The invention belongs to the field of drip infusion, and relates to automatic saline bottle replacement equipment for the infusion department, which comprises a shell, and is characterized in that a main control motor is fixedly arranged on the upper side wall of the shell, and a main control motor shaft is arranged at the output end of the main control motor; a main control wheel is fixedly arranged on a main control motor shaft, a wheel shifting rod is fixedly arranged on the main control wheel, a grooved wheel shaft is rotatably arranged on the upper side wall of the shell, a grooved wheelshaft transmission wheel is fixedly arranged on the upper side of the grooved wheel shaft, and a grooved wheel is fixedly arranged on the lower side of the grooved wheel shaft. When a patient needs tobe transfused, a plurality of saline bottles needing to be transfused are put into the equipment, after a nurse assists in injection and transfusion and the first bottle of saline water is hung up, the nurse does not need to call for replacement, the equipment can automatically switch the next bottle of saline water, and the transfused empty bottles are recycled and collected; the infusion process can be completed at night or by a single person, personnel do not need to monitor the saline input amount and change bottles, blood absorption and backflow are avoided, waste saline bottles can be automatically collected, the recycling process is reduced, and the workload of medical staff is reduced.