily medium composed of Brazilian wax and vegetable oi...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K47/44A61K47/14A61K45/00A61K31/4985A61K31/4184A61K31/7048A61P33/00
Inventor 王玉万戴晓曦任雅楠翁志飞李蕾李莹潘贞德沈力
Owner 中农华威制药股份有限公司
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