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Sterile microstructure body and preparation method thereof

A technology of microstructures and microneedles, which is applied in the fields of biomedicine and medical cosmetology, can solve the problems of high manufacturing cost, inability to guarantee the hardness and use effect of microneedles, complicated process, etc., and achieve the effect of excellent hardness

Pending Publication Date: 2016-04-20
李媚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main material of the microneedle array of this patent is carbohydrates. Although it overcomes the risk of ordinary solid microneedle fragments remaining in the skin, it does not solve the problem of long-term sustained release and cannot be effectively controlled.
Application numbers CN201180067944.5 and CN201380025634.6 respectively provide microneedle manufacturing methods, but these manufacturing methods use a lot of materials, complex processes, cumbersome steps, high manufacturing costs, and cannot guarantee the hardness and use effect of microneedles
The patent application number CN201410684523.2 provides a sericin microneedle for drug delivery and its preparation method. Although sericin is a research hotspot this year, its related products are used in the field of biomedicine or medical beauty The mechanism is still immature, and the patent does not solve the problem of controlled release of microstructures

Method used

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  • Sterile microstructure body and preparation method thereof
  • Sterile microstructure body and preparation method thereof
  • Sterile microstructure body and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Performance comparison of microstructures

[0024] In this experiment, the performance of several microstructures was compared. The biodegradable material of the substrate and the microneedle column is both dextrin, and the pH of the microstructure is 7.1. Other performance parameters are shown in Table 1.

[0025] Hardness test method: Insert the tip of the microstructure into a rubber with a thickness of 2.5mm at an insertion speed of 6mm / s, and measure the maximum force when inserting the rubber, which is the hardness of the microstructure. The greater the insertion force, the higher the hardness.

[0026] Table 1.

[0027]

Embodiment 2

[0028] Embodiment 2: Performance comparison of microstructures

[0029] In this experiment, the properties of several microstructures were compared. The substrate was carboxymethyl cellulose, the water content of the needle column was 25.2% (W / W), and the pH of the microstructure was 7.2. Other performance parameters are shown in Table 2. The method of hardness test is the same as that of Example 1.

[0030] Table 2.

[0031]

Embodiment 3

[0032] Example 3: Performance comparison of microstructures containing additives

[0033] In this experiment, the properties of several microstructures were compared. The substrate is silk protein, the biodegradable material is polyacrylamide polymer, and the pH of the microstructure is 7.0. Other performance parameters are shown in Table 3. The method of hardness test is the same as that of Example 1.

[0034] table 3.

[0035]

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Abstract

The invention relates to a sterile microstructure body and a preparation method thereof. The microstructure body is mainly composed of micro-needle pillars and a substrate on which the micro-needle pillars stand; and the preparation method comprises the following steps: 1) preparing the substrate; 2) dropping gels on the substrate; 3) drawing the gels which are dropped, so that the micro-needle pillars are formed; and 4) sterilizing. The microstructure body provided by the invention has the advantages of excellent hardness, controllable degradation, sustained release, simple preparation and the like; and the microstructure body is applicable to the fields of biomedicine and medical cosmetic.

Description

technical field [0001] The invention relates to a sterile microstructure and a preparation method thereof, in particular to a biodegradable microstructure inserted into human skin, which can be applied to the fields of biomedicine and medical cosmetology. Background technique [0002] In the field of biomedicine and medical cosmetology, in addition to the most commonly used methods of oral administration and injection, people have also studied the way of transdermal administration to overcome the inefficiency of the drug after oral administration through gastric acid and the irritation of injection needles. Nerve cells in the deep layer of the skin are prone to causing pain and other defects to the human body. In biomedicine, transdermal drug delivery requires the use of drug penetration into the skin for drug delivery, but due to the barrier effect of the outer layer of the skin on drug absorption, the drug absorption rate is very low, and many macromolecular drugs cannot b...

Claims

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Application Information

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IPC IPC(8): A61M37/00
Inventor 李媚
Owner 李媚
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