A method capable of increasing the acre yield of momordica grosvenori includes the following steps of 1, preparation before planting and planting, wherein momordica grosvenori seedlings and planting land are selected, land preparation and insect killing are carried out, a shed is built with high piles and low piles arranged alternately in rows, and the seedlings are planted; 2, seedling-stage management, wherein after seedling emergence of plants, bagging is carried out, seedling growth promoting fertilizer is applied, soil is kept moist, and the seedlings are bound to climb to the shed; 3, growing-stage management, wherein bud picking and vine sorting are carried out, and topping and vine sorting are carried out; after the plants climb to the shed, soil is kept moist, flowering promoting fertilizer and water fertilizer are applied, and viral diseases are prevented and treated; 4, breeding-stage management, wherein after male plants and female plants flower, artificial pollination is carried out, soil is kept moist, and seed strengthening fertilizer is applied; 5, fruit strengthening and harvesting, wherein half a month after pollination, fruit strengthening fertilizer is applied, and after fruits are ripe, harvesting is carried out. By means of the method, the planting cost and land cost are reduced on the premise that the acre yield is higher than an existing acre yield, so that the profit of momordica grosvenori is maximized, wherein the profit can be increased by 3025 yuan compared with that in an existing planting technology; operation is simple and clear, and the practicability is high.