4 results about "Imidaclothiz" patented technology

The present invention relates to combinations of a compound of formula (A-1) with a compound selected from the group consisting of dimpropyridaz, emamectin and isocycloseram, bentioflumin, pioxaniliprole, isoflualanam, cybenzoxasulfyl, vinylfluthrin, cyclobunofen, flupymezotiaz, fentiazoluron, 1-(1,2-dimethylpropyl)-5-methyl-N-prop-2-ynyl-N-(3-pyridyl)pyrazole-4-carboxamide, 1 -[4- [5-ethylsulfonyl-1-methyl-4-[3-methyl-6-(trifluoromethyl)imidazo[4,5-b]pyridin-2-yl]imidazol-2- yl]phenyl]cyclopropanecarbonitrile, [(Z)-[[3-ethylsulfonyl-5-[4-(trifluoromethoxy)phenyl]-2-pyridyl]-[[5- (trifluoromethyl)-2-pyridyl]amino]methylene]amino] acetate, 3-[3-ethylsulfonyl-5-[4- (trifluoromethoxy)phenyl]-2-pyridyl]-4-[5-(trifluoromethyl)-2-pyridyl]-1,2,4-oxadiazol-5-one, 1-(4- chlorophenyl)-2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfanyl)benzene, and emamectin benzoate; and to methods of controlling or preventing damage to plants using such combinations; and to formulations, concentrates and seed treatments comprising such combinations.

The invention discloses a hederagenin C-23 heterocyclic ester derivative as well as a preparation method and application thereof, and belongs to the technical field of organic chemistry. The structure of the derivative is shown in the specification, wherein R represents pyrazole, thiazole, oxazole, furan, pyrimidine, pyrazine or indole. Pharmacological tests show that part of hederagenin C-23 heterocyclic ester derivatives (T-BZ, T-SZ, T-EZ, T-MD and TBQ) prepared by the invention have better MDR reversal activity than verapamil, can significantly increase the sensitivity (p < 0.0001) of drug-resistant KBV cells to paclitaxel, are P-gp inhibitors with more excellent MDR reversal activity, can be used in combination with common antitumor drugs, and can be used for preparing drugs for treating tumors. The good anti-tumor activity is realized.

The application discloses a steroid pyrazole-thiazolone derivative containing thiophene and pyridine, a preparation method and application thereof. The steroid pyrazole-thiazolone derivative containing thiophene and pyridine provided by the application can significantly inhibit the production of NO (nitric oxide) of BV-2 microglial cells induced by LPS (lipopolysaccharide), wherein the anti-inflammatory activity of compound 2 is the most significant, the IC50 value of the compound 2 is 2.05 micromoles / L, which is superior to the positive control progesterone, and the compound 2 can inhibit the expression of downstream inflammatory proteins iNOS and COX-2 by inhibiting the NF-kappa B signal pathway, thereby exerting the anti-neuroinflammatory activity, and the compound 2 can be used for preparing a medicine for treating and / or preventing neurodegenerative diseases; the compound 2 is stable in structure, convenient to store, and can be developed as a lead derivative for preventing and treating neurodegenerative diseases (such as Alzheimer's disease), neuroinflammatory diseases and other related diseases.

The invention relates to an insecticidal composition containing imidaclothiz and spirotetramat, the insecticidal composition comprises an active component, and the active component comprises imidaclothiz and spirotetramat; the mass ratio of the imidaclothiz to the spirotetramat is (1 to 3): (3 to 1); the mass of the active ingredients accounts for 10%-38% of the total mass of the insecticidal composition. The insecticidal composition containing imidaclothiz and spirotetramat provided by the invention can cover different development stages of pests, so that the prevention effect persistence is improved; the two targets a lipid metabolism system and a nervous system respectively, so that the risk of cross resistance is avoided, the development of pest resistance can be delayed, and the field control effect synergy is enhanced.