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Degradable microstructure body and preparation method thereof

A technology of microstructures and microneedles, which is applied in the fields of biomedicine and medical cosmetology, can solve the problems of rapid degradation of microstructures, poor user experience, and inability to achieve long-term sustained release, and achieve easy preparation and excellent experience Effect

Inactive Publication Date: 2016-03-23
李媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These disclosed technologies have the following technical problems: when the microstructures are inserted into the skin, they produce analgesia, causing a bad experience for the user. At the same time, the microstructures degrade quickly and cannot achieve the effect of long-term sustained release.

Method used

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  • Degradable microstructure body and preparation method thereof
  • Degradable microstructure body and preparation method thereof
  • Degradable microstructure body and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Properties of Microstructures

[0024] In this experiment, the main components of the base of the microstructure are chitosan and dextrin, the diameter of the microneedle, the length of the microneedle and the center distance of the microneedle are 150 μm, 0.5 mm and 0.1 mm, respectively, the pH of the microstructure is 7.1, and the Other parameters of the structure are shown in Table 1.

[0025] Table 1.

[0026]

Embodiment 2

[0027] Example 2: Sensitivity of Microstructures

[0028] In this experiment, the main components of the base of the microstructures are ethyl hydroxyethyl cellulose, polylactic acid and hydroxymethyl cellulose, without drug or cosmetic ingredients. The diameter, length and center distance of microneedles are respectively are 120 μm, 0.5 mm and 0.1 mm, the pH of the microstructure is 7.3, and other performance parameters of the microstructure are shown in Table 2. Note: The microstructures feel the intensity when they are inserted into the skin and the duration after insertion. The feeling is divided into: poor, poor, general, better, good, and good.

[0029] Table 2

[0030]

[0031]

Embodiment 3

[0032] Example 3: Degradation performance of microstructures

[0033] In this experiment, the degradation performance of several microstructures was compared. The substrate was polylactic acid-glycolic acid, the diameter of the microneedles, the length of the microneedles and the distance between the centers of the microneedles were 100 μm, 0.6 mm and 0.15 mm, respectively, and the pH of the microstructures was 7.5, other performance parameters are shown in Table 3.

[0034] 0.5 g of microstructured microneedles were put into 1 ml centrifuge tubes, and 200 μl of hyaluronidase and / or collagenase solution was added to each tube so that the concentration of the enzyme was 30 IU / ml. The sample without enzyme addition and other operations kept the same as the control. 37°C constant temperature for 16 hours. After the reaction, each tube was centrifuged, the supernatant was discarded, and the weight of the sample remaining at the bottom of the tube was determined. The weight meas...

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Abstract

The invention relates to a degradable microstructure body and a preparation method thereof. The degradable microstructure body is mainly composed of a microneedle and a base where the microneedle is erected. The preparation method includes the steps that firstly, gel used for preparing the base and the microneedle is provided, and an antalgic material is added into the gel of the microneedle; secondly, a mould is provided; thirdly, injection molding is carried out; fourthly, curing and sterilizing are carried out. The microstructure body has the advantages of being long-acting in sustained release, good in experience feeling, simple in process and the like, and can be applied to the fields of biological medicine and medical cosmetology.

Description

technical field [0001] The invention relates to a degradable microstructure and a preparation method thereof, in particular to a biodegradable microstructure inserted into human skin, which can be applied to the fields of biomedicine and medical cosmetology. Background technique [0002] At present, oral administration and injection are the most commonly used drug delivery methods in the field of biomedicine and medical cosmetology. However, the drug efficacy is not high after oral administration of gastric acid, and the injection needle will stimulate the nerve cells in the deep layer of the skin and easily cause pain to the human body. In recent years, some people have begun to study biodegradable microstructures added with functional ingredients as a solution to the above-mentioned shortcomings of the above-mentioned drug delivery in the fields of biomedicine and medical cosmetology. The biological microstructure penetrates into the skin to supply the functional ingredien...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/38A61K47/42A61K47/36A61K31/167A61K31/485A61P25/04A61P29/00
CPCA61K9/0097A61K9/0021A61K31/167A61K31/485A61K47/36A61K47/38A61K47/42
Inventor 李媚
Owner 李媚
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