Mebendazole soft capsule

A technology of mebendazole and soft capsules is applied in the field of antiparasitic drugs, which can solve the problems of changing the behavior of drugs in the body, widespread dissemination of hydatid cysts, and uncomfortable surgery in cases, so as to improve the curative effect, improve the bioavailability, reduce the Effects of dosage and course of treatment

Active Publication Date: 2012-12-12
STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Before the 1970s, the main treatment for echinococcosis was surgical resection, but there were problems such as recurrence after surgery, leakage of a large number of protoscolees during surgery, causing widespread dissemination

Method used

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  • Mebendazole soft capsule
  • Mebendazole soft capsule
  • Mebendazole soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Mebendazole soft capsule content 1-preparation of oleic acid suspension

[0035] Weigh 0.5g of mebendazole, add 0.5ml of Span80, 10ml of peanut oil, 10ml of soybean oil, add oleic acid to 100ml, stir in a ball mill for one hour to prepare mebendazole oleic acid suspension, the concentration of mebendazole is 5mg / ml.

Embodiment 2

[0036] Example 2 Contents of Mebendazole Soft Capsule 2-Preparation of Soybean Oil Suspension

[0037] Weigh 0.5g of mebendazole, add 0.25ml of Span80, 10ml of olive oil, 10ml of oleic acid, add soybean oil to 100ml, stir in a ball mill for one hour to prepare a mebendazole oil suspension, the concentration of mebendazole It is 5mg / ml.

Embodiment 3

[0038] Example 3 Contents of mebendazole soft capsule 3-preparation of glycerol trioleate suspension

[0039] Weigh 0.5g of mebendazole, add 0.5ml of Span80, 10ml of oleic acid, 10ml of soybean oil, add glycerol trioleate to 100ml, stir in a ball mill for one hour to prepare a mebendazole oil suspension, mebendazole The concentration of azole is 5 mg / ml.

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Abstract

The invention provides a novel preparation (soft capsule) for an antiparasitic drug-mebendazole. The content of the soft capsule comprises mebendazole, a suspending agent and liquid fat; and a capsule shell is mainly composed of gelatin, water, a plasticizer, a shielding agent and an antiseptic agent. The mebendazole soft capsule can increase plasma concentration and improve curative effect when being used for treating echinococcosis and other parasitic diseases. The soft capsule is simple in preparation method, has good stability and is easy to popularize.

Description

Invention field [0001] The invention relates to an antiparasitic drug, specifically to the reform of the dosage form of mebendazole, and more specifically to a soft capsule of mebendazole oil suspension. Background technique [0002] Hydatid disease is a global human and zoonotic disease that causes serious damage to the health of humans and livestock. Hydatid disease is a disease caused by the larvae of Echinococcus parasitic in the body of an intermediate host. The main echinococcosis in my country are cystic echinococcosis (echinococcus granulosus) and alveolar echinococcosis (echinococcus granulosus). They are composed of larvae of Echinococcus granulosus (echinococcus granulosus). ) And larvae of Echinococcus multilocularis (Echinococcus multilocularis) parasitize human and animal tissues and organs. The development of echinococcosis in the body is slow, mainly due to chronic consumption, which often makes the patient lose the ability to work, especially the alveolar echino...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/4184A61K47/44A61P33/14
Inventor 张皓冰刘丛珊姜斌伍卫平王虎韩秀敏薛剑陶奕徐莉莉肖树华张超武姚俊敏王立英温爱丹王永顺刘培运徐月红
Owner STATION OF VIRUS PREVENTION & CONTROL CHINA DISEASES PREVENTION & CONTROL CENT
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