Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of mebendazole chewable tablets

A technology of mebendazole and chewable tablets, which is applied in the field of medicine, can solve problems such as difficulties in drug treatment, achieve the effects of effectively stabilizing pain, avoiding side effects, and improving use value

Active Publication Date: 2020-08-07
REYOUNG PHARMA
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is becoming more and more difficult to treat with medication

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of mebendazole chewable tablets
  • Preparation method of mebendazole chewable tablets
  • Preparation method of mebendazole chewable tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Prescription

[0050]

[0051] 2. Process

[0052]Weigh the prescribed amount of mebendazole, mannitol, lactose, crospovidone, and aspartame, add them into a wet granulator, add an appropriate amount of purified water, tartrazine, and sunset yellow, and make a suitable soft material. Granules, pump the prepared wet granules into the fluidized bed, and dry until the moisture content is ≤4%.

[0053] After the above granules are crushed and granulated by a granulator, the prescription amount of essence and magnesium stearate is added, mixed evenly, and compressed into tablets.

Embodiment 2

[0055] 1. Prescription

[0056]

[0057] 2. Process

[0058] Weigh the prescribed amount of mebendazole, mannitol, lactose, crospovidone, and aspartame, add to a wet granulator, add an appropriate amount of povidone K30 aqueous solution, sunset yellow, and tartrazine to make a suitable soft drink. Material, granulation, pump the prepared wet granules into the fluidized bed, and dry until the moisture content is ≤4%.

[0059] After the above granules are crushed and granulated by a granulator, the prescription amount of essence and magnesium stearate is added, mixed evenly, and compressed into tablets.

Embodiment 3

[0061] 1. Prescription

[0062]

[0063]

[0064] 2. Process

[0065] Weigh the prescribed amount of mebendazole, mannitol, lactose, sucrose, crospovidone, aspartame, add to the wet granulator, add an appropriate amount of povidone K30 aqueous solution, sunset yellow, tartrazine, and make a suitable The soft material is granulated, and the prepared wet granules are pumped into the fluidized bed, and dried until the moisture content is ≤4%.

[0066] After the above granules are crushed and granulated by a granulator, the prescription amount of essence and magnesium stearate is added, mixed evenly, and compressed into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of mebendazole chewable tablets. The preparation method comprises the following steps: (1) adding mebendazole and auxiliary materials into a wet granulator according to a prescription amount, and premixing the components; (2) adding a prescription amount of adhesive, sunset yellow and lemonyellow to prepare a soft material; (3) granulating the prepared soft material by using a wet granulating machine; (4) pumping the wet granules into a fluidized bed for drying by using vacuum, and straightening the granules by using a crushing and straightening machine; and (5) adding essence and a lubricant into the granulated granules, mixing all the components, and tabletting the mixture to obtain the mebendazole chewable tablet. The preparation method disclosed by the invention is simple in process and good in batch-to-batch reproducibility, the production process meets the requirements ofGMP, and the preparation method is suitable for industrial large-scale production; the chewable tablet prepared by the method is stable in quality and good in taste.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method of mebendazole chewable tablets. Background technique [0002] Mebendazole is a broad-spectrum anthelmintic drug. Both in vivo and in vitro tests have proved that it can directly inhibit the intake of glucose by nematodes, leading to the depletion of glycogen and making it unable to survive. It has a significant effect of killing larvae and inhibiting the development of eggs. , but does not affect blood sugar levels in the human body. It can be used to prevent and control intestinal parasitic diseases such as hookworms, roundworms, pinworms, whipworms, and fecal nematodes. [0003] Mebendazole can interfere with the microtubule formation of parasite intestinal cells by specifically binding to tubulin, which can degrade the intestinal ultrastructure of parasites, thereby destroying the absorption and digestion of glucose by parasites, and finall...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4184A61P33/02
CPCA61K31/4184A61K9/0056A61K9/2077A61K9/2054A61P33/02Y02A50/30
Inventor 苗得足黄京山李伟陈传永
Owner REYOUNG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com