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New application of FG-4592 or salt thereof as well as medicine product and health-care product

A FG-4592, 1. The technology of FG-4592 is applied in the field of medicine and health care products to achieve the effect of improving spatial memory function

Inactive Publication Date: 2018-08-28
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, so far, whether FG-4592 can improve cognitive dysfunction by activating the HIF signaling pathway has not been reported

Method used

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  • New application of FG-4592 or salt thereof as well as medicine product and health-care product
  • New application of FG-4592 or salt thereof as well as medicine product and health-care product
  • New application of FG-4592 or salt thereof as well as medicine product and health-care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Protective effect of FG-4592 on cognitive function in aged APP / PS1 transgenic mice

[0037] 1. Treatment of FG-4592 drug and mice

[0038] (1) Treatment of FG-4592 medicine: Dissolve 100mg of FG-4592 whole medicine in 22ml and 11ml of 5% (volume ratio) DMSO+50% (volume ratio) PEG300+ddH 2 O solution; fully dissolved and stored at -20°C. Among them, DMSO is dimethyl sulfoxide; PEG300 is polyethylene glycol 300; ddH 2 O refers to double distilled water, that is, water obtained after two distillations.

[0039] (2) Treatment of mice: the experimental mice were 6-month-old APP / PS1 transgenic mice, weighing 30±5 g, male. During the experiment, the animals were kept in a standardized animal breeding room with free access to food and water. According to the body weight of the mice, the FG-4592 solution prepared in step (1) was intraperitoneally injected into the mice once every other day, and the volume of each injection was 100 μl. When the total injection dose is 15 mg / ...

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PUM

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Abstract

The invention relates to new application of FG-4592 or salt thereof as well as a medicine product and a health-care product. The new application is the application of the FG-4592 or pharmaceutically acceptable salt thereof to preparation of products for treating and / or preventing nerve injury diseases or neurodegenerative diseases. The products can be medicine products and / or health-care products.The limitation that the existing FG-4592 is only used for treating anemia is overcome; and the FG-4592 can obviously improve the spatial memory function of APP / PS1 transgenic mice, can improve the condition that the cognitive function is reduced, and can be used for treating early cognitive impairment, stroke, Alzheimer disease, cognitive impairment, vascular dementia, Parkinson's disease and thelike.

Description

technical field [0001] The present invention relates to the technical field of medicine and health products, in particular to the new application of FG-4592 and medicines and health products, especially to the use of FG-4592 or a pharmaceutically acceptable salt thereof in the preparation of treatment and / or prevention of nerve injury diseases or neurodegeneration Use in disease products. Background technique [0002] Cognition is the process by which the brain receives external environmental information, processes it, converts it into internal mental activities, and then acquires knowledge or application skills, including memory, language, visual space, execution, calculation, understanding and judgment. Cognitive impairment refers to the impairment of one or more of the above cognitive functions and affects the daily life and social ability of the individual. Alzheimer's disease affects more than 1.5 million people worldwide and is the most common cause of cognitive impai...

Claims

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Application Information

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IPC IPC(8): A61K31/472A61P25/00A61P25/28A61P9/10A61P25/16C07D217/26A23L33/00
CPCA61K31/472A23L33/00A23V2002/00C07D217/26A23V2200/322
Inventor 朱玲玲周延召赵彤赵名范明吴海涛
Owner ACADEMY OF MILITARY MEDICAL SCI
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