17 results about "Nitazoxanide" patented technology

The invention relates to the technical field of agricultural protection, in particular to an amide thiazole compound as well as a preparation method and application thereof. The amide nitrothiazole compound shown in the formula (1) is provided by carrying out proper structural modification on nitazoxanide, and the compound has good biological activity, can be applied to prevention and treatment of cryptosporidiosis and has a certain inhibition effect on florae such as rice streak, rice bacterial leaf blight, rice ralstonia solanacearum, cabbage soft rot and citrus ulcer. Formula (1): # imgabs0 #

The present invention provides an aminonitrothiazole derivative for use in the preparation of a drug for preventing and treating viral infections and related diseases caused thereto, and belongs to the field of pharmaceuticals. The structure of the aminonitrothiazole derivative is shown in Formula I. Experimental results show that the compound can effectively inhibit the activity of respiratory syncytial virus, enterovirus 71, and the new coronavirus, and the inhibitory effect is better than that of the positive controls nitazoxanide and lauric acid. The compound provided by the present invention can be used to prepare a drug for preventing and / or treating viral infections, and can be used to prepare a drug for preventing and / or treating related diseases caused by viruses, and has broad application prospects.

The application provides a use of a nitrothiazole derivative in preparation of an antibacterial agent for inhibiting helicobacter pylori, and belongs to the field of pharmacy.The structure of the amino nitrothiazole derivative is shown as formula I.The experimental results show that the compound can effectively inhibit the growth of helicobacter pylori, and the inhibiting effect is better than that of control compounds nitazoxanide and lauric acid; the compound can effectively treat mice infected with helicobacter pylori, clear helicobacter pylori in the stomach and reduce the inflammatory response of the stomach tissue, and the treatment effect is better than that of control compounds nitazoxanide and lauric acid.The compound provided by the application can be used for preparing the antibacterial agent for inhibiting helicobacter pylori, and can be used for preparing a medicine for preventing and / or treating helicobacter pylori infection and related diseases caused by the helicobacter pylori, and has a wide application prospect.

A combination comprising tilorone / nelfinavir; tilorone / molnupinavir; tilorone / remdesivir; tilorone / alfacalcidol: tilorone / clofazimine; tilorone / danazol; tilorone / manidipine; tilorone / sertraline; tilorone / trifluoperazine; remdesivir / hexachlorophene; remdesivir / mycophenolate; mycophenolate / hexachlorophene; mycophenolate / nelfinavir; or mycophenolate / nitazoxanide. This combination can be used for blocking the replication of a coronavirus in a coronavirus-infected cell, for treating an infection by a coronavirus in a subject, for treating a coronavirus-related disease in a subject, and / or for reducing the risk of developing a coronavirus-related disease or the severity of a coronavirus-related disease in a subject.

The invention relates to a nano drug delivery system loaded with nitazoxanide as well as a preparation method and application of the nano drug delivery system, and belongs to the technical field of pharmaceutical preparations. The nano drug delivery system is prepared by loading nitazoxanide on a metal organic framework ZIF-90 nano material through a simple and rapid method. The nano drug delivery system constructed by the invention can effectively improve the solubility and stability of nitazoxanide, and realizes the enrichment of drugs in tumor cell mitochondria by virtue of the mitochondrial targeting characteristic of the ZIF-90 material. The system can intelligently release drugs under the acidic and high ATP conditions of a tumor microenvironment, not only utilizes the metabolic reprogramming effect induced by nitazoxanide, but also synergistically enhances the anti-tumor effect in cooperation with the Zn < 2 + >-triggered oxidative stress disorder dual mechanism, and provides a new strategy for solving the problems of low bioavailability, poor targeting property and the like in clinical application of nitazoxanide.

Compounds and pharmaceutical compositions effective for treating cognitive disorders are described. The compounds and pharmaceutical compositions described include Nitazoxanide (NTZ), Nitazoxanide (NTZ) analogs, Nitazoxanide (NTZ) metabolites, or Nitazoxanide (NTZ) metabolite analogs. Methods of treating, ameliorating, and / or preventing cognitive disorders using the compounds and pharmaceutical compositions disclosed herein are also described.

The present invention relates to a composition for use in a method of treating a liver disease, preferably metabolic dysfunction-associated steatohepatitis (MASH). The composition comprises: • An effective amount of at least one saponin active ingredient (preferably ginsenoside or diosgenin) • And / or an effective amount of at least one anthelmintic (preferably niclosamide or nitazoxanide) • And / or an effective amount of at least one mitochondrial uncoupler.

The present application relates to the technical field of medicine, in particular to a potential genotoxic impurity in a morpholine nitroimidazole raw material and preparation and a preparation method and application thereof.The potential genotoxic impurity is 2-methyl-5-nitro-1-nitrosoimidazole.A new structure compound 2-methyl-5-nitro-1-nitrosoimidazole of diazoles is found in the synthesis process of the morpholine nitroimidazole raw material for the first time.The compound is identified as a potential genotoxic impurity because of containing a nitrosamine warning structure.A method for analyzing the potential genotoxic impurity 2-methyl-5-nitro-1-nitrosoimidazole by using ultra-high performance liquid chromatography-mass spectrometry is established for the first time, which is of great significance to the quality control of the morpholine nitroimidazole raw material and preparation.The detection method provides a reference for the quality evaluation of other starting materials, intermediates and raw materials that can produce 2-methyl-5-nitro-1-nitrosoimidazole.

The present invention relates to a compound selected from the group consisting of nitazoxanide, tizoxanide, tezoxanide glucuronate, and pharmaceutically acceptable salts thereof, for use in a method of treating liver injury.

The present invention pertains to a composition for use in a method of treating a liver disease, preferably metabolic dysfunction-associated steatohepatitis (MASH), the composition comprising an effective amount of at least one saponin agent, preferably ginsenoside or diosgenin, and / or an effective amount of at least one anthelmintic agent, preferably niclosamide or nitazoxanide and / or an effective amount of at least one mitochondrial uncoupling agent.

The invention relates to the technical field of medicine, in particular to application of nitazoxanide and pharmaceutically acceptable salt thereof in preparation of a medicine for resisting glazing cell type craniopharyngeal tubuloma. The invention provides application of nitazoxanide and pharmaceutically acceptable salt thereof in preparation of a medicine for resisting glazing cell type craniopharyngeal tubuloma. The nitazoxanide and the pharmaceutically acceptable salt thereof can inhibit proliferation and clone formation ability of glazed cell type craniopharyngeal tubuloma organs by promoting degradation of beta-catenin, and are targeted drugs capable of effectively preventing a beta-catenin activation pathway. The pharmaceutical composition has a good treatment effect and application prospect on the glazed cell type craniopharyngeal tubuloma, and solves the problem of lack of targeted drugs for treating the glazed cell type craniopharyngeal tubuloma.

The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. The invention explores readily available starting materials with reaction conditions that ar

The application discloses a kit for rapidly detecting bacterial energy metabolism and a preparation method and application thereof, and belongs to the technical field of microorganism analysis, drug screening and detection. The kit comprises reaction premixed powder, anaerobic reaction liquid and optional positive control; the reaction premixed powder comprises the following components in parts by weight: 1 part of benzyl viologen; 0.43-0.64 parts of sodium pyruvate; 0.054-0.082 parts of coenzyme A; 0.037-0.055 parts of MgCl2.7H2O; the anaerobic reaction liquid is a buffer solution containing sodium sulfide-9 hydrate; and the positive control is nitazoxanide or glychalcone A. The application further discloses a preparation method and application of the kit, and the application comprises the following steps: rapidly detecting bacterial energy metabolism activity; and / or screening substances for inhibiting bacterial energy metabolism. The kit can rapidly, sensitively and at low cost evaluate the physiological activity of bacteria, and can also be used for rapidly screening and evaluating anaerobic microorganism energy metabolism inhibitors.

The invention relates to the technical field of agricultural protection, in particular to a cyclamine urea-containing thiazole compound as well as a preparation method and application thereof. The cyclamine urea-containing thiazole compound provided by the invention is a compound as shown in a formula (1), the drug solubility is improved by prolonging a carbon chain structure among nitazoxanide molecules, the activity of the compound is further improved, drug molecules of an azacycloalkane structure have good insecticidal and bacteriostatic effects, the two active molecule fragments are spliced, and the compound has good insecticidal and bacteriostatic effects. The purposes of optimizing the medicine structure and improving the biological activity can be achieved. Formula (1): # imgabs0 #

The present invention relates to novel uses of nitazoxanide, or analogues thereof.

The invention relates to a nitrothiazole compound containing a glycine fragment, and particularly discloses the nitrothiazole compound containing the glycine fragment as well as a preparation method and application of the nitrothiazole compound. The nitrothiazole compound containing the glycine fragment provided by the invention is a compound as shown in a formula (1), a glycine structure and a nitazoxanide drug molecule are spliced and designed, the glycine fragment is introduced into an amide part in nitazoxanide, a carbon chain structure is prolonged, molecular rigidity is reduced, and the solubility of the compound is improved; the activity of the nitrothiazole compound containing the glycine fragment is further improved. Formula (1): # imgabs0 #

The present disclosure relates to the technical field of medicines, and in particular relates to the use of nitazoxanide and a pharmaceutically acceptable salt thereof in the preparation of an anti-adamantinomatous craniopharyngioma drug. Provided in the present disclosure is the use of nitazoxanide and a pharmaceutically acceptable salt thereof in the preparation of an anti-adamantinomatous craniopharyngioma drug. Nitazoxanide and the pharmaceutically acceptable salt thereof are capable of inhibiting the proliferation and colony formation ability of adamantinomatous craniopharyngioma organoids by means of promoting the degradation of a β-catenin, are targeted drugs capable of effectively blocking an activation pathway of the β-catenin, have good therapeutic efficacy and application prospects for adamantinomatous craniopharyngioma, and solve the problem of lack of targeted drugs for treating adamantinomatous craniopharyngioma.