33results about How to "Freeze-drying time is short" patented technology

The invention belongs to the technical field of medicines, and relates to a fludarabine phosphate freeze-dried powder injection and a preparation method thereof. The fludarabine phosphate freeze-dried powder injection consists of fludarabine phosphate and mannitol in a mass ratio of 1:(0.6-1.2). The method for preparing the fludarabine phosphate freeze-dried powder injection comprises the following steps of: adding water for injection into a liquid preparing tank, adding the fludarabine phosphate in a prescription amount, adding alkali, stirring until the mixture is dissolved completely; and adding the mannitol, regulating the pH value, adding active carbon for decolorizing, filtering for decolorizing, performing fine filtering by using a filter membrane, subpackaging, and performing freeze drying. The fludarabine phosphate freeze-dried powder injection has excellent formability, clarified appearance of solution to be frozen, high redissolution performance of freeze-dried products, high clarity after redissolution, low impurity content and moisture content, high stability and controllable quality.

The invention discloses a multi-vitamin parenteral nutrition nanosphere freeze-dried injection, which is composed of 13 kinds of vitamins, medium-chain triglycerides, soybean lecithin, 15-hydroxystearic acid polyethylene glycol ester, glycerin , mannitol and water, wherein the mass ratio of soybean lecithin to polyethylene glycol 15-hydroxystearate is 1: (1.4-4); medium-chain triglycerides, soybean lecithin and 15-hydroxystearate The mass ratio of the total weight of polyethylene glycol stearate is 1: (1-4). In the present invention, fat-soluble vitamins are made into a lipid nanosphere solution, which can be co-dissolved with water-soluble vitamin solutions, and the problem of co-dissolution of fat-soluble vitamins and water-soluble vitamins is solved in an ingenious way. The multivitamin parenteral nutrition nanosphere freeze-dried finished product of the present invention is a clear and transparent liquid after reconstitution with water, and can be diluted with infinite aqueous solution. The product of the present invention has high safety, high quality, good stability, and easy operation of the production process. , low production cost.

The invention relates to a vidarabine monophosphate freeze-dried powder injection and a preparation method thereof, and the vidarabine monophosphate freeze-dried powder injection is prepared by freeze-drying vidarabine monophosphate, sodium hydroxide solution and water for injection, wherein the sodium hydroxide solution is used as a pH regulator, and the sodium hydroxide solution is used until the pH value of liquid medicine is 7.0-7.5. The vidarabine monophosphate freeze-dried powder injection provided by the invention is few in types of auxiliary materials, low in using amount, good in forming property of a freeze-dried product, good in re-dissolving property, clear in appearance of the solution before freezing, good in clarity after being freeze-dried, low in content of impurities, good in stability and controllable in quality, and can reduce the potential safety hazard of the vidarabine monophosphate freeze-dried powder injection, and improve the efficacy of the vidarabine monophosphate freeze-dried powder injection.

The invention relates to lafutidine freeze-dried injection, which can treat gastric ulcer, duodenal ulcer and ulcer on the anastomosed part. The lafutidine freeze-dried injection is composed of lafutidine and mannitol, wherein, the mass ratio of the lafutidine and the mannitol is 1 : 10 to 100; the preferable mass ratio is 1 : 20 to 50; and one or the mixture of sodium chloride and citrate can be added into the lafutidine freeze-dried injection so as to prevent the medicine bottle from exploding in the process of freeze-drying the lafutidine freeze-dried injection. The preparation processes are as following: the lafutidine is taken to be placed inside the aseptic container, and then the water for injection is added to be heated until the temperature reaches 70 DEG C so that the lafutidine can be dissolved in the water for injection; and then the mannitol is added to be mixed so that the mannitol can be dissolved and is mixed evenly; the content of the intermediate is measured; after the content of the intermediate is qualified, in the aseptic condition, the solution is filtered until to be clear by microporous membrane of 0.22 microns; the filtrate is filled inside the aseptic silin bottle; and part of the silin bottle is plugged by butyl rubber closure, with the posterior steps of tray filling, freeze-drying in the freeze dryer, tamponing, unpacking, mouth rolling, quality inspecting and packaging.

The invention provides a porcine pseudorabies live vaccine freeze-drying heat-resisting protective agent, a preparation method and an application thereof. The protecting agent is characterized by being free of gelatin and proteins. The protecting agent contains the following components in percentage by weight: 2-8% of saccharose, 3-6% of isomaltulose, 1-5% of D-sorbitol, 1-5% of glycerinum, 0.1-5%of hydroxypropyl methylcellulose, 0.1-3.5% of methionine, 0.01-0.05% of poly-D-lysine, Hanks (containing phenol red) and the balance of double pure water, totaling 100%. The porcine pseudorabies livevaccine prepared by the freeze-drying heat-resisting protective agent is relatively good in heat resistance, the freeze-drying loss is 0.5-0.65Lg, the heat resistant loss at 37 DEG C for 10 days is 0.2-0.25Lg, and the storage life loss at 2-8 DEG C for 30 days is 0.7-0.9Lg. The low-temperature cold chain problem in storage and transportation of the vaccine is solved, and in particular the rural low-temperature cold chain problem in a remote region is solved.

The invention relates to a chymotrypsin preparation, particularly relates to chymotrypsin composition freeze-dried powder and a preparation method thereof. The hymotrypsin composition freeze-dried powder comprises chymotrypsin, dextran 20 and sorbitol, wherein the ratio of chymotrypsin to dextran 20 to sorbitol is 1 million units: 1-1.8g: 0.05-0.6g. The average porosity of the hymotrypsin composition freeze-dried powder is 85-98%. The invention further relates to a preparation method of the hymotrypsin composition freeze-dried powder. The hymotrypsin composition freeze-dried powder disclosed herein has the advantages of full and uniform appearance, high porosity, good re-solubility, high stability, simple prescription, low proportion of pharmaceutic adjuvants, low side effect to human body, safety and reliability. According to the invention, the preparation technology of the hymotrypsin composition freeze-dried powder is further improved, the temperature, liquid volume, and freeze-drying process are improved, and sterilization is conducted twice.

The invention relates to the field of pharmaceutic preparations and discloses a method for preparing gemcitabine hydrochloride lyophilized powder. According to the method for preparing the gemcitabine hydrochloride lyophilized powder, a primary pre-freezing process and a stage drying process are used for lyophilization; appropriate vacuum degrees and temperature are matched at all drying stages to avoid the problem that hydrochloric acid is removed from gemcitabine hydrochloride under high vacuum degree, and drying efficiency is low due to low vacuum degree; meanwhile, temperature is slowly raised at different speed at different drying stages, and the problem that the gemcitabine hydrochloride is deacidified due to too high heating speed can be solved. Compared with the prior art, the method for preparing the gemcitabine hydrochloride lyophilized powder has the advantages that the method is easy to operate, lyophilization time is short, and drying temperature is low; the prepared gemcitabine hydrochloride lyophilized powder product is high in outer structural quality and redissolution performance; a redissolution solution is clear and transparent, and opalescence is avoided; relative substances are low in content, and the prepared gemcitabine hydrochloride lyophilized powder is safe and reliable in quality; and the method is suitable for preparing the gemcitabine hydrochloridelyophilized powder and can be widely applied to large-scale production of the gemcitabine hydrochloride lyophilized powder.

The present invention relates to a Clofarabine freeze drying powder and the preparation method, which comprises Clofarabine and at least one biological acceptable excipient. Wight ratio of the Clofarabine and the excipient is from one to 10 till one to 50. The excipient is selected from one kind of mannitol and lactose. The optional choice is the mannitol. The preparation method is as following. The Clofarabine is melted with the injection water and the excipient is added. Followed by well mixing , filtration, packaging, adding stopper and loading in the plate. The freeze dryer is opened in advance. The platelayer is cooled with the heat conduction oil until temperature of the platelayer increases till minus 40 DEG Cto minus 50 DEG C. The Clofarabine solution packaged in the sterile silinbottle can be sent to the freeze dryer quickly.The box door is shut and the plate temperature is kept at minus 40 DEG Cto minus 50 DEG C and the box temperature is decreased. When the sample temperature reaches minus 40 DEG C, The plate cooling is stopped and the condenser is opened. At the same time the product temperature is maintaineed by cooling for 3 hours. When the temperature of the condenser reaches minus 40 DEG, the vacuum system is opened. After temperature holding, four steps of heating, sublimation, drying, plugging, box pressing and opening sealing can be started.