Preparation method of common andrographis herb bitter granules

Abstract

The invention discloses a preparation method of common andrographis herb bitter granules. The method comprises the steps of placing common andrographis herb, radix astragali seu hedysari, fructus evodiae, radix et rhizoma rhei, radix angelicae dahuricae, radix sophorae flavescentis, herba taraxaci, radix pulsatillae chinensis and liquorice root into an extraction tank to form a medicine layer, adding water for soaking, and then adjusting the operating temperature of the extraction tank to be 70-80 DEG C; leading out extract from the bottom of the extraction tank in an extracting process and concentrating under the reduced pressure, wherein the concentration temperature is 60-70 DEG C; condensing steam, produced by concentration, as a new solvent, and returning to the extraction tank for carrying out percolation extracting on the medicine layer; repeating the operations for 2-4h, and finally concentrating to obtain fluid extract; taking saccharose and cyclodextrin and then adding into aspray drying granulating machine together with the fluid extract for granulating so as to obtain the common andrographis herb bitter granules. According to the preparation method, the two processes,i.e., extraction and concentration of raw medicine materials are performed synchronously, and changes the process of high-temperature boiling, concentration and fractionation in the traditional extraction tank with pressure and under the atmospheric pressure, thus saving the energy by 0.2-0.4 time, reducing the consumption of a water solvent by 0.3-1 time, and saving labor time by 1-2h; furthermore, after the preparation method is adopted, the extract yield is increased by about 12%, and the product cost is lowered.

Description

technical field [0001] The invention relates to a preparation method of Chuanku Granules, belonging to the technical field of veterinary pharmaceutical preparations. Background technique [0002] Traditional Chinese medicine granules (granules) are a new dosage form developed on the basis of decoctions and syrups. It not only maintains the characteristics of rapid absorption and rapid action of decoctions, but also overcomes the inconvenience of decoction and large dosage. It is very suitable for clinical drug administration in modern and intensive farms. It has the advantages of good palatability, small dosage, rapid drug effect, controllable quality, good stability, and convenient storage, transportation and carrying. [0003] At present, the commonly used preparation methods of Chuanku granules include traditional water extraction method and wet granulation, which have many disadvantages, such as low extraction rate of active ingredients, serious loss of active ingredient...

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used preparation methods of Chuanku granules include traditional water extraction method and wet granulation method, which have many disadvantages, such as low extraction rate of active ingredients, serious loss of active ingredients, waste of extraction energy, long production cycle, time-consuming and labor-intensive production. The granulation operation in the process is not easy to control, serious pollution, etc.