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Pharmaceutical pellet cores and preparation method thereof

A ball core and micro-pill technology, which is applied in the field of medicinal micro-pill core and preparation, can solve the problems of being unsuitable for large-scale production in factories, many factors in large-scale production, and poor product process reproducibility, etc., to achieve round shape and production The effect of high efficiency and quality assurance of finished products

Active Publication Date: 2013-05-22
珠海润都制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The problem existing in the existing preparation method is that the powder needs to be sprinkled into the preparation process, which results in high dust pollution, more equipment needs to be used in the operation process, the operation is complicated, and it needs to rely on human experience to operate. There are many unfavorable factors for large-scale production, product technology Poor reproducibility, poor stability, high cost, not suitable for large-scale production in factories

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Example 1: Medicinal pellet core

[0029] Prescription: caster sugar 100Kg, medicinal starch 50Kg, hypromellose E61.5Kg, the balance is purified water

[0030] The preparation method of medicinal pellet core of the present invention is as follows:

[0031] 1), sub-sieve young granulated sugar: the young granulated sugar is passed through a 40-mesh sieve and a 60-mesh sieve, and the young granulated sugar smaller than 60 mesh and greater than 40 mesh is put in a pulverizer to pulverize through a 100-mesh sieve. Take 40-60 mesh caster sugar for later use.

[0032] 2) Preparation of suspension: Dissolve 1.5Kg of HPMC E6 in purified water and stir until completely dissolved; add 50Kg of medicinal starch and 50Kg of granulated sugar powder under high-speed stirring, and stir until there is no agglomeration in the suspension. Strain through a sieve and stir at medium speed for later use.

[0033] 3), pellet core making: put the 40-60 mesh 50Kg young granulated sugar sieved...

example 2

[0035] Example 2: Medicinal pellet core

[0036] Prescription: caster sugar 80Kg, medicinal starch 70Kg, hypromellose E52.25Kg, the balance is purified water

[0037] The preparation method of medicinal pellet core of the present invention is as follows:

[0038] 1), sub-sieve young granulated sugar: the young granulated sugar is passed through a 40-mesh sieve and a 60-mesh sieve, and the young granulated sugar smaller than 60 mesh and greater than 40 mesh is put in a pulverizer to pulverize through a 100-mesh sieve. Take 40-60 mesh caster sugar for later use.

[0039] 2) Preparation of suspension: Dissolve 2.25Kg of HPMC E5 in purified water and stir until completely dissolved; add 70Kg of medicinal starch and 30Kg of granulated sugar powder under high-speed stirring, and stir until there is no agglomeration in the suspension. Strain through a sieve and stir at medium speed for later use.

[0040] 3), pellet core making: put the 40-60 mesh 50Kg young granulated sugar sieve...

example 3

[0042] Example 3: Medicinal pellet core

[0043] Prescription: caster sugar 105Kg, medicinal starch 45Kg, hypromellose E33.0Kg, the balance is purified water

[0044] The preparation method of medicinal pellet core of the present invention is as follows:

[0045]1), sub-sieve young granulated sugar: the young granulated sugar is passed through a 40-mesh sieve and a 60-mesh sieve, and the young granulated sugar smaller than 60 mesh and greater than 40 mesh is put in a pulverizer to pulverize through a 100-mesh sieve. Take 40-60 mesh caster sugar for later use.

[0046] 2) Preparation of suspension: Dissolve 3.0Kg of HPMC E3 in purified water and stir until completely dissolved; add 45Kg of medicinal starch and 55Kg of granulated sugar powder under high-speed stirring, and stir until there is no agglomeration in the suspension. Strain through a sieve and stir at medium speed for later use.

[0047] 3), pellet core making: put the 40-60 mesh 50Kg young granulated sugar sieved ...

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Abstract

The invention belongs to the pharmaceutical field, and relates to a drug carrier and a preparation method of the drug carrier, specificly to pharmaceutical pellet cores and a preparation method of the pellet cores. The preparation method provided by the invention comprises the following steps: 1) sieving fine granulated sugar; 2) preparing a suspension by dissolving hydroxypropyl methylcellulose in water and stirring to dissolve; adding starch and the milled fine granulated sugar powder, stirring evenly and sieving; 3) preparing pellet cores in one step by placing sieved fine granulated sugarfrom step 1) in a fluidized bed, starting side spray process of the fluidized bed and adjusting the rotary speed, starting spray and adjusting the spray speed, drying after spray of the mixed suspension of sugar and starch is completed and discharging; and 4) sieving and packaging the dried pellet cores.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a drug carrier and a preparation method thereof, in particular to a medicinal pellet core and a preparation method thereof. Background technique [0002] Blank pellets are commonly used drug carriers in the preparation industry. Many commercially available capsule preparations are loaded with drugs on blank pellets, and then coated to make target pellets with certain release requirements. It has the characteristics of good fluidity, easy to fill capsules, small difference in filling capacity, and stable drug release. Pellets are widely used in the field of pharmacy. As a drug carrier, it can be further compressed into tablets or filled with capsules, which not only improves drug stability, but also effectively regulates drug release rate. System, micropills also have therapeutic advantages, it is less irritating to the intestinal tract, reduces the burst release effect of the drug, and impr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/36A61K47/26A61K9/16A61K9/48A61J3/06
Inventor 张志刚莫泽艺杨冬
Owner 珠海润都制药股份有限公司
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