20 results about "Phenylmethylamine" patented technology

The invention relates to a preparation method of phenylmethylamine. The technical scheme adopted by the invention for mainly solving the problems of high catalyst loss, low production efficiency and high intermittent operation labor intensity is as follows: the preparation method of the phenylmethylamine comprises the following steps: mixing the raw material of cyanobenzene with a solvent material or at least one of one part of product materials in a mixing unit, introducing the mixture into a fixed bed hydrogenation reactor to be in contact with hydrogen and a catalyst and carry out multi-phase continuous hydrogenation reaction to obtain a product material containing phenylmethylamine, separating the product material to obtain a phenylmethylamine product, wherein the catalyst is a metal loaded catalyst; and the metal is selected from at least one of Pd, Pt, Cu, Ni, Mo and Fe. The preparation method can be used for preparing phenylmethylamine.

A method for preparing a labeling agent includes: providing a compound including a chelating moiety and a conjugation moiety; contacting the compound with a radionuclide to create a radiolabeled preparation having a first molar activity; and purifying the radiolabeled preparation to prepare a labeling agent having a second molar activity that is greater than the first molar activity. A biological material can be contacted with a labeling agent prepared by the method such that the biological material becomes labeled for imaging. In one example embodiment, there is provided a way of synthesizing a labeling agent, such as 89Zr-labeled p-isothiocyana to-benzyl-desferrioxamine, using a purification step that results in increased molar activity and labeling efficiency, which makes possible the successful labeling of biological materials at very low concentrations where an unpurified labeling agent would be unsuccessful.

The application relates to the technical field of peptide synthesis, and discloses a preparation method of a snake venom-like tripeptide, which comprises the following steps: condensing Boc-beta-Ala-OH and H-Pro-OMe, hydrolyzing the methyl ester groups to obtain Boc-beta-Ala-Pro-OH; condensing Boc-Gln-OH and benzylamine, and removing Boc to obtain H-Gln-NHBzl; then condensing Boc-beta-Ala-Pro-OH and H-Gln-NHBzl to prepare a polypeptide; and after the Gln in the polypeptide is subjected to Hofmann rearrangement, the Boc protection group in the polypeptide is removed to obtain the snake venom-like tripeptide. The preparation method adopts liquid-phase synthesis of the snake venom-like tripeptide, the synthesis route is short, the reaction condition is mild, special equipment and reagents are not needed, the operation steps are simplified, the process cost is reduced; the reaction reagents used are cheap and easy-to-obtain industrial reagents, the raw material cost is reduced; and the product purity can reach more than 99%.

The invention discloses a modified bismuth oxybromide composite photocatalyst as well as a preparation method and application thereof, and belongs to the technical field of photocatalytic organic synthesis. The preparation method comprises the following steps: mixing Bi (NO3) 3, KBr and Cu (NO3) 2, adding chlorophyll, and stirring to obtain the modified bismuth oxybromide composite photocatalyst. The Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is synthesized, the Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is used for photocatalysis of bimolecular oxidative coupling of benzylamine and methylamphetamine, bimolecular coupling of methylamphetamine and benzylamine is carried out under 10W visible light for the first time, the conversion rate can reach 99.5%, the product is alpha-methyl-N-(benzylidene) phenylethylamine, and the product has a wide application prospect. The method realizes detoxification treatment of methylamphetamine, realizes efficient and green synthesis of an imine compound under a noble metal-free condition, and can efficiently photocatalyze oxidative coupling of methylamphetamine and chemically degrade pollutants in water.

The present invention belongs to the field of photocatalytic oxidation technology, and specifically relates to a method for preparing an asymmetric Schiff base containing an aromatic group by efficiently photocatalytically oxidizing a benzylamine derivative. The method comprises the following steps: using naphthalene imide flavin or riboflavin tetraacetate as a photosensitizer, dissolving the photosensitizer and two different benzylamine derivatives in an organic solvent, and conducting a light-irradiation reaction at room temperature, pressure, and air to obtain an asymmetric Schiff base containing an aromatic group. The method prepares an asymmetric Schiff base containing an aromatic group at room temperature and pressure, has low energy consumption, is simple and easy to operate, and can be used for large-scale production. No heavy metals are used in the preparation process, making it environmentally friendly and low-cost.

The invention relates to a BDPMA compound, a preparation method thereof and application of the BDPMA compound in assisting homogeneous synthesis of KLC tripeptide amide, and belongs to the technical field of organic synthesis. The BDPMA compound provided by the invention is a 4, 4 '-diphenylphosphonooxy diphenylmethylamine compound, and the structural formula of the BDPMA compound is shown in the description. The invention mainly solves the problems that the Fmoc-KLC tripeptide amide chemical synthesis method has many liquid phase reaction steps, long time-consuming period, high content of by-product beta-type isomeride, difficulty in separation and impurity removal, low product purity, large purification scale and high production cost, and the solid phase reaction has small generation scale, high raw material price, large waste and low production cost. The problems of more resin wastes and serious environmental pollution are solved.

A substance, in particular a functionalized oligomer or polymer, wherein the substance contains oligomeric or polymeric chains to which perfluoroaromatic compounds are coupled or which contain perfluoroaromatic compounds, wherein several, in particular two, three, four or five fluorine atoms of the perfluoroaromatic compound are each nucleophilically substituted by a functional group, characterized in that a functional group is coupled to the perfluoroaromatic compound such that a fluorine atom is substituted by a sulfur atom, wherein the functional group comprises a linear and / or branched saturated or unsaturated C n -body, especially a C2, C3, C6, C8, C 10 -, C 12 -, C 14 -, C 16 - or a C 18 -body having at one end the sulfur atom which substitutes a fluorine atom of the perfluoroaromatic compound, wherein at the other end of the Cn - body a quinuclidinium group or another quaternary N-group, in particular an ammonium, imidazolium, benzimidazolium, piperidinium, piperazinium, guanidinium, pyridinium group, preferably with counterions, in particular with a bis(trifluoromethylsulfonyl)amide anion or a mineral acid anion, in particular a halide (F - , Cl - , Br - , I - ) or SO4 2- , HSO 4- , PO4 3- , HPO4 2- , H2PO 4- , SO3 2- , SO3H - , Phosphonate R-PO3H - , Carbonate CO3 2- , HCO 3- , or with an organic carboxylic acid anion, in particular CH3COO - , HCOO - , is coupled, and / or that a functional group SO3 is coupled to a countercation, in particular to a metal countercation or an ammonium countercation in the form NR4 +containing R = H, alkyl, aryl or another N-basic cation, in particular imidazolium, benzimidazolium, guanidinium, which is coupled to a sulfur atom substituting a fluorine atom, and / or containing a functional group C5NH 10 containing, wherein the nitrogen atom substitutes the fluorine atom of the perfluoroaromatic compound, wherein in particular a residue is coupled via the nitrogen atom, wherein the residue preferably is a halide (F - , Cl - , Br - , I - ) or SO4 2- , HSO 4- , PO4 3- , HPO4 2 , H2PO 4- , SO3 2- , SO3H - , Phosphonate R-PO3H - , Carbonate CO3 2- , HCO 3- or an organic carboxylic acid anion, in particular CH3COO - , HCOO - , is.

The invention relates to the technical field of molecular fluorescence, in particular to a polarity-sensitive fluorescent probe based on ICT and a preparation method and application of the polarity-sensitive fluorescent probe. The preparation method of the polarity sensitive type fluorescent probe comprises the following steps: enabling 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine, and enabling the 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine. The preparation method comprises the following steps: enabling 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine and (6-nitropyridine-3-yl) boric acid to react, so as to prepare the polarity sensitive type fluorescent probe. The polarity-sensitive fluorescent probe can be used as an effective tool for detecting the polarity change of the lipid droplet, and provides auxiliary diagnosis for diagnosis of some diseases related to the lipid droplet by dynamically monitoring the continuous process of the lipid droplet from generation to maturation to decomposition.

The application discloses a zirconium-based porous metal organic framework catalyst, a preparation method and application. The catalyst is an MOF808 catalyst prepared from Zr salt and 1,3,5-benzene tricarboxylic acid in a molar ratio of 1:1. The catalyst, benzoic acid, benzylamine and a reaction solvent are placed in a reaction container, and an amine acid condensation reaction is carried out under nitrogen protection to obtain N-benzyl benzamide. The reaction temperature of the amine acid condensation reaction is 40-120 DEG C, and the reaction time is 2-24 h. The catalyst can efficiently and selectively condense benzoic acid and benzylamine to prepare N-benzyl benzamide under the condition that the reaction temperature is 90 DEG C and the solvent is tetrahydrofuran, and has the advantages of high conversion efficiency, good product selectivity, mild reaction condition, easy recycling and the like.

The invention belongs to the technical field of photocatalysis, and particularly discloses supramolecular hydrogel with the aggregation-induced emission characteristic, a preparation method of the supramolecular hydrogel and application of the supramolecular hydrogel to photocatalysis, the structural formula of amphiphilic guest molecules is as shown in the formula (1): # imgabs0 #, n is 2-10, and the number m of carbon atoms of alkyl chains is 6-18. The supramolecular hydrogel with the aggregation-induced emission characteristic is prepared from a host-guest compound formed by the amphiphilic guest molecule and water-soluble pillararene as well as a photoinitiator and an acceptor molecule of the host-guest compound. And catalyzing a dehalogenation reaction and / or an oxidative coupling reaction of benzylamine.

The invention discloses a synthesis method of 1-benzyl-4-[3-(benzyloxy) propyl]-1, 3-dihydro-2H-pyrrole-2-ketone, and belongs to the technical field of organic synthesis. The invention discloses a preparation method of 1-benzyl-4-[3-(benzyloxy) propyl]-1, 3-dihydro-2H-pyrrole-2-ketone, which comprises the following steps: in a reactor, in an inert atmosphere, reacting a 6-(benzyloxy)-3-formyl tert-butyl hexanoate compound with benzylamine under the catalysis of glacial acetic acid, and after the reaction is finished, carrying out subsequent separation and purification to obtain the 1-benzyl-4-[3-(benzyloxy) propyl]-1, 3-dihydro-2H-pyrrole-2-ketone. The method provided by the invention has the advantages of simple steps, safe operation, non-toxic and easily available raw materials, simple and easy process and small pollution, and accords with the idea of green chemistry.

The invention discloses a medical examination fluorescent molecular probe and a preparation method thereof in the technical field of medical examination, and the medical examination fluorescent molecular probe is prepared from the following components in parts by weight: 17 to 19 parts of 3, 4-difluorobenzaldehyde, 12 to 15 parts of benzylamine, 10 to 11 parts of piperidine, 24 to 26 parts of 1, 4-dimethyl pyridine iodide, 14 to 15 parts of 1-isopropyl pyrimidine-2, 4, 6 (1H, 3H, 5H)-triketone and 6.2 to 7.1 parts of potassium fluoborate. According to the present invention, the 3, 4-difluorobenzaldehyde is modified with benzylamine, such that the steric hindrance is improved so as to achieve the technical effect of selectivity improvement, and the 1-isopropylpyrimidine-2, 4, 6 (1H, 3H, 5H)-triketone is modified to synthesize the flavin compound so as to obtain the high-sensitivity anti-interference fluorescent molecular probe.

The application discloses a nirmatrelvir intermediate and a preparation method and application thereof, and belongs to the technical field of drug synthesis. The nirmatrelvir intermediate and the preparation method thereof are characterized in that 3-methyl-2-butenal is used as a starting material, and a first reactant is obtained through reductive amination reaction of the 3-methyl-2-butenal and benzylamine; acylation reaction of the first reactant and bromoacetyl bromide is performed to obtain a second reactant; under the condition that tetramethylguanidine is used as an alkali, diazotization reaction of the second reactant and N,N'-bis(p-tolylsulfonyl)hydrazine is performed to obtain a diazo compound; and the diazo compound is catalyzed by a metal catalyst to obtain a chiral pure cyclopropane compound, namely the nirmatrelvir intermediate. The method for preparing the nirmatrelvir intermediate has the advantages that a metal catalyst is used for catalysis, the reaction condition is mild, and the ee value of the obtained target product can reach 92.6%.

The present invention relates to the use of at least one antioxidant in a lubricating composition, wherein the at least one antioxidant comprises at least one oligomer and / or polymer comprising at least one diphenylamine repeating unit, for reducing and / or preventing the toxicity of the lubricating composition.

A method of making benzalaniline, the method comprising: providing benzaldehyde and aniline; performing a condensation reaction using a solvent; extracting water from the condensation reaction using a pervaporation system, wherein a poly(vinyl alcohol) PVA membrane is in the pervaporation system; and obtaining benzalaniline.

A diphenylphosphonoxybenzhydrylamine tag-assisted liquid-phase eptifibatide total synthesis method utilizes a diphenylphosphonoxybenzhydrylamine tag instead of a solid-phase peptide synthesis polymer resin as a peptide synthesis carrier and amino acid carboxyl-terminal protecting group for eptifibatide total synthesis. The method includes amide coupling of the Fmoc-protected diphenylphosphonoxybenzhydrylamine tag with an amino acid, preparation of an eptifibatide peptide chain assisted by the diphenylphosphonoxybenzhydrylamine tag, cleavage and removal of the diphenylphosphonoxybenzhydrylamine tag and side chain protecting groups, and oxidative cyclization of linear eptifibatide to prepare eptifibatide. The diphenylphosphonoxybenzhydrylamine tag in the present invention has good solubility in the reaction medium and assists in peptide chain precipitation and purification, thereby achieving a simple, efficient, green and economical synthesis of eptifibatide.

The invention belongs to the technical field of photocatalytic materials, and provides a Bi / Bi2MoO6 photocatalytic material as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing an ethylene glycol solution of Bi (NO3) 3.5 H2O, an ethylene glycol solution of Na2MoO4. 2H2O and ethanol, and then carrying out hydrothermal reaction to obtain the Bi / Bi2MoO6 photocatalytic material. The photocatalytic material prepared by the invention has efficient photocatalytic oxidation and coupling of diphenyl methylamine, when ethyl acetate is used as a reaction solvent, the conversion rate of a 10W LED lamp to benzene methylamine is up to 99.67% after 365-370nm ultraviolet light irradiation for 3h, and meanwhile, the selectivity to a target product N-benzylidenebutylamine is up to 96.74%.

Provided are a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided are a pharmaceutically acceptable salt, isomer, racemate, prodrug co-crystal complex, hydrate, and solvate of the compound, as well as an application thereof in the preparation of a drug for the treatment or prevention of RORγ-regulated diseases; more importantly, such a compound can also be used in the preparation of a drug for the treatment of inflammation, immune diseases, cancer and neurological diseases.

The invention provides a preparation method and application of an ultrathin vanadate nanobelt with in-plane microcell heterogeneity, a hydrothermal synthesis method is utilized, Na3VO4 or NH4VO3 and metal chlorides with different molar ratios are used as precursors, different vanadates exist on the same nanobelt, and microcell heterogeneity regulation on the same nanobelt is realized. The method is simple, has general applicability, and has wide application prospects in the aspects of photocatalytic carbon dioxide reduction, benzyl alcohol oxidation, benzylamine coupling and the like.