An improved process for the preparation of nitazoxanide and intermediates thereof
A single-vessel process with specific solvents and precipitation techniques addresses the inefficiencies of existing Nitazoxanide synthesis, achieving high purity and cost-effectiveness for industrial-scale production.
GB2625684BActive Publication Date: 2026-06-11COUNCIL OF SCI & IND RES
Patent Information
- Application Number
- GB2024005057
- Authority / Receiving Office
- GB · GB
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2021-10-05
- Filing Date
- 2022-09-21
- Publication Date
- 2026-06-11
- Estimated Expiration
- 2042-09-21
AI Technical Summary
Technical Problem
Existing processes for synthesizing Nitazoxanide are labor-intensive, time-consuming, and not suitable for industrial-scale production, leading to low purity and high manufacturing costs, and involve the use of reagents that form impurities.
Method used
A single-vessel process using specific reaction solvents and precipitation/crystallization techniques to synthesize Nitazoxanide, avoiding column chromatography and utilizing starting materials like 1,1-dimethoxy-N,N-dimethylethanolamine, brominating agents, and acid catalysts to produce high-purity intermediates.
Benefits of technology
The process achieves high chemical purity and scalability, reducing costs and time, making it industrially viable for Nitazoxanide production.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to the process for the preparation of Nitazoxanide and intermediates thereof. The invention explores readily available starting materials with reaction conditions that ar
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Citation Information
Patent Citations
CN001935796A
Preparation method of nitazoxanide
CN101602744B
Method for preparing nitazoxanide
CN103159697A
One-step synthesis method of nitazoxanid
CN104447613A
Preparation method of nitazoxanide
CN105175352A