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Trimetazidine hydrochloride tablets and preparation method thereof

A technology selected from trimetazidine hydrochloride, which is applied in the field of trimetazidine hydrochloride tablets and its preparation, can solve the problems of difficult molding and poor compressibility, and achieve increased fluidity, reduced myocardial oxygen consumption and Cardiac energy, the effect of reducing the workload of the heart

Inactive Publication Date: 2015-11-18
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the disadvantages of poor compressibility of existing trimetazidine hydrochloride and difficult molding, the purpose of the present invention is to provide a trimetazidine hydrochloride tablet, which has enhanced compressibility, is easy to form, and can better improve the quality of koji hydrochloride. The use value of metazine tablet, the present invention also provides its preparation method, and process is simple, and quality is stable

Method used

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  • Trimetazidine hydrochloride tablets and preparation method thereof
  • Trimetazidine hydrochloride tablets and preparation method thereof
  • Trimetazidine hydrochloride tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Prescription

[0026]

[0027] 2. Process

[0028] Trimetazidine hydrochloride was passed through a 22-mesh mesh sieve. Weigh 2.2kg trimetazidine hydrochloride, 2.8kg microcrystalline cellulose, 3.4kg pregelatinized starch and 0.4kg polyethylene glycol 6000 according to the prescription and mix them evenly. Add 1.3 kg of tragacanth gum ethanol solution with a concentration of 20%, granulate with an 18-mesh sieve, dry and granulate. Add 0.3kg lauryl magnesium sulfate and 0.1kg magnesium stearate and mix and then compress into tablets to obtain the trimetazidine hydrochloride tablet of the present invention.

Embodiment 2

[0030] 1. Prescription

[0031]

[0032] 2. Process

[0033] Trimetazidine hydrochloride was passed through a 22-mesh mesh sieve. Take by weighing 2.4kg of trimetazidine hydrochloride, 2.7kg of mannitol, 3.3kg of lactose and 0.5kg of methylcellulose and mix them evenly. Add 1.4kg concentration of 20% ethanol solution of gum arabic, granulate with 18 mesh sieve, dry and granulate. Add 0.15kg of silicon dioxide and 0.15kg of talcum powder for total mixing and then compress into tablets to obtain the trimetazidine hydrochloride tablet of the present invention.

Embodiment 3

[0035] 1. Prescription

[0036]

[0037] 2. Process

[0038] Trimetazidine hydrochloride was passed through a 22-mesh mesh sieve. Take by weighing 2.3kg trimetazidine hydrochloride, 2.9kg dextrin, 3.2kg lactose and 0.4kg hypromellose and mix uniformly according to the prescription. Add 1.2 kg of 20% ethanol solution of gum arabic, granulate with 18 mesh sieve, dry and granulate. Add 0.1kg lauryl magnesium sulfate and 0.2kg talcum powder and mix and compress into tablets to obtain the trimetazidine hydrochloride tablet of the present invention.

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PUM

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Abstract

The invention belongs to the technical field of medicine and particularly relates to trimetazidine hydrochloride tablets and a preparation method thereof. The trimetazidine hydrochloride tablets are prepared from raw materials as follows: trimetazidine hydrochloride, filler, a binder, a lubricant and a wetting agent. The trimetazidine hydrochloride tablets solve the problems of poor compressibility and difficulty in forming of the trimetazidine hydrochloride as the raw material. The invention further provides the preparation method of the trimetazidine hydrochloride tablets. The compressibility of the prepared trimetazidine hydrochloride tablets is improved, the trimetazidine hydrochloride tablets are formed easily, the use value of the trimetazidine hydrochloride tablets can be increased better, trimetazidine hydrochloride is prepared into tablets to facilitate taking of a patient, pain of the patient can be relieved timely, the process is simple, the quality is stable, a production process meets the requirement of GMP (Good Manufacture Practice of Drugs), and the trimetazidine hydrochloride tablets and the preparation method are applicable to industrial mass production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a trimetazidine hydrochloride tablet and a preparation method thereof. Background technique [0002] Trimetazidine Hydrochloride Tablets are clinically applicable to coronary insufficiency, angina pectoris, angina pectoris ineffective for hemodynamic drugs alone, diabetic coronary heart disease, old myocardial infarction, etc. Trimetazidine Hydrochloride Tablets belong to other antianginal cardiovascular drugs. Trimetazidine protects the energy metabolism of cells under hypoxic or ischemic conditions and prevents the decline of intracellular ATP levels, thereby ensuring the normal function of ion pumps. And the normal operation of transmembrane sodium-potassium flow, maintaining the stability of the intracellular environment. Animal studies have found: Trimetazidine: Helps maintain energy metabolism in the heart and neurosensory organs under conditions of ischemia a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/38A61K47/40A61K47/26A61K47/10A61K31/495A61P9/10A61P1/08A61P27/16
Inventor 苗得足黄京山李伟刘乐凯
Owner REYOUNG PHARMA
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