Composition of photodynamic combination drug as well as preparation method and application thereof

A photodynamic and composition technology, which is applied in the field of preparing medicines for treating hydatid disease, can solve the problems of poor clinical drug effect and large toxic and side effects of drugs, and achieve the effects of improving curative effect, reducing dosage and reducing toxic and side effects of drugs

Active Publication Date: 2020-10-09
XINJIANG MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a composition of photodynamic combined medicine and its preparation method and application, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problems of poor clinical efficacy and toxic and side effects of medicines for treating echinococcosis. big problem

Method used

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  • Composition of photodynamic combination drug as well as preparation method and application thereof
  • Composition of photodynamic combination drug as well as preparation method and application thereof
  • Composition of photodynamic combination drug as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1: The composition of this photodynamic combination medicine, comprises photosensitizer or / and chemical drug, and photosensitizer is chlorin e6, verteporfin, indocyanine green, porfimer sodium, 5-amino ketone One or more of valeric acid, temoporfin and taraporfin, the chemical drugs are albendazole, albendazole sulfoxide, mebendazole, flubendazole, oxfendazole, green One or more of Artesunate, Camelia, Tetrandrine, and Sophora japonica.

[0027] In the present invention, when the combination of photodynamic therapy and drugs is used, photodynamic therapy and anti-echinococcosis chemical drugs can be used to achieve the effect of efficiently killing hydatid worms.

[0028] Photodynamic therapy (PDT) is a new method of treating diseases with photosensitizers and lasers. By irradiating the target with a specific wavelength, the photosensitive drug accumulated in the target tissue is activated, triggering a photochemical reaction to destroy the target. The phot...

Embodiment 2

[0031] Embodiment 2: As an optimization of the above embodiments, the photosensitizer is one or more of chlorin e6 and verteporfin.

Embodiment 3

[0032] Embodiment 3: As an optimization of the above embodiment, the chemical drug is one or more of albendazole and albendazole sulfoxide.

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PUM

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Abstract

The invention relates to the technical field of preparation of medicines for treating echinococcosis, and relates to a composition of a photodynamic combination drug and a preparation method and an application thereof. The composition comprises a photosensitizer or/and a chemical drug; wherein the photosensitizer is one or more of chlorin e6, viltipofen, indocyanine green, porphin sodium, 5-aminolevulinic acid, temopofen and talapofen, and the chemical drug is one or more of albendazole, albendazole sulfoxide, mebendazole, flubendazole, oxfendazole, artesunate, peganum harmala, tetrandrine andsophora japonica. According to the invention, through photodynamic therapy, the permeability of the hydatid and the hydatid cyst wall is increased; according to the invention, the target accumulationof chemotherapeutic drugs in the echinococcosis and the cyst wall is realized, the synergistic treatment effect is achieved, the resistance of the echinococcosis and the cyst to external drugs is reduced, the curative effect of the anti-echinococcosis drugs is improved, the administration dosage and the toxic and side effects of the drugs can be greatly reduced, and the application prospect in the preparation of echinococcosis treatment drugs is excellent.

Description

technical field [0001] The invention relates to the technical field of preparing medicines for treating echinococcosis, and relates to a composition of photodynamic combined medicine, a preparation method and application thereof. Background technique [0002] Hydatid disease, also known as Echinococcosis, is a zoonotic parasitic infectious disease caused by the larvae of Echinococcus tapeworms parasitizing the human body. It is an important public safety problem worldwide. The disease is common in northern my country, North America, Europe, Russia and other places. Among them, my country is mainly prevalent in the five northwestern provinces, Inner Mongolia, Tibet, and Sichuan, and Xinjiang is a high-incidence area. Echinococcosis seriously endangers human health and hinders the development of animal husbandry. Therefore, how to inhibit echinococcosis to protect people's health and promote the economic development of animal husbandry has become an important concern in today...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K41/00A61K31/4184A61K47/69A61K9/51A61K47/26A61K47/10A61K47/34A61K47/24A61K47/28A61K47/36A61K47/42A61K47/38A61K47/32A61P33/10
CPCA61K45/06A61K41/0071A61K31/4184A61K47/6951A61K47/6929A61K9/5123A61K9/5146A61K9/5153A61K9/5161A61K9/5169A61K9/5138A61P33/10A61K2300/00Y02A50/30
Inventor 姜虎林巩月红周天娇温浩王建华赵军黄张建李飞
Owner XINJIANG MEDICAL UNIV
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