New application of FG-4592 or salt thereof as well as medicine product and health-care product
A FG-4592, 1. The technology of FG-4592 is applied in the field of medicine and health care products to achieve the effect of improving spatial memory function
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[0035] Example 1
[0036] The protective effect of FG-4592 on the cognitive function of aged APP / PS1 transgenic mice
[0037] 1. FG-4592 drugs and treatment of mice
[0038] (1) Treatment of FG-4592 medicine: Dissolve 100mg of FG-4592 whole medicine in 22ml and 11ml of 5% (volume ratio) DMSO+50% (volume ratio) PEG300+ddH respectively 2 O solution; after fully dissolved, aliquot and store at -20°C. Among them, DMSO is dimethyl sulfoxide; PEG300 is polyethylene glycol 300; ddH 2 O refers to double distilled water, that is, water obtained through two distillations.
[0039] (2) Treatment of mice: The experimental mice were 6-month-old APP / PS1 transgenic mice, weighing 30±5g, male. During the experiment, the animals were kept in a standardized animal breeding room, and they could eat and drink freely. According to the weight of the mouse, the FG-4592 solution prepared in step (1) was injected into the intraperitoneal cavity of the mouse every other day, and the volume of each injection ...
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