54results about How to "Meet the requirements of GMP" patented technology

The solid medicine filling machine comprises power drive component, central dial, take-in and take-out component, bag-cutting part, part for filling clean air, part for filling nitrogen, thermal sealing part, rack and electric control cabinet. The parts above are set on the side of the center dial that connects with the power drive component and are supported by the rack to layout in turn. Around the central dial is fitted with a bag holder for hanging infusion bag.

The invention discloses a preparation method of licorice particles for livestock and poultry, comprising the following steps of: firstly taking licorice, placing it into an extraction pot to form a medicinal material layer, adding water and immersing, adjusting the operating temperature of the extraction pot to 60-80 DEG C for extraction, leading out parts of an extract from the bottom of the extraction pot during the extraction process and carrying out vacuum concentration while the concentration temperature is 50-70 DEG C, condensing steam generated by the concentration, returning the stream used as a new solvent into the extraction pot for permeating extraction of the medicinal material layer, continuously repeating for 2-3 hours, condensing to finally obtain a fluid extract, adding anhydrous glucose and maltodextrin or cyclodextrin and the fluid extract into a spray drying granulator, and carrying out granulation so as to obtain the licorice particles for livestock and poultry. According to the preparation method of the licorice particles for livestock and poultry, the two processes of licorice extraction and condensation are synchronously carried out so as to change a high-temperature decocting technology of a traditional extraction pot under pressure and at normal pressure. Therefore, energy can be saved by 0.3-0.5 time; the amount of a hydrosolvent is minimized by 0.5-1 time; the feeding amount is increased by 30-60%; extract yielding rate is raised by more than 10%; the storage process is minimized; and electric power energy is saved by more than 30%.

The invention relates to a method for absorbing and separating a human prothrombin complex by utilizing an expansion bed, comprising the following steps: (a) separating cryoprecitation from melted refrigerated plasma by using a refrigeration type continuous flow centrifuge, and collecting supernate as a raw material; (b) carrying out stable expansion on an expansion bed by using a buffer solution A, wherein the buffer solution A is 0.05mol/L1tris-citric acid with the PH value of 7.0; (c) rapidly switching into a feed solution after the expansion bed is in stable balance, stopping feeding and rapidly switching into the buffer solution A when breakthrough points reaches 5-10%, and washing in an expanded mode; and (d) switching into buffer solutions of 0.4mol/L NaCl and 1.6mol/L NaCl after washing, carrying out gradient elution in a stationary bed mode, and collecting the protein elution peak of the buffer solution of 1.6mol/L NaCl to obtain a prothrombin complex crude product.

The invention relates to a potassium chloride sustained-release pellet and a preparation method and application thereof. The potassium chloride sustained-release pellet provided by the invention comprises a pellet core, a potassium chloride main drug layer, an isolated layer, a sustained-release coating layer and a colored coating layer. According to the potassium chloride sustained-release pelletprepared in the invention, the release amount within 1 hour is smaller than or equal to 25%, the release amount within 4 hours is smaller than or equal to 70%, and the release amount of the potassiumchloride sustained-release pellet within 8 hours is smaller than or equal to 85%. By using the sustained-release coating material, the drug is released stably by accurately controlling the sustained-release speed of potassium chloride inside the potassium chloride sustained-release pellet, an expected blood concentration is obtained, relatively long action time can be maintained, the phenomenon of sudden release does not exist, and adverse reactions such as stimulation for gastric mucosa can be avoided.

The invention discloses an upright bottle cleaning machine, which comprises a work station box including a worm gear transmission assembly, a lifting swinging combined cam transmission assembly, a swinging hollow shaft and a central rotation shaft. The worm gear of the worm gear transmission assembly is connected to the central rotation shaft, the lifting swinging combined cam transmission assembly is connected to the swinging hollow shaft, the central rotation shaft is fixedly connected to an extension central shaft via a coupling, the extension central shaft is connected with a central rotary disc, the central rotary disc is provided with at least one group of pincers, the swinging hollow shaft is connected with a swinging cross which is connected with a swinging needle holder through a swinging ring, the swinging hollow shaft is fitted outside the central rotation shaft, lifting and swinging of the swinging needle holder are realized by one set of the lifting swinging combined cam transmission assembly in the work station box, rotation of the pincers rotary disc is realized by one set of the worm gear transmission assembly in the work station box, and the work station box is soaked below lubricating oil and sealed both at the end face and in the axial direction to ensure that main transmission causes no contamination to cleaning water and gas of the bottle cleaning machine.

The invention discloses a preparation method of indigowoad root and indigowoad leaf particles used for livestock and poultry. First, indigowoad root and indigowoad leaf are placed in an extraction tank, such that a medicine material layer is formed; the materials are soaked by using water; the working temperature of the extraction tank is regulated to 60-80 DEG C, and extraction is carried out; during the extraction process, a part of the extraction solution is fetched from the bottom of the extraction tank, and is subjected to vacuum concentration, wherein the concentration temperature is 50-70 DEG C; vapor generated by concentration is condensed and adopted as a novel solvent, and is delivered back to the extraction tank for carrying out percolation extraction upon the medicine material layer; the steps are repeated for 2-3h, and a fluid extract is obtained by concentration; anhydrous dextrose, maltodextrin or cyclodextrin, and the fluid extract are added into a spray-drying granulator for granulation, such that the indigowoad root and indigowoad leaf particles used for livestock and poultry are obtained. According to the preparation method of the indigowoad root and indigowoad leaf particles used for livestock and poultry, two processes which are the extraction and concentration of the indigowoad root and indigowoad leaf are carried out simultaneously, a pressurized and normal-pressure boiling process in a traditional extraction tank is changed, such that energy can be saved by 0.3-0.5 times, the dosage of a water solvent can be reduced by 0.5-1 time, a feeding amount is increased by 30-60%, an extract yield is increased by more than 10%, a storage process is reduced, and electric energy is saved by more than 30%.

The invention relates to a bottle washer spray needle frame with spray needles having adjustable hydraulic pressure balance. The bottle washer spray needle frame comprises the spray needles, a needle frame, sealing gaskets and throttling orifices with different bore diameters. The throttling orifices are mounted between connecting surfaces of the spray needles and the needle frame, the sealing gaskets are mounted on the throttling orifices, an outer convex surface of each spray needle is a V-shaped outer conical surface, two symmetric support lugs are arranged at ends of each spray needle, an inner concave surface of the needle frame is a V-shaped inner conical surface, a groove provided with two symmetric notches is arranged at an end of the needle frame, and the convex surface support lugs on the spray needles are aligned to the notches at the upper end of the concave surface of the needle frame and are embedded into the groove on the needle frame. By means of connection of a fastened rapid connector, the spray needles and a support are connected together, the throttling orifices and the sealing gaskets capable of adjusting water pressure are added between the spray needles and the support, spray pressures of the spray needles of a bottle washer are ensured to be approximately equal by adjusting diameters of the throttling orifices, and each bottle can be sufficiently cleaned.

The invention belongs to the technical field of medicine and particularly relates to trimetazidine hydrochloride tablets and a preparation method thereof. The trimetazidine hydrochloride tablets are prepared from raw materials as follows: trimetazidine hydrochloride, filler, a binder, a lubricant and a wetting agent. The trimetazidine hydrochloride tablets solve the problems of poor compressibility and difficulty in forming of the trimetazidine hydrochloride as the raw material. The invention further provides the preparation method of the trimetazidine hydrochloride tablets. The compressibility of the prepared trimetazidine hydrochloride tablets is improved, the trimetazidine hydrochloride tablets are formed easily, the use value of the trimetazidine hydrochloride tablets can be increased better, trimetazidine hydrochloride is prepared into tablets to facilitate taking of a patient, pain of the patient can be relieved timely, the process is simple, the quality is stable, a production process meets the requirement of GMP (Good Manufacture Practice of Drugs), and the trimetazidine hydrochloride tablets and the preparation method are applicable to industrial mass production.

The invention discloses a filling tracking manipulator comprising an upper servo motor (3), a lower servo motor (4), a lower swing arm transmission shaft (5), a lower swing arm (6), a link holder (7), an upper swing arm assist rod (8), a middle link (9), a filling needle rack (10), an upper swing arm transmission shaft (11), a middle shaft (12), an upper swing arm (13), an assist support (14), and a lower swing arm assist rod (15). The link holder (7), the upper swing arm assist rod (8), the middle link (9) and the upper swing arm (13) form an upper parallelogram link mechanism. The lower swing arm (6), the link holder (7), the lower swing arm assist rod (15) and the assist support (14) form a lower parallelogram link mechanism. The servo motors drive the upper swing arm transmission shaft and the lower swing arm transmission shaft to rotate at certain angles respectively, so that the filling needle rack is horizontal constantly; tracking is fast and stable and production efficiency is high.

The invention discloses a filling action mechanism of a filling machine. The filling action mechanism is characterized by comprising a mechanical arm main shaft, wherein one end of the mechanical arm main shaft penetrates through a hollow speed reducer and is connected with one end of a large mechanical hand arm; the other end of the large mechanical hand arm is connected with one end of a small mechanical hand arm through a mechanical hand countershaft; the output end of the hollow speed reducer is connected with the small mechanical hand arm through a connecting joint, a first movable joint and a second connecting rod; the other end of the small mechanical hand arm is provided with a needle rack fixing shaft; the needle rack fixing shaft is provided with a needle rack; and the needle rack is always horizontal to the ground surface through the effect of movable devices and is provided with a filling needle. The filling action mechanism has the characteristics of being high in integration level, being capable of realizing modularized installation and disassembling, being more convenient to maintain, and the like.

The invention discloses a bottle clamp mechanism which is characterized by comprising a cylinder. The cylinder is arranged on a cylinder fixing base, a cylinder piston rod on the cylinder is connected with one end of a push rod, a bottle clamp driving shaft is arranged on one side of the other end of the push rod, the bottle clamp driving shaft penetrates through a tail through hole of a bottle clamp installation left fixed block and a tail through hole of a bottle clamp installation right fixed block, the bottle clamp installation left fixed block and the bottle clamp installation right fixed block are connected through a bottle clamp installation plate, the bottle clamp installation plate is connected with a primary bottle clamp and a secondary bottle clamp through bottle clamp rotating pins, teeth of the primary bottle clamp and teeth of the secondary bottle clamp are meshed with each other, and the tail of the primary bottle clamp is contacted with the bottle clamp driving shaft. The bottle clamp mechanism has the advantages of being simple in structure, stable to operate, adjustable in bottle clamp opening, capable of performing overload protection, wide in application range and the like.

The invention discloses a human anti-thrombin III heparin combination ratio detection method. The detection method comprises the steps of using an efficient size exclusion chromatography column and a sodium salt buffer solution with mobile phases comprising isopropanol and phosphoric acid at pH of 6.0-7.5 to calculate a combination ratio between the human anti-thrombin III and the heparin through a ratio of an area of characteristic peak and a corresponding standard curve; adding inactivated human anti-thrombin III into a standard product of the human anti-thrombin III according to a ratio, and manufacturing a standard curve according to change of the ratio of the area of characteristic peak. According to the method, the human factors are excluded; the accuracy and the precision of results are high, the experiment operation steps are simple, the detection time can be shortened, the experiment cost is reduced and the working efficiency of detectors is greatly improved.

The invention relates to a process for preparing Ziprasidone or its salt inclusion compound, which comprises the steps of, (1) providing a solution of Ziprasidone or its salts, heating the solution at 78+-1.5 deg C to dissolve Ziprasidone or its salts, (2) filtering non-soluble substance in the solution, then drying the dissolvent.

The invention relates to a spray-needle buckled type quick connector for a bottle washing machine, which comprises a spray needle, a spray needle frame and a sealing pad. The spray needle comprises a convex head spray needle seat and a needle tube which are welded together. The spray needle frame comprises a concave head spray needle seat and a support. The sealing pad with effect of sealing and shock absorption is arranged at the connection position between the spray needle and the spray needle frame. The buckled quick connector uses unique design of connection between the spray needle and the spray needle frame, changes an original threaded sealing connection method between the spray needle and the spray needle frame into quick buckled sealing connection, avoids secondary pollution, guarantees cleaning quality of bottles and meets requirements of new-edition good manufacturing practice (GMP).

The invention discloses a preparation method of common andrographis herb bitter granules. The method comprises the steps of placing common andrographis herb, radix astragali seu hedysari, fructus evodiae, radix et rhizoma rhei, radix angelicae dahuricae, radix sophorae flavescentis, herba taraxaci, radix pulsatillae chinensis and liquorice root into an extraction tank to form a medicine layer, adding water for soaking, and then adjusting the operating temperature of the extraction tank to be 70-80 DEG C; leading out extract from the bottom of the extraction tank in an extracting process and concentrating under the reduced pressure, wherein the concentration temperature is 60-70 DEG C; condensing steam, produced by concentration, as a new solvent, and returning to the extraction tank for carrying out percolation extracting on the medicine layer; repeating the operations for 2-4h, and finally concentrating to obtain fluid extract; taking saccharose and cyclodextrin and then adding into aspray drying granulating machine together with the fluid extract for granulating so as to obtain the common andrographis herb bitter granules. According to the preparation method, the two processes,i.e., extraction and concentration of raw medicine materials are performed synchronously, and changes the process of high-temperature boiling, concentration and fractionation in the traditional extraction tank with pressure and under the atmospheric pressure, thus saving the energy by 0.2-0.4 time, reducing the consumption of a water solvent by 0.3-1 time, and saving labor time by 1-2h; furthermore, after the preparation method is adopted, the extract yield is increased by about 12%, and the product cost is lowered.