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3 results about "Atovaquone" patented technology
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Atovaquone is used to prevent or treat a serious lung infection called Pneumocystis pneumonia (PCP).
Mitochondria-targeted atovagone: a more potent and more effective antitumor, antimicrobial, and antimalarial drug
ActiveUS12594283B2Group 5/15 element organic compoundsPhosphorous compound active ingredientsAtovaquonePharmaceutical drug
The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
Owner:UNIV DAIX MARSEILLE +1
Phototherapy nano-drug with mitochondrion / STAT3 protein double-site targeting as well as preparation method and application of phototherapy nano-drug
The invention discloses a phototherapy nano-drug with mitochondrial / STAT3 protein double-site targeting. The phototherapy nano-drug is ATO / CR nano-particles formed by self-assembling a compound CR and atorvaquone under the action of distearoyl phosphatidyl ethanolamine-polyethylene glycol; the structure of the compound CR is shown as a formula I in the specification. The invention discloses an application of the phototherapy nano-drug with mitochondrial / STAT3 protein double-site targeting in preparation of drugs for treating tumors. The phototherapy nano-drug can target mitochondria and STAT3 protein in tumor cells through ATO, and can also passively target tumor sites through the high-permeability long-retention effect of nano-particles, so that more nano-therapeutic agents are enriched around tumors, and the curative effect is improved. The phototherapy nano-drug provided by the invention has good photothermal performance, can effectively enhance the PTT effect of gastric cancer, and exerts the tumor synergistic treatment ability by promoting cell apoptosis, inhibiting angiogenesis and hindering the cell cycle.
Owner:ANHUI MEDICAL UNIV
Mitochondria-targeted atovaquone: a more potent and more effective antitumor, antimicrobial, and antimalarial drug
PendingUS20260174785A1Group 5/15 element organic compoundsPhosphorous compound active ingredientsAntibiosisAtovaquone
The present invention provides novel mitochondria-targeted Atovaquone compounds (Mito-ATO), a mitochondria-targeted derivative of Atovaquone, and methods of using such compounds. Methods of treating cancer using mito-ATO are also provided. Methods of enhancing an anti-tumor immune response by administering mito-ATO are further provided.
Owner:MEDICAL COLLEGE OF WISCONSIN INC +1