8 results about "Imidaclothiz" patented technology

The present invention relates to combinations of a compound of formula (A-1) with a compound selected from the group consisting of dimpropyridaz, emamectin and isocycloseram, bentioflumin, pioxaniliprole, isoflualanam, cybenzoxasulfyl, vinylfluthrin, cyclobunofen, flupymezotiaz, fentiazoluron, 1-(1,2-dimethylpropyl)-5-methyl-N-prop-2-ynyl-N-(3-pyridyl)pyrazole-4-carboxamide, 1 -[4- [5-ethylsulfonyl-1-methyl-4-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imidazol-2- yl]phenyl]cyclopropanecarbonitrile, [(Z)-[[3-ethylsulfonyl-5-[4-(trifluoromethoxy)phenyl]-2-pyridyl]-[[5- (trifluoromethyl)-2-pyridyl]amino]methylene]amino] acetate, 3-[3-ethylsulfonyl-5-[4- (trifluoromethoxy)phenyl]-2-pyridyl]-4-[5-(trifluoromethyl)-2-pyridyl]-1,2,4-oxadiazol-5-one, 1-(4- chlorophenyl)-2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfanyl)benzene, and emamectin benzoate; and to methods of controlling or preventing damage to plants using such combinations; and to formulations, concentrates and seed treatments comprising such combinations.

The present invention discloses a steroidal derivative containing a pyrazole-thiazolinone heterocycle and its preparation method and application. The steroidal derivative containing a pyrazole-thiazolinone heterocycle of the present invention has a strong inhibitory effect on nitric oxide (NO) produced by lipopolysaccharide (LPS)-induced RAW 264.7 mouse peritoneal macrophages and BV2 mouse microglial neurons, especially the anti-inflammatory activity of compound 5 prepared by the preparation method is better than dexamethasone, and the toxicity is less than dexamethasone, and the effect of different substituents on the inhibitory activity can be combined to expand the in-depth application of steroidal derivatives of pyrazole-thiazolinone heterocycles in fighting inflammation. The compound of the present invention is simple to prepare, and the raw materials are easy to obtain. More importantly, it has good anti-inflammatory activity and lower cytotoxicity, which is of great significance in the preparation of drugs for preventing and treating inflammation / neuroinflammation or autoimmune-related diseases.

The present invention discloses a steroidal dihydropyrazole thiazoline derivative, 3β-hydroxy-pregnane-5-en-17β-yl-5'-(substituted phenyl)-1'-(4''-phenyl-[1'',3'']-thiazol-2''-yl)-4',5'-dihydropyrazole-3'-yl. The present invention also discloses the use of the steroidal dihydropyrazole thiazoline derivative. The steroidal dihydropyrazole thiazoline derivative of the present invention has a strong inhibitory effect on nitric oxide (NO) production in RAW 264.7 mouse peritoneal macrophages induced by lipopolysaccharide (LPS), especially compound 4 in the prepared steroidal dihydropyrazole thiazoline derivative has an IC of 0.05. 50 The value is better than that of the positive control methylprednisolone, and the toxicity to cells is low. The steroidal derivative containing a dihydropyrazole thiazoline heterocycle provided by the present invention is a new structural compound, which shows higher activity than existing first-line anti-inflammatory drugs.

The invention discloses a hederagenin C-23 heterocyclic ester derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemistry. The structure of the derivative is shown in the specification, wherein R represents pyrazole, thiazole, oxazole, furan, pyrimidine, pyrazine or indole. Pharmacological tests show that part of hederagenin C-23 heterocyclic ester derivatives (T-BZ, T-SZ, T-EZ, T-MD and TBQ) prepared by the invention have better MDR reversal activity than verapamil, can significantly increase the sensitivity (p < 0.0001) of drug-resistant KBV cells to paclitaxel, are P-gp inhibitors with more excellent MDR reversal activity, can be used in combination with common antitumor drugs, and can be used for preparing drugs for treating tumors. The good anti-tumor activity is realized.

The present invention relates to a method for controlling undesirable vegetation in an aquatic environment in which a rice plant is growing. In the method of this invention, a herbicidally effective amount of a herbicide A or of a composition comprising the herbicide A is applied to the aquatic environment pre-emergence or early post-emergence of the undesirable vegetation and after germination of the rice seedlings wherein the herbicide A is selected from acetochlor, acifluorfen, alachlor, aminopyralid, bensulfuron, benzobicyclon, bicyclopyrone, bispyribac, butylate, carfentrazone, chlorimuron, chlorsulfuron, cinmethylin, clethodim, clodinafop, clomazone, clopyralid, cycloate, cyhalofop, 2,4-D, dicamba, diflufenzopyr, dimethenamid, dimethenamid-P, dithiopyr, EPTC, ethalfluralin, ethofumesate, fenoxaprop, fenoxaprop-P, florpyrauxifen, fluazifop, fluazifop-P, flufenacet, flumiclorac, flumioxazin, fluroxypyr, fluthiacet, fomesafen, halauxifen, halosulfuron, iodosulfuron, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, isoxaflutole, lactofen, MCPA, mesosulfuron, mesotrione, metolachlor, S-metolachlor, metsulfuron, MSMA, nicoculfuron, orthosulfamuron, penoxsulam, pinoxaden, primisulfuron, propanil, propyzamide, pyrasulfotole, pyrithiobac, pyroxasulfone, pyroxulam, quinclorac, quizalofop, quizalofop-P, rimsulfuron, saflufenacil, sethoxydim, sulfentrazone, sulfosulfuron, tembotrione, tetflupyrolimet, thifensulfuron, thiobencarb, tiafenacil, tolpyralate, topramezone, triallate, triasulfuron, tribenuron, triclopyr, trifloxysulfuron, trifludimoxazin, trifluralin, triflusulfuron and agriculturally acceptable salts or derivatives thereof. The method is particularly suitable for weed control in flooded rice fields.

The invention relates to the technical field of preparation of biodegradable materials, and particularly discloses a method for biosynthesizing three compounds olefin IMZ, CMDIA and CMI0, which comprises the following steps: culturing a white-rot fungus strain to obtain a fungus culture; adding imidaclothiz into the fungal culture, and carrying out a biotransformation reaction under a standing condition; carrying out extraction and purification treatment on the culture subjected to biotransformation, and separating to obtain target compounds olefin IMZ, CMDIA and CMIO; according to the present invention, by optimizing the degradation metabolism pathway of the white-rot fungi Phanerochaete sordida YK-624, the three target compounds olefin IMZ, CMDIA and CMIO can be synchronously generated in the single bioconversion reaction, and compared with the traditional chemical synthesis or step-by-step bioconversion process, the complex processes of multi-step reaction and separation are omitted, the production period is substantially shortened, the production cost is reduced, and the production efficiency is improved. The time cost and the operation complexity are reduced, and the overall synthesis efficiency is remarkably improved.

The application discloses a steroid pyrazole-thiazolone derivative containing thiophene and pyridine, a preparation method and application thereof. The steroid pyrazole-thiazolone derivative containing thiophene and pyridine provided by the application can significantly inhibit the production of NO (nitric oxide) of BV-2 microglial cells induced by LPS (lipopolysaccharide), wherein the anti-inflammatory activity of compound 2 is the most significant, the IC50 value of the compound 2 is 2.05 micromoles / L, which is superior to the positive control progesterone, and the compound 2 can inhibit the expression of downstream inflammatory proteins iNOS and COX-2 by inhibiting the NF-kappa B signal pathway, thereby exerting the anti-neuroinflammatory activity, and the compound 2 can be used for preparing a medicine for treating and / or preventing neurodegenerative diseases; the compound 2 is stable in structure, convenient to store, and can be developed as a lead derivative for preventing and treating neurodegenerative diseases (such as Alzheimer's disease), neuroinflammatory diseases and other related diseases.

The invention relates to an insecticidal composition containing imidaclothiz and spirotetramat, the insecticidal composition comprises an active component, and the active component comprises imidaclothiz and spirotetramat; the mass ratio of the imidaclothiz to the spirotetramat is (1 to 3): (3 to 1); the mass of the active ingredients accounts for 10%-38% of the total mass of the insecticidal composition. The insecticidal composition containing imidaclothiz and spirotetramat provided by the invention can cover different development stages of pests, so that the prevention effect persistence is improved; the two targets a lipid metabolism system and a nervous system respectively, so that the risk of cross resistance is avoided, the development of pest resistance can be delayed, and the field control effect synergy is enhanced.