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Ivermectin nanoemulsion antiparasitic medicine and preparation method thereof

An ivermectin and anti-parasitic technology, applied in the field of ivermectin nanoemulsion antiparasitic drugs and preparation thereof, can solve problems such as no research reports on ivermectin nanoemulsion injection, and achieve improved Bioavailability, simple method and process, solving the effect of low solubility

Inactive Publication Date: 2014-12-17
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Ivermectin nanoemulsion antiparasitic medicine and preparation method thereof
  • Ivermectin nanoemulsion antiparasitic medicine and preparation method thereof
  • Ivermectin nanoemulsion antiparasitic medicine and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] An ivermectin nanoemulsion antiparasitic drug is composed of the following raw materials in mass percentage:

[0035] Ivermectin 2.5g,

[0036] TX-10 53.00g,

[0037] PEG400 27.00g,

[0038] Isopropyl myristate 20.00g,

[0039] 50g of distilled water.

[0040] Its preparation method is:

[0041] Mix 53.00gTX-10 and 27.00gPEG400 evenly;

[0042] 20.00g isopropyl myristate was added to step 1) and mixed evenly;

[0043] Then completely dissolve the ivermectin of 2.5g and join in the solution prepared in step 2) and stir evenly;

[0044] Slowly add 50.00 g of distilled water dropwise to the liquid prepared in step 3) at 37°C, and keep stirring while adding dropwise, until a uniform and transparent system is formed.

[0045] Such as figure 1 It is the particle size distribution figure of the present embodiment ivermectin nanoemulsion, and horizontal axis represents particle size, and vertical axis represents particle size distribution, shows that the mean particle d...

Embodiment 2

[0048] An ivermectin nanoemulsion antiparasitic drug is composed of the following raw materials in mass percentage:

[0049]

[0050] The preparation method is the same as in Example 1.

Embodiment 3

[0052] An ivermectin nanoemulsion antiparasitic drug is composed of the following raw materials in mass percentage:

[0053]

[0054] The preparation method is the same as in Example 1.

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Abstract

The invention discloses an ivermectin nanoemulsion antiparasitic medicine and a preparation method thereof. A particle size range of the nanoemulsion is 1-100nm and the nanoemulsion comprises the following raw materials in percentage by mass: 0.10-1.00% of ivermectin, 1.00-20.00% of cosurfactant, 10.00-20.00% of surfactant, 1.00-5.00% of oil phase and the balance being distilled water. The nanoemulsion disclosed by the invention is a colorless, clear and transparent liquid in appearance, and has characteristics of low viscosity, good stability, strong dispersion, high absorption speed and targeted medicine release; in addition, the dissolubility and bioavailability of the medicines are improved and toxic and side effects are reduced. The nanoemulsion can take a good expelling and killing effect on in vitro and vivo parasites, particularly on nematode and arthropod, and can effectively prevent and treat parasitic diseases of animals within a wide spectrum.

Description

technical field [0001] The invention belongs to the field of veterinary medicine and relates to a medicine for preventing and treating animal parasitic diseases, in particular to an ivermectin nanoemulsion antiparasitic medicine and a preparation method thereof. Background technique [0002] Ivermectin (Ivermectin, IVM) is a derivative of abamectin, and it is an excellent broad-spectrum antiparasitic drug in the world. Its main component is 22,23-dihydroabamectin Bla. IVM has the advantages of broad spectrum, high efficiency, small dosage and safety, etc. It has high-efficiency repellent and killing effects on internal and external parasites, especially nematodes and arthropods. However, IVM is almost insoluble in water, which seriously restricts the use of this type of drug. [0003] At present, although ivermectin has been made into conventional dosage forms such as premixes, tablets, ointments, solutions, injections, and transdermal agents, and new dosage forms such as s...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/7048A61P33/00
Inventor 唐亚雄王泽洲陈雨文魏枭
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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